anti-Abeta-aggregation

General

The main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. Acetylcholinesterase is also thought to promote the aggregation. The peripheral anionic site on the surface participate in this process

Inhibitor	Main targeted enzyme families	Type
SCHEMBL24050818		Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
Diarylurea-hydroxyamidine-3q	BCHE	Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Diarylurea-hydroxyamidine-6e	BCHE	Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Ferulic-Acid-Piperazine-Cpd13a	ACHE	Multitarget Piperazin Quinoline Feruloyl Metal ion chelator anti-Abeta-aggregation
RIV-IND-5b2		Monoamine-oxidase-inhibitor Multitarget Derivative of Rivastigmine Indole anti-Abeta-aggregation
TAC-BIM-11d		Derivative of Tacrine Acridine Benzimidazole Carboxamide Multitarget anti-Abeta-aggregation
CHDA	ACHE	Derivative of Tacrine Acridine Azepane anti-Abeta-aggregation
AChE-HDAC-IN-1	ACHE BCHE	Multitarget HDAC inhibitor Derivative of Tacrine anti-Abeta-aggregation
HDAC6-IN-5	ACHE	Multitarget HDAC inhibitor Derivative of Tacrine anti-Abeta-aggregation
AP2238	ACHE	Multitarget Coumarin anti-Abeta-aggregation Chromen
Coumarin-phosphazide-Cpd8b	ACHE BCHE	Multitarget Coumarin anti-Abeta-aggregation Chromen
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d	BCHE	Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand anti-Abeta-aggregation
Amiridine-thiouracil-13c	BCHE	Quinoline Derivative of Tacrine Derivative of Amiridine Pyrimidine Sulfur Compound anti-Abeta-aggregation
CHEMBL5206601	ACHE	anti-Abeta-aggregation Multitarget Pyridine
Genistein-O-alkylbenzylamine-25d	ACHE	Multitarget Monoamine-oxidase-inhibitor anti-Abeta-aggregation Chromen
1d-phosphoryl-dihydroacridine	BCHE ACHE	Acridine Derivative of Tacrine Antioxidant anti-Abeta-aggregation
tacrine-isatin-Cpd7k	ACHE	anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
tacrine-isatin-Cpd7d	BCHE	anti-Abeta-aggregation Derivative of Tacrine Multitarget Alkyl linked bis-ligand Indole
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol	ACHE	anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide
Compound19n-quinolinol	ACHE	Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
Donepezil-idebenone-cpd9	BCHE	Multitarget Antioxidant anti-Abeta-aggregation Derivative of Donepezil
Phenothiazine-Tacrine-1dC	ACHE	Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound
Tacrine-dipicolylamine-13a	ACHE	Derivative of Tacrine Alkyl linked bis-ligand Multitarget anti-Abeta-aggregation
Tetracyclic-triterpene-36e	ACHE	Terpenoid Natural_modified anti-Abeta-aggregation Sulfur Compound
Cpd17-Tacrine-5-HT6	ACHE BCHE	Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd35-Rivastigmine-5-HT6	BCHE	Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
MTDL-cpd51-diphenylacetamide	BCHE	Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide	BCHE	Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10	BCHE	Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
SCHEMBL24135488	ACHE BCHE	Multitarget Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil Histamine-Receptor3-H3-Antagonist
BIGI-3h	ACHE BCHE	Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil
Chlorotacrine-tryptophan-hybrid	ACHE BCHE	Derivative of Tacrine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand
Quinolinetrione-tacrine-Cpd3	ACHE	Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone	ACHE	Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen
SB-1436	BCHE ACHE	Pyridine Naphthalen Pyridinium anti-Abeta-aggregation