anti-Abeta-aggregation

General

The main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A\/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. Acetylcholinesterase is also thought to promote the aggregation. The peripheral anionic site on the surface participate in this process
Inhibitor Main targeted enzyme familyes Type Structure
AP2238 Multitarget Coumarin anti-Abeta-aggregation Chromen
Coumarin-phosphazide-Cpd8b Multitarget Coumarin anti-Abeta-aggregation Chromen
CHEMBL5206601 ACHE anti-Abeta-aggregation Multitarget Pyridine
Genistein-O-alkylbenzylamine-25d ACHE Multitarget Monoamine-oxidase-inhibitor anti-Abeta-aggregation Chromen
tacrine-isatin-Cpd7k ACHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
tacrine-isatin-Cpd7d BCHE anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol ACHE anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
Compound19n-quinolinol ACHE Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
Donepezil-idebenone-cpd9 BCHE Multitarget Antioxidant anti-Abeta-aggregation Derivative of Donepezil
Phenothiazine-Tacrine-1dC ACHE Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound
Tacrine-dipicolylamine-13a ACHE Derivative of Tacrine Alkyl linked bis-ligand Multitarget anti-Abeta-aggregation
Tetracyclic-triterpene-36e ACHE Terpenoid Natural_modified anti-Abeta-aggregation Sulfur Compound
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd35-Rivastigmine-5-HT6 BCHE Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
MTDL-cpd51-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
BIGI-3h ACHE BCHE Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil
Chlorotacrine-tryptophan-hybrid ACHE BCHE Derivative of Tacrine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand
Quinolinetrione-tacrine-Cpd3 ACHE Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone ACHE Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen