JJH251

Broad spectrum inhibitor of serine hydrolase ABHD4

General

Type : Carbamate, Piperidine, N-hydroxyhydantoin

Chemical_Nomenclature : [7-[(4-bromophenyl)methyl]-1,3-dioxo-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl] 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate

Canonical SMILES : C1CN(CCC1CCC2=CC=C(C=C2)Cl)C(=O)ON3C(=O)C4CN(CCN4C3=O)CC5=CC=C(C=C5)Br

InChI : InChI=1S\/C27H30BrClN4O4\/c28-22-7-3-21(4-8-22)17-30-15-16-32-24(18-30)25(34)33(26(32)35)37-27(36)31-13-11-20(12-14-31)2-1-19-5-9-23(29)10-6-19\/h3-10,20,24H,1-2,11-18H2

InChIKey : ROMFPQLOEVFKDY-UHFFFAOYSA-N

Other name(s) : SCHEMBL17275279  ||  SR-02000002580  ||  SR-02000002580-1


MW : 589.9

Formula : C27H30BrClN4O4

CAS_number :

PubChem : 71710937

UniChem : ROMFPQLOEVFKDY-UHFFFAOYSA-N

Target

References (1)

Title : AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs - Parsons_2016_Nat.Chem.Biol_12_367
Author(s) : Parsons WH , Kolar MJ , Kamat SS , Cognetta AB, 3rd , Hulce JJ , Saez E , Kahn BB , Saghatelian A , Cravatt BF
Ref : Nat Chemical Biology , 12 :367 , 2016
Abstract :
PubMedSearch : Parsons_2016_Nat.Chem.Biol_12_367
PubMedID: 27018888