Imidazothiazole-chalcone-cpd6
IC50 AChE 751.62 +/- 0.94 pM; IC50 BChE 73.51 +/- 0.06 pM; Ki AChE 371.04 +/- 41.12 pM; Ki BChE 43.52 +/- 4.77 pM
General
Type : Chalcone, Thiazole, Sulfur Compound, Imidazol
Chemical_Nomenclature : (E)-1-(4-Chlorophenyl)-3-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)prop-2-en-1-one
Canonical SMILES : C12=NC(=C([N]1C=CS2)C=CC(C3=CC=C(C=C3)Cl)=O)C4=CC=C(C=C4)F
InChI : InChI=1S\/C20H12ClFN2OS\/c21-15-5-1-13(2-6-15)18(25)10-9-17-19(14-3-7-16(22)8-4-14)23-20-24(17)11-12-26-20\/h1-12H
InChIKey : DIEIDACEUCTPCI-UHFFFAOYSA-N
Other name(s) : Compound 6
Target
Families : Imidazothiazole-chalcone-cpd6 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Synthesis, characterization and biological evaluation of novel imidazothiazole-based chalcone derivatives as cholinesterase inhibitors through computational and experimental approaches - Ozcan_2026_Bioorg.Chem_182_110540 |
| Author(s) : Ozcan I , Erdogan T , Taslimi P , Sadeghian N , Tahtaci H |
| Ref : Bioorg Chem , 182 :110540 , 2026 |
| Abstract : |
| PubMedSearch : Ozcan_2026_Bioorg.Chem_182_110540 |
| PubMedID: 42759392 |