anti-Abeta-aggregation

General

The main neuropathological feature of Alzheimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. Acetylcholinesterase is also thought to promote the aggregation. The peripheral anionic site on the surface participate in this process

Inhibitor	Main targeted enzyme families	Type
Chromene-Phenylpiperazine-Chalcone-Cpd9s	BCHE	Chalcone Monoamine-oxidase-inhibitor Piperazine Multitarget Chromen anti-Abeta-aggregation Coumarin
CHEMBL3322231-cpd5d	ACHE	Naphthyridine Derivative of Tacrine Acridine Multitarget Carboxamide Alkyl linked bis-ligand anti-Abeta-aggregation
CHEMBL3322231-cpd5d-derivCpd16	ACHE BCHE	Naphthyridine Derivative of Tacrine Acridine Multitarget Carboxamide Alkyl linked bis-ligand anti-Abeta-aggregation
CHEMBL3322231-cpd5d-derivCpd34	ACHE	Naphthyridine Derivative of Tacrine Acridine Multitarget Carboxamide Alkyl linked bis-ligand anti-Abeta-aggregation
CHEMBL3322232-cpd5a	ACHE BCHE	Naphthyridine Derivative of Tacrine Acridine Multitarget Carboxamide Alkyl linked bis-ligand anti-Abeta-aggregation
CHEMBL3322233	ACHE	Naphthyridine Derivative of Tacrine Acridine Multitarget Carboxamide Alkyl linked bis-ligand anti-Abeta-aggregation
CHEMBL3322231	ACHE BCHE	Naphthyridine Derivative of Tacrine Acridine Multitarget Carboxamide Alkyl linked bis-ligand anti-Abeta-aggregation
Chromen-oxybutanoyloxyethyl-triazol-ethyl-tacrine-Cpd17d	ACHE BCHE	Monoamine-oxidase-inhibitor Multitarget Chromen anti-Abeta-aggregation Derivative of Tacrine Acridine Coumarin Triazol
Fluoro-methylpiperazin-phenyl-oxo-chromene-carboxamide-CpdE12	ACHE	Monoamine-oxidase-inhibitor Multitarget Piperazine Carboxamide Chromen Coumarin anti-Abeta-aggregation anti-tau-aggregation
N-saccharinopentyl-benzylamino-cpd8b	ACHE	Alkyl linked bis-ligand Sulfur Compound Thiazole Benzothiazol Derivative of Saccharin Multitarget anti-Abeta-aggregation
Benzylpiperidin-dimethylamino-hydroxyphenyl-pyridazin-one-Cpd7a	ACHE	Pyridazine Piperidine anti-Abeta-aggregation Multitarget Benzylpiperidine Derivative of Donepezil
CHEMBL5176418	BCHE ACHE	Pyridazine anti-Abeta-aggregation Multitarget Alkyl linked bis-ligand
Amiridine-pyridoximine-cpd3c	ACHE BCHE	Derivative of Amiridine Quinoline Pyridine Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget
Amiridine-pyridoxamine-cpd4c	ACHE BCHE	Derivative of Amiridine Quinoline Pyridine Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget
Methoxytacripyrine	ACHE	Naphthyridine Calcium Channel Antagonist Derivative of Tacrine Multitarget anti-Abeta-aggregation
SCR-1693	ACHE	Naphthyridine Calcium Channel Antagonist Derivative of Tacrine Multitarget anti-Abeta-aggregation Organochlorine
CHEMBL3393736	ACHE BCHE	Acridine Derivative of Tacrine Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget Hydroxycinnamic-ester Antioxidant Cinnamate Dihydroxyphenyl Organochlorine
CHEMBL361165	ACHE	Phenanthridinium Phenanthrene Derivative of Propidium Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget
CHEMBL179455	ACHE	Acridine Phenanthridinium Phenanthrene Derivative of Tacrine Derivative of Propidium Alkyl linked bis-ligand anti-Abeta-aggregation Multitarget
Methoxybenzoxazol-tacrine-cpd44	ACHE	Benzoxazol Derivative of Tacrine Acridine Multitarget GSK-3 kinase inhibitor anti-Abeta-aggregation
Benzylpiperazinephenyl-phenyl-pyrazol-cpd48	BCHE	Multitarget BACE1-inhibitor anti-Abeta-aggregation Piperazine Pyrazole
Isatin-1,3,5-triazine-benzylamine	ACHE	Multitarget Triazine anti-Abeta-aggregation Indole Isatin
SCHEMBL24050193	BCHE	Fluoren Cyclopropyl Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor
Diarylurea-hydroxyamidine-3q	BCHE	Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Diarylurea-hydroxyamidine-6e	BCHE	Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Ferulic-Acid-Piperazine-Cpd13a	ACHE	Multitarget Piperazine Quinoline Feruloyl Metal ion chelator anti-Abeta-aggregation Antioxidant
RIV-IND-5b2	ACHE	Monoamine-oxidase-inhibitor Multitarget Derivative of Rivastigmine Stigmine Indole anti-Abeta-aggregation Antioxidant
TAC-BIM-11d	ACHE	Derivative of Tacrine Acridine Benzimidazole Carboxamide Multitarget anti-Abeta-aggregation Organochlorine
CHDA	ACHE	Derivative of Tacrine Acridine Azepane anti-Abeta-aggregation Multitarget Organochlorine
AChE-HDAC-IN-1	ACHE BCHE	Multitarget HDAC inhibitor Derivative of Tacrine Acridine anti-Abeta-aggregation Antioxidant Organochlorine
HDAC6-IN-5	ACHE	Multitarget HDAC inhibitor Derivative of Tacrine Acridine anti-Abeta-aggregation
AP2238	ACHE	Multitarget Coumarin anti-Abeta-aggregation Chromen
Coumarin-phosphazide-Cpd8b	ACHE BCHE	Multitarget Coumarin anti-Abeta-aggregation Chromen Hydrazinylidene Hydrazide Diazenyl
6-(4-4-phenethylpiperazin-1-yl)heptyl-THAI-14d	BCHE	Indole Azepane Piperazine Multitarget Alkyl linked bis-ligand anti-Abeta-aggregation
Amiridine-thiouracil-13c	BCHE	Quinoline Derivative of Tacrine Derivative of Amiridine Pyrimidine Sulfur Compound anti-Abeta-aggregation Multitarget
CHEMBL5206601	ACHE	anti-Abeta-aggregation Multitarget Pyridine Pyridinium Dimethoxyphenyl
Genistein-O-alkylbenzylamine-25d	ACHE	Multitarget Monoamine-oxidase-inhibitor anti-Abeta-aggregation Chromen Antioxidant
1d-phosphoryl-dihydroacridine	BCHE ACHE	Acridine Derivative of Tacrine Antioxidant anti-Abeta-aggregation Multitarget
tacrine-isatin-Cpd7k	ACHE	anti-Abeta-aggregation Derivative of Tacrine Acridine Multitarget Alkyl linked bis-ligand Indole Isatin Organochlorine
tacrine-isatin-Cpd7d	BCHE	anti-Abeta-aggregation Derivative of Tacrine Acridine Multitarget Alkyl linked bis-ligand Indole Isatin
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol	ACHE	anti-Abeta-aggregation Sulfur Compound BACE1-inhibitor Piperidine Multitarget Carboxamide Oxadiazol Derivative of Donepezil Cyanide Benzylpiperidine
Compound19n-quinolinol	ACHE	Trifluoro anti-Abeta-aggregation Metal ion chelator Quinoline Multitarget Derivative of Donepezil
Donepezil-idebenone-cpd9	BCHE	Multitarget Antioxidant anti-Abeta-aggregation Derivative of Donepezil
Phenothiazine-Tacrine-1dC	ACHE	Phenothiazine Multitarget Derivative of Tacrine Antioxidant Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Sulfur Compound Organochlorine
Tacrine-dipicolylamine-13a	ACHE	Derivative of Tacrine Acridine Alkyl linked bis-ligand Multitarget anti-Abeta-aggregation
Tetracyclic-triterpene-36e	ACHE	Terpenoid Natural_modified anti-Abeta-aggregation Sulfur Compound Multitarget
Cpd17-Tacrine-5-HT6	ACHE BCHE	Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd35-Rivastigmine-5-HT6	BCHE	Derivative of Rivastigmine Stigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
MTDL-cpd51-diphenylacetamide	BCHE	Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide
MTDL-cpd36-diphenylacetamide	BCHE	Multitarget BACE1-inhibitor anti-Abeta-aggregation GABA-transporter-inhibitor Diphenylacetamide tert-Butyl
Ass-IN-10	BCHE	Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
SCHEMBL24135488	ACHE BCHE	Multitarget Calcium Channel Antagonist anti-Abeta-aggregation Derivative of Donepezil Histamine-Receptor3-H3-Antagonist Benzylpiperidine
BIGI-3h	ACHE BCHE	Multitarget Monoamine-oxidase-inhibitor GSK-3 kinase inhibitor Calcium Channel Antagonist anti-Abeta-aggregation Benzylpiperidine Derivative of Donepezil Organochlorine
Chlorotacrine-tryptophan-hybrid	ACHE BCHE	Derivative of Tacrine Acridine Multitarget Indole anti-Abeta-aggregation Alkyl linked bis-ligand Organochlorine
Quinolinetrione-tacrine-Cpd3	ACHE	Quinoline Multitarget Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation
Chlorotacrine-juglone	ACHE	Multitarget Antioxidant Derivative of Tacrine Acridine Alkyl linked bis-ligand anti-Abeta-aggregation Naphthalen Organochlorine
SB-1436	BCHE ACHE	Pyridine Naphthalen Pyridinium anti-Abeta-aggregation Multitarget Organochlorine