Isatin-1,3,5-triazine-benzylamine
C50 values of 0.86 nM and 660 nM against AChE and BChE, respectively, inhibit self and Cu2+-induced A140 peptide aggregations
General
Type : Multitarget, Triazine, anti-Abeta-aggregation, Indole, Isatin
Chemical_Nomenclature : 1-Benzyl-3-(2-(4-(benzylamino)6methoxy-1,3,5-triazin-2-yl)hydrazono)indolin-2-one
Canonical SMILES : N1=C(N=C(N=C1OC)NCC2=CC=CC=C2)NN=C3C(N(C4=C3C=CC=C4)CC5=CC=CC=C5)=O
InChI : InChI=1S\/C26H23N7O2\/c1-35-26-29-24(27-16-18-10-4-2-5-11-18)28-25(30-26)32-31-22-20-14-8-9-15-21(20)33(23(22)34)17-19-12-6-3-7-13-19\/h2-15H,16-17H2,1H3,(H2,27,28,29,30,32)
InChIKey : OMEPPSCTHRPWKK-UHFFFAOYSA-N
Other name(s) : Compound 6c
Target
Families : Isatin-1,3,5-triazine-benzylamine ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Evaluation of isatin-1,3,5-triazine-benzylamine hybrids as multi-target directed ligands against Alzheimer's disease - Tamaddon-Abibigloo_2025_J.Mol.Struct_1324_140717 |
| Author(s) : Tamaddon-Abibigloo Y , Dastmalchi S , Razzaghi-Asl N , Tuylu Kucukkilinc T , Shahbazi Mojarrad J |
| Ref : J Mol Struct , 1324 :140717 , 2025 |
| Abstract : |
| PubMedSearch : Tamaddon-Abibigloo_2025_J.Mol.Struct_1324_140717 |
| PubMedID: |