Full name : Cravatt Benjamin F
First name : Benjamin F
Mail : Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92307
Zip Code :
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Country : USA
Email : cravatt@scripps.edu
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Comment
| Title : A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation - League_2024_Front.Immunol_15_1374301 |
| Author(s) : League AF , Yadav-Samudrala BJ , Kolagani R , Cline CA , Jacobs IR , Manke J , Niphakis MJ , Cravatt BF , Lichtman AH , Ignatowska-Jankowska BM , Fitting S |
| Ref : Front Immunol , 15 :1374301 , 2024 |
| Abstract : |
| PubMedSearch : League_2024_Front.Immunol_15_1374301 |
| PubMedID: 38835765 |
| Gene_locus related to this paper: human-MGLL |
| Title : Attenuating ABHD17 enhances S- palmitoylation, membrane localization and signal transduction of NOD2 and Crohn's disease-associated variants - Dixon_2023_bioRxiv__ |
| Author(s) : Dixon CL , Martin NR , Niphakis MJ , Cravatt BF , Fairn GD |
| Ref : Biorxiv , : , 2023 |
| Abstract : |
| PubMedSearch : Dixon_2023_bioRxiv__ |
| PubMedID: 38187608 |
| Title : Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviors and drinking in Marchigian Sardinian alcohol-preferring rats - Vozella_2023_Br.J.Pharmacol__ |
| Author(s) : Vozella V , Cruz B , Feldman HC , Bullard R , Bianchi PC , Natividad LA , Cravatt BF , Zorrilla EP , Ciccocioppo R , Roberto M |
| Ref : British Journal of Pharmacology , : , 2023 |
| Abstract : |
| PubMedSearch : Vozella_2023_Br.J.Pharmacol__ |
| PubMedID: 37488777 |
| Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R |
| Ref : Angew Chem Int Ed Engl , : , 2022 |
| Abstract : |
| PubMedSearch : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| PubMedID: 36089535 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms - Xu_2022_Cells_11_ |
| Author(s) : Xu C , Yadav-Samudrala BJ , Nath B , Mistry T , Jiang W , Niphakis MJ , Cravatt BF , Mukhopadhyay S , Lichtman AH , Ignatowska-Jankowska BM , Fitting S |
| Ref : Cells , 11 : , 2022 |
| Abstract : |
| PubMedSearch : Xu_2022_Cells_11_ |
| PubMedID: 35269478 |
| Title : Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling - Li_2022_Cell.Chem.Biol_29_883 |
| Author(s) : Li M , Patel HV , Cognetta AB, 3rd , Smith TC, 2nd , Mallick I , Cavalier JF , Previti ML , Canaan S , Aldridge BB , Cravatt BF , Seeliger JC |
| Ref : Cell Chemical Biology , 29 :883 , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_Cell.Chem.Biol_29_883 |
| PubMedID: 34599873 |
| Title : In situ identification of cellular drug targets in mammalian tissue - Pang_2022_Cell_185_1793 |
| Author(s) : Pang Z , Schafroth MA , Ogasawara D , Wang Y , Nudell V , Lal NK , Yang D , Wang K , Herbst DM , Ha J , Guijas C , Blankman JL , Cravatt BF , Ye L |
| Ref : Cell , 185 :1793 , 2022 |
| Abstract : |
| PubMedSearch : Pang_2022_Cell_185_1793 |
| PubMedID: 35483372 |
| Title : Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation - Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| Author(s) : Suciu RM , Luvaga IK , Hazeen A , Weerasooriya C , Richardson SK , Firestone AJ , Shannon K , Howell AR , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 53 :128414 , 2021 |
| Abstract : |
| PubMedSearch : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| PubMedID: 34666187 |
| Title : Sex-dependent effects of endocannabinoid modulation of conditioned fear extinction in rats - Morena_2021_Br.J.Pharmacol_178_983 |
| Author(s) : Morena M , Nastase AS , Santori A , Cravatt BF , Shansky RM , Hill MN |
| Ref : British Journal of Pharmacology , 178 :983 , 2021 |
| Abstract : |
| PubMedSearch : Morena_2021_Br.J.Pharmacol_178_983 |
| PubMedID: 33314038 |
| Title : Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex - Pavon_2021_Neurobiol.Stress_14_100293 |
| Author(s) : Pavon FJ , Polis IY , Stouffer DG , Cravatt BF , Roberto M , Martin-Fardon R , Rodriguez de Fonseca F , Parsons LH , Serrano A |
| Ref : Neurobiol Stress , 14 :100293 , 2021 |
| Abstract : |
| PubMedSearch : Pavon_2021_Neurobiol.Stress_14_100293 |
| PubMedID: 33490317 |
| Gene_locus related to this paper: human-MGLL |
| Title : Diacylglycerol Lipase-beta Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences - O'Brien_2021_Cannabis.Cannabinoid.Res__ |
| Author(s) : O'Brien LD , Smith TL , Donvito G , Cravatt BF , Newton J , Spiegel S , Reeves TM , Phillips LL , Lichtman AH |
| Ref : Cannabis Cannabinoid Res , : , 2021 |
| Abstract : |
| PubMedSearch : O'Brien_2021_Cannabis.Cannabinoid.Res__ |
| PubMedID: 34142866 |
| Gene_locus related to this paper: human-DAGLB , mouse-DGLB |
| Title : Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold - Rong_2021_J.Med.Chem__ |
| Author(s) : Rong J , Mori W , Xia X , Schafroth MA , Zhao C , Van RS , Yamasaki T , Chen J , Xiao Z , Haider A , Ogasawara D , Hiraishi A , Shao T , Zhang Y , Chen Z , Pang F , Hu K , Xie L , Fujinaga M , Kumata K , Gou Y , Fang Y , Gu S , Wei H , Bao L , Xu H , Collier TL , Shao Y , Carson RE , Cravatt BF , Wang L , Zhang MR , Liang SH |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Rong_2021_J.Med.Chem__ |
| PubMedID: 34569803 |
| Gene_locus related to this paper: human-MGLL |
| Title : Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat - League_2021_Front.Neurol_12_651272 |
| Author(s) : League AF , Gorman BL , Hermes DJ , Johnson CT , Jacobs IR , Yadav-Samudrala BJ , Poklis JL , Niphakis MJ , Cravatt BF , Lichtman AH , Ignatowska-Jankowska BM , Fitting S |
| Ref : Front Neurol , 12 :651272 , 2021 |
| Abstract : |
| PubMedSearch : League_2021_Front.Neurol_12_651272 |
| PubMedID: 34484091 |
| Gene_locus related to this paper: human-MGLL |
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Profiling of MicroRNA Targets Using Activity-Based Protein Profiling: Linking Enzyme Activity to MicroRNA-185 Function - Filip_2021_Cell.Chem.Biol_28_202 |
| Author(s) : Filip R , Desrochers GF , Lefebvre DM , Reed A , Singaravelu R , Cravatt BF , Pezacki JP |
| Ref : Cell Chemical Biology , 28 :202 , 2021 |
| Abstract : |
| PubMedSearch : Filip_2021_Cell.Chem.Biol_28_202 |
| PubMedID: 33450181 |
| Title : An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides - Grevengoed_2021_J.Clin.Invest_131_ |
| Author(s) : Grevengoed TJ , Trammell SA , Svenningsen JS , Makarov MV , Nielsen TS , Jacobsen JCB , Treebak JT , Calder PC , Migaud ME , Cravatt BF , Gillum MP |
| Ref : J Clinical Investigation , 131 : , 2021 |
| Abstract : |
| PubMedSearch : Grevengoed_2021_J.Clin.Invest_131_ |
| PubMedID: 33507883 |
| Title : Development of a highly-specific (18)F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping - Chen_2021_Acta.Pharm.Sin.B_11_1686 |
| Author(s) : Chen Z , Mori W , Rong J , Schafroth MA , Shao T , Van RS , Ogasawara D , Yamasaki T , Hiraishi A , Hatori A , Chen J , Zhang Y , Hu K , Fujinaga M , Sun J , Yu Q , Collier TL , Shao Y , Cravatt BF , Josephson L , Zhang MR , Liang SH |
| Ref : Acta Pharm Sin B , 11 :1686 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_Acta.Pharm.Sin.B_11_1686 |
| PubMedID: 34221877 |
| Gene_locus related to this paper: human-MGLL |
| Title : Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function - Rosier_2021_iScience_24_103460 |
| Author(s) : Rosier K , McDevitt MT , Smet J , Floyd BJ , Verschoore M , Marcaida MJ , Bingman CA , Lemmens I , Dal Peraro M , Tavernier J , Cravatt BF , Gounko NV , Vints K , Monnens Y , Bhalla K , Aerts L , Rashan EH , Vanlander AV , Van Coster R , Regal L , Pagliarini DJ , Creemers JWM |
| Ref : iScience , 24 :103460 , 2021 |
| Abstract : |
| PubMedSearch : Rosier_2021_iScience_24_103460 |
| PubMedID: 34888501 |
| Gene_locus related to this paper: human-PREPL |
| Title : Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development - Hou_2021_J.Med.Chem_64_123 |
| Author(s) : Hou L , Rong J , Haider A , Ogasawara D , Varlow C , Schafroth MA , Mu L , Gan J , Xu H , Fowler CJ , Zhang MR , Vasdev N , Ametamey S , Cravatt BF , Wang L , Liang SH |
| Ref : Journal of Medicinal Chemistry , 64 :123 , 2021 |
| Abstract : |
| PubMedSearch : Hou_2021_J.Med.Chem_64_123 |
| PubMedID: 33379862 |
| Title : Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells - Kathman_2020_ACS.Chem.Biol_15_871 |
| Author(s) : Kathman SG , Boshart J , Jing H , Cravatt BF |
| Ref : ACS Chemical Biology , 15 :871 , 2020 |
| Abstract : |
| PubMedSearch : Kathman_2020_ACS.Chem.Biol_15_871 |
| PubMedID: 32195565 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice - Zambetti_2020_Blood_135_1772 |
| Author(s) : Zambetti NA , Firestone AJ , Remsberg JR , Huang BJ , Wong JC , Long AM , Predovic M , Suciu RM , Inguva A , Kogan SC , Haigis KM , Cravatt BF , Shannon K |
| Ref : Blood , 135 :1772 , 2020 |
| Abstract : |
| PubMedSearch : Zambetti_2020_Blood_135_1772 |
| PubMedID: 32219446 |
| Title : ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease - Ichu_2020_Biochemistry_59_1793 |
| Author(s) : Ichu TA , Reed A , Ogasawara D , Ulanovskaya O , Roberts A , Aguirre CA , Bar-Peled L , Gao J , Germain J , Barbas S , Masuda K , Conti B , Tontonoz P , Cravatt BF |
| Ref : Biochemistry , 59 :1793 , 2020 |
| Abstract : |
| PubMedSearch : Ichu_2020_Biochemistry_59_1793 |
| PubMedID: 32364701 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator - Mizrak_2020_Cell.Rep_31_107805 |
| Author(s) : Mizrak D , Bayin NS , Yuan J , Liu Z , Suciu RM , Niphakis MJ , Ngo N , Lum KM , Cravatt BF , Joyner AL , Sims PA |
| Ref : Cell Rep , 31 :107805 , 2020 |
| Abstract : |
| PubMedSearch : Mizrak_2020_Cell.Rep_31_107805 |
| PubMedID: 32579931 |
| Gene_locus related to this paper: human-NOTUM |
| Title : ABHD4-dependent developmental anoikis safeguards the embryonic brain - Laszlo_2020_Nat.Commun_11_4363 |
| Author(s) : Laszlo ZI , Lele Z , Zoldi M , Miczan V , Mogor F , Simon GM , Mackie K , Kacskovics I , Cravatt BF , Katona I |
| Ref : Nat Commun , 11 :4363 , 2020 |
| Abstract : |
| PubMedSearch : Laszlo_2020_Nat.Commun_11_4363 |
| PubMedID: 32868797 |
| Gene_locus related to this paper: human-ABHD4 , mouse-abhd4 |
| Title : Discovery of small-molecule enzyme activators by activity-based protein profiling - Kok_2020_Nat.Chem.Biol_16_997 |
| Author(s) : Kok BP , Ghimire S , Kim W , Chatterjee S , Johns T , Kitamura S , Eberhardt J , Ogasawara D , Xu J , Sukiasyan A , Kim SM , Godio C , Bittencourt JM , Cameron M , Galmozzi A , Forli S , Wolan DW , Cravatt BF , Boger DL , Saez E |
| Ref : Nat Chemical Biology , 16 :997 , 2020 |
| Abstract : |
| PubMedSearch : Kok_2020_Nat.Chem.Biol_16_997 |
| PubMedID: 32514184 |
| Gene_locus related to this paper: human-LYPLAL1 |
| Title : 3-Oxo-beta-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling - Carvalho_2020_ACS.Chem.Biol_15_878 |
| Author(s) : Carvalho LAR , Almeida VT , Brito JA , Lum KM , Oliveira TF , Guedes RC , Goncalves LM , Lucas SD , Cravatt BF , Archer M , Moreira R |
| Ref : ACS Chemical Biology , 15 :878 , 2020 |
| Abstract : |
| PubMedSearch : Carvalho_2020_ACS.Chem.Biol_15_878 |
| PubMedID: 32176480 |
| Title : AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice - Erikci_2020_J.Biol.Chem_295_5891 |
| Author(s) : Erikci Ertunc M , Kok BP , Parsons WH , Wang JG , Tan D , Donaldson CJ , Pinto AFM , Vaughan JM , Ngo N , Lum KM , Henry CL , Coppola AR , Niphakis MJ , Cravatt BF , Saez E , Saghatelian A |
| Ref : Journal of Biological Chemistry , 295 :5891 , 2020 |
| Abstract : |
| PubMedSearch : Erikci_2020_J.Biol.Chem_295_5891 |
| PubMedID: 32152231 |
| Title : The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors - Feja_2020_Neuropharmacol_162_107814 |
| Author(s) : Feja M , Leigh MPK , Baindur AN , McGraw JJ , Wakabayashi KT , Cravatt BF , Bass CE |
| Ref : Neuropharmacology , 162 :107814 , 2020 |
| Abstract : |
| PubMedSearch : Feja_2020_Neuropharmacol_162_107814 |
| PubMedID: 31628934 |
| Gene_locus related to this paper: human-MGLL |
| Title : The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain - Thompson_2020_J.Pharmacol.Exp.Ther_373_230 |
| Author(s) : Thompson AL , Grenald SA , Ciccone HA , BassiriRad N , Niphakis MJ , Cravatt BF , Largent-Milnes TM , Vanderah TW |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 373 :230 , 2020 |
| Abstract : |
| PubMedSearch : Thompson_2020_J.Pharmacol.Exp.Ther_373_230 |
| PubMedID: 32054717 |
| Gene_locus related to this paper: human-MGLL |
| Title : Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice - Muldoon_2020_Neuropharmacol__108170 |
| Author(s) : Muldoon PP , Akinola LS , Schlosburg JE , Lichtman AH , Sim-Selley LJ , Mahadevan A , Cravatt BF , Damaj MI |
| Ref : Neuropharmacology , :108170 , 2020 |
| Abstract : |
| PubMedSearch : Muldoon_2020_Neuropharmacol__108170 |
| PubMedID: 32479813 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan - Chen_2019_Nat.Chem.Biol_15_453 |
| Author(s) : Chen AL , Lum KM , Lara-Gonzalez P , Ogasawara D , Cognetta AB, 3rd , To A , Parsons WH , Simon GM , Desai A , Petrascheck M , Bar-Peled L , Cravatt BF |
| Ref : Nat Chemical Biology , 15 :453 , 2019 |
| Abstract : |
| PubMedSearch : Chen_2019_Nat.Chem.Biol_15_453 |
| PubMedID: 30911178 |
| Title : Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase alpha\/beta-Hydrolase Domain-Containing 12 (ABHD12) - Ogasawara_2019_J.Med.Chem_62_1643 |
| Author(s) : Ogasawara D , Ichu TA , Jing H , Hulce JJ , Reed A , Ulanovskaya OA , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 62 :1643 , 2019 |
| Abstract : |
| PubMedSearch : Ogasawara_2019_J.Med.Chem_62_1643 |
| PubMedID: 30720278 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Design, Synthesis, and Evaluation of (18)F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes - Chen_2019_J.Med.Chem_62_8866 |
| Author(s) : Chen Z , Mori W , Fu H , Schafroth MA , Hatori A , Shao T , Zhang G , Van RS , Zhang Y , Hu K , Fujinaga M , Wang L , Belov V , Ogasawara D , Giffenig P , Deng X , Rong J , Yu Q , Zhang X , Papisov MI , Shao Y , Collier TL , Ma JA , Cravatt BF , Josephson L , Zhang MR , Liang SH |
| Ref : Journal of Medicinal Chemistry , 62 :8866 , 2019 |
| Abstract : |
| PubMedSearch : Chen_2019_J.Med.Chem_62_8866 |
| PubMedID: 31518130 |
| Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398 |
| Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P |
| Ref : Nature , 571 :398 , 2019 |
| Abstract : |
| PubMedSearch : Pentinmikko_2019_Nature_571_398 |
| PubMedID: 31292548 |
| Gene_locus related to this paper: human-NOTUM , mouse-notum |
| Title : Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner - |
| Author(s) : Guillamat Prats R , Rami M , Ring L , Rinne P , Lauer E , Lenglet S , Thomas A , Pagano S , Vuilleumier N , Cravatt BF , Weber C , Faussner A , Steffens S |
| Ref : Thromb Haemost , 119 :348 , 2019 |
| PubMedID: 30609444 |
| Title : Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice - Pavon_2019_Addict.Biol_24_1204 |
| Author(s) : Pavon FJ , Serrano A , Stouffer DG , Polis I , Roberto M , Cravatt BF , Martin-Fardon R , Rodriguez de Fonseca F , Parsons LH |
| Ref : Addict Biol , 24 :1204 , 2019 |
| Abstract : |
| PubMedSearch : Pavon_2019_Addict.Biol_24_1204 |
| PubMedID: 30421483 |
| Title : Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats - Sticht_2019_Br.J.Pharmacol_176_1524 |
| Author(s) : Sticht MA , Lau DJ , Keenan CM , Cavin JB , Morena M , Vemuri VK , Makriyannis A , Cravatt BF , Sharkey KA , Hill MN |
| Ref : British Journal of Pharmacology , 176 :1524 , 2019 |
| Abstract : |
| PubMedSearch : Sticht_2019_Br.J.Pharmacol_176_1524 |
| PubMedID: 30051485 |
| Title : Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver - Habib_2019_Gut_68_522 |
| Author(s) : Habib A , Chokr D , Wan J , Hegde P , Mabire M , Siebert M , Ribeiro-Parenti L , Le Gall M , Letteron P , Pilard N , Mansouri A , Brouillet A , Tardelli M , Weiss E , Le Faouder P , Guillou H , Cravatt BF , Moreau R , Trauner M , Lotersztajn S |
| Ref : Gut , 68 :522 , 2019 |
| Abstract : |
| PubMedSearch : Habib_2019_Gut_68_522 |
| PubMedID: 30301768 |
| Title : N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases - Otrubova_2019_Bioorg.Med.Chem_27_1693 |
| Author(s) : Otrubova K , Chatterjee S , Ghimire S , Cravatt BF , Boger DL |
| Ref : Bioorganic & Medicinal Chemistry , 27 :1693 , 2019 |
| Abstract : |
| PubMedSearch : Otrubova_2019_Bioorg.Med.Chem_27_1693 |
| PubMedID: 30879861 |
| Title : N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis - Grevengoed_2019_Proc.Natl.Acad.Sci.U.S.A_116_24770 |
| Author(s) : Grevengoed TJ , Trammell SAJ , McKinney MK , Petersen N , Cardone RL , Svenningsen JS , Ogasawara D , Nexoe-Larsen CC , Knop FK , Schwartz TW , Kibbey RG , Cravatt BF , Gillum MP |
| Ref : Proc Natl Acad Sci U S A , 116 :24770 , 2019 |
| Abstract : |
| PubMedSearch : Grevengoed_2019_Proc.Natl.Acad.Sci.U.S.A_116_24770 |
| PubMedID: 31740614 |
| Title : Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a Tail Switching Strategy on a Piperazinyl Azetidine Skeleton - Chen_2019_J.Med.Chem_62_3336 |
| Author(s) : Chen Z , Mori W , Deng X , Cheng R , Ogasawara D , Zhang G , Schafroth MA , Dahl K , Fu H , Hatori A , Shao T , Zhang Y , Yamasaki T , Zhang X , Rong J , Yu Q , Hu K , Fujinaga M , Xie L , Kumata K , Gou Y , Chen J , Gu S , Bao L , Wang L , Collier TL , Vasdev N , Shao Y , Ma JA , Cravatt BF , Fowler C , Josephson L , Zhang MR , Liang SH |
| Ref : Journal of Medicinal Chemistry , 62 :3336 , 2019 |
| Abstract : |
| PubMedSearch : Chen_2019_J.Med.Chem_62_3336 |
| PubMedID: 30829483 |
| Gene_locus related to this paper: human-MGLL |
| Title : Diacylglycerol Lipase-Alpha Regulates Hippocampal-Dependent Learning and Memory Processes in Mice - Schurman_2019_J.Neurosci_39_5949 |
| Author(s) : Schurman LD , Carper MC , Moncayo LV , Ogasawara D , Richardson K , Yu L , Liu X , Poklis JL , Liu QS , Cravatt BF , Lichtman AH |
| Ref : Journal of Neuroscience , 39 :5949 , 2019 |
| Abstract : |
| PubMedSearch : Schurman_2019_J.Neurosci_39_5949 |
| PubMedID: 31127001 |
| Gene_locus related to this paper: mouse-q6wqj1 |
| Title : Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake - Serrano_2018_Neuropsychopharmacology_43_1840 |
| Author(s) : Serrano A , Pavon FJ , Buczynski MW , Schlosburg J , Natividad LA , Polis IY , Stouffer DG , Zorrilla EP , Roberto M , Cravatt BF , Martin-Fardon R , Rodriguez de Fonseca F , Parsons LH |
| Ref : Neuropsychopharmacology , 43 :1840 , 2018 |
| Abstract : |
| PubMedSearch : Serrano_2018_Neuropsychopharmacology_43_1840 |
| PubMedID: 29748627 |
| Title : Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex - McReynolds_2018_Biol.Psychiatry_84_85 |
| Author(s) : McReynolds JR , Doncheck EM , Li Y , Vranjkovic O , Graf EN , Ogasawara D , Cravatt BF , Baker DA , Liu QS , Hillard CJ , Mantsch JR |
| Ref : Biological Psychiatry , 84 :85 , 2018 |
| Abstract : |
| PubMedSearch : McReynolds_2018_Biol.Psychiatry_84_85 |
| PubMedID: 29100630 |
| Title : Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis - Manterola_2018_Neuropharmacol_141_181 |
| Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Ruiz A , Perez-Samartin A , Moreno-Rodriguez M , Hsu KL , Cravatt BF , Brown JM , Rodriguez-Puertas R , Matute C , Mato S |
| Ref : Neuropharmacology , 141 :181 , 2018 |
| Abstract : |
| PubMedSearch : Manterola_2018_Neuropharmacol_141_181 |
| PubMedID: 30171986 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo - Ogasawara_2018_Nat.Chem.Biol_14_1099 |
| Author(s) : Ogasawara D , Ichu TA , Vartabedian VF , Benthuysen J , Jing H , Reed A , Ulanovskaya OA , Hulce JJ , Roberts A , Brown S , Rosen H , Teijaro JR , Cravatt BF |
| Ref : Nat Chemical Biology , 14 :1099 , 2018 |
| Abstract : |
| PubMedSearch : Ogasawara_2018_Nat.Chem.Biol_14_1099 |
| PubMedID: 30420694 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling - Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| Author(s) : Suciu RM , Cognetta AB, 3rd , Potter ZE , Cravatt BF |
| Ref : ACS Med Chem Lett , 9 :563 , 2018 |
| Abstract : |
| PubMedSearch : Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| PubMedID: 29937983 |
| Gene_locus related to this paper: human-NOTUM |
| Title : In Vitro and in Vivo Evaluation of (11)C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies - Cheng_2018_J.Med.Chem_61_2278 |
| Author(s) : Cheng R , Mori W , Ma L , Alhouayek M , Hatori A , Zhang Y , Ogasawara D , Yuan G , Chen Z , Zhang X , Shi H , Yamasaki T , Xie L , Kumata K , Fujinaga M , Nagai Y , Minamimoto T , Svensson M , Wang L , Du Y , Ondrechen MJ , Vasdev N , Cravatt BF , Fowler C , Zhang MR , Liang SH |
| Ref : Journal of Medicinal Chemistry , 61 :2278 , 2018 |
| Abstract : |
| PubMedSearch : Cheng_2018_J.Med.Chem_61_2278 |
| PubMedID: 29481079 |
| Title : Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments - Galmozzi_2018_Methods.Mol.Biol_1787_115 |
| Author(s) : Galmozzi A , Parker CG , Kok BP , Cravatt BF , Saez E |
| Ref : Methods Mol Biol , 1787 :115 , 2018 |
| Abstract : |
| PubMedSearch : Galmozzi_2018_Methods.Mol.Biol_1787_115 |
| PubMedID: 29736714 |
| Title : Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens - Pavon_2018_Addict.Biol_23_723 |
| Author(s) : Pavon FJ , Serrano A , Sidhpura N , Polis I , Stouffer D , de Fonseca FR , Cravatt BF , Martin-Fardon R , Parsons LH |
| Ref : Addict Biol , 23 :723 , 2018 |
| Abstract : |
| PubMedSearch : Pavon_2018_Addict.Biol_23_723 |
| PubMedID: 28660730 |
| Title : Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy - Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| Author(s) : Curry ZA , Wilkerson JL , Bagdas D , Kyte SL , Patel N , Donvito G , Mustafa MA , Poklis JL , Niphakis MJ , Hsu KL , Cravatt BF , Gewirtz DA , Damaj MI , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 366 :169 , 2018 |
| Abstract : |
| PubMedSearch : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| PubMedID: 29540562 |
| Title : Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer's disease - Aparicio_2018_Biochem.Pharmacol_157_202 |
| Author(s) : Aparicio N , Grande MT , Ruiz de Martin Esteban S , Lopez A , Ruiz-Perez G , Amores M , Vazquez C , Martinez-Relimpio AM , Pazos MR , Cravatt BF , Tolon RM , Romero J |
| Ref : Biochemical Pharmacology , 157 :202 , 2018 |
| Abstract : |
| PubMedSearch : Aparicio_2018_Biochem.Pharmacol_157_202 |
| PubMedID: 30195729 |
| Title : The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase - Inloes_2018_Biochemistry_57_5759 |
| Author(s) : Inloes JM , Jing H , Cravatt BF |
| Ref : Biochemistry , 57 :5759 , 2018 |
| Abstract : |
| PubMedSearch : Inloes_2018_Biochemistry_57_5759 |
| PubMedID: 30221923 |
| Title : Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets - Inloes_2018_Biochemistry_57_827 |
| Author(s) : Inloes JM , Kiosses WB , Wang H , Walther TC , Farese RV, Jr. , Cravatt BF |
| Ref : Biochemistry , 57 :827 , 2018 |
| Abstract : |
| PubMedSearch : Inloes_2018_Biochemistry_57_827 |
| PubMedID: 29278326 |
| Title : Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2 - Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| Author(s) : Yun B , Lee H , Powell R , Reisdorph N , Ewing H , Gelb MH , Hsu KL , Cravatt BF , Leslie CC |
| Ref : Biochemical & Biophysical Research Communications , 490 :1226 , 2017 |
| Abstract : |
| PubMedSearch : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedID: 28684316 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 - van Esbroeck_2017_Science_356_1084 |
| Author(s) : van Esbroeck ACM , Janssen APA , Cognetta AB, 3rd , Ogasawara D , Shpak G , van der Kroeg M , Kantae V , Baggelaar MP , de Vrij FMS , Deng H , Allara M , Fezza F , Lin Z , van der Wel T , Soethoudt M , Mock ED , den Dulk H , Baak IL , Florea BI , Hendriks G , De Petrocellis L , Overkleeft HS , Hankemeier T , De Zeeuw CI , Di Marzo V , Maccarrone M , Cravatt BF , Kushner SA , van der Stelt M |
| Ref : Science , 356 :1084 , 2017 |
| Abstract : |
| PubMedSearch : van Esbroeck_2017_Science_356_1084 |
| PubMedID: 28596366 |
| Title : Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors - Tan_2017_Nat.Commun_8_1760 |
| Author(s) : Tan J , Cognetta AB, 3rd , Diaz DB , Lum KM , Adachi S , Kundu S , Cravatt BF , Yudin AK |
| Ref : Nat Commun , 8 :1760 , 2017 |
| Abstract : |
| PubMedSearch : Tan_2017_Nat.Commun_8_1760 |
| PubMedID: 29170371 |
| Gene_locus related to this paper: human-ABHD3 , mouse-abhd3 |
| Title : Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor - Kornahrens_2017_J.Am.Chem.Soc_139_7052 |
| Author(s) : Kornahrens AF , Cognetta AB, 3rd , Brody DM , Matthews ML , Cravatt BF , Boger DL |
| Ref : Journal of the American Chemical Society , 139 :7052 , 2017 |
| Abstract : |
| PubMedSearch : Kornahrens_2017_J.Am.Chem.Soc_139_7052 |
| PubMedID: 28498651 |
| Title : Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice - Owens_2017_Neuropharmacol_125_80 |
| Author(s) : Owens RA , Mustafa MA , Ignatowska-Jankowska BM , Damaj MI , Beardsley PM , Wiley JL , Niphakis MJ , Cravatt BF , Lichtman AH |
| Ref : Neuropharmacology , 125 :80 , 2017 |
| Abstract : |
| PubMedSearch : Owens_2017_Neuropharmacol_125_80 |
| PubMedID: 28673548 |
| Title : The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice - Wilkerson_2017_Neuropharmacol_114_156 |
| Author(s) : Wilkerson JL , Ghosh S , Mustafa M , Abdullah RA , Niphakis MJ , Cabrera R , Maldonado RL , Cravatt BF , Lichtman AH |
| Ref : Neuropharmacology , 114 :156 , 2017 |
| Abstract : |
| PubMedSearch : Wilkerson_2017_Neuropharmacol_114_156 |
| PubMedID: 27890602 |
| Title : Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation - Shimanaka_2017_Nat.Med_23_1287 |
| Author(s) : Shimanaka Y , Kono N , Taketomi Y , Arita M , Okayama Y , Tanaka Y , Nishito Y , Mochizuki T , Kusuhara H , Adibekian A , Cravatt BF , Murakami M , Arai H |
| Ref : Nat Med , 23 :1287 , 2017 |
| Abstract : |
| PubMedSearch : Shimanaka_2017_Nat.Med_23_1287 |
| PubMedID: 29035365 |
| Gene_locus related to this paper: human-PAFAH2 |
| Title : A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A - Touchette_2017_ACS.Infect.Dis_3_336 |
| Author(s) : Touchette MH , Van Vlack ER , Bai L , Kim J , Cognetta AB, 3rd , Previti ML , Backus KM , Martin DW , Cravatt BF , Seeliger JC |
| Ref : ACS Infect Dis , 3 :336 , 2017 |
| Abstract : |
| PubMedSearch : Touchette_2017_ACS.Infect.Dis_3_336 |
| PubMedID: 28276676 |
| Gene_locus related to this paper: myctu-a85a |
| Title : Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism - Kory_2017_J.Lipid.Res_58_226 |
| Author(s) : Kory N , Grond S , Kamat SS , Li Z , Krahmer N , Chitraju C , Zhou P , Frohlich F , Semova I , Ejsing C , Zechner R , Cravatt BF , Farese RV, Jr. , Walther TC |
| Ref : J Lipid Res , 58 :226 , 2017 |
| Abstract : |
| PubMedSearch : Kory_2017_J.Lipid.Res_58_226 |
| PubMedID: 27836991 |
| Gene_locus related to this paper: human-LDAH , mouse-Ldah |
| Title : Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model - Wilkerson_2017_J.Pharmacol.Exp.Ther_363_394 |
| Author(s) : Wilkerson JL , Donvito G , Grim TW , Abdullah RA , Ogasawara D , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 363 :394 , 2017 |
| Abstract : |
| PubMedSearch : Wilkerson_2017_J.Pharmacol.Exp.Ther_363_394 |
| PubMedID: 28970359 |
| Gene_locus related to this paper: mouse-q6wqj1 |
| Title : Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding - Deng_2017_J.Med.Chem_60_428 |
| Author(s) : Deng H , Kooijman S , van den Nieuwendijk AM , Ogasawara D , van der Wel T , van Dalen F , Baggelaar MP , Janssen FJ , van den Berg RJ , den Dulk H , Cravatt BF , Overkleeft HS , Rensen PC , van der Stelt M |
| Ref : Journal of Medicinal Chemistry , 60 :428 , 2017 |
| Abstract : |
| PubMedSearch : Deng_2017_J.Med.Chem_60_428 |
| PubMedID: 27992221 |
| Title : Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure - Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
| Author(s) : Buczynski MW , Herman MA , Hsu KL , Natividad LA , Irimia C , Polis IY , Pugh H , Chang JW , Niphakis MJ , Cravatt BF , Roberto M , Parsons LH |
| Ref : Proc Natl Acad Sci U S A , 113 :1086 , 2016 |
| Abstract : |
| PubMedSearch : Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
| PubMedID: 26755579 |
| Title : Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats - Panlilio_2016_Psychopharmacology.(Berl)_233_1879 |
| Author(s) : Panlilio LV , Thorndike EB , Nikas SP , Alapafuja SO , Bandiera T , Cravatt BF , Makriyannis A , Piomelli D , Goldberg SR , Justinova Z |
| Ref : Psychopharmacology (Berl) , 233 :1879 , 2016 |
| Abstract : |
| PubMedSearch : Panlilio_2016_Psychopharmacology.(Berl)_233_1879 |
| PubMedID: 26558620 |
| Title : Chemical Proteomic Profiling of Human Methyltransferases - Horning_2016_J.Am.Chem.Soc_138_13335 |
| Author(s) : Horning BD , Suciu RM , Ghadiri DA , Ulanovskaya OA , Matthews ML , Lum KM , Backus KM , Brown SJ , Rosen H , Cravatt BF |
| Ref : Journal of the American Chemical Society , 138 :13335 , 2016 |
| Abstract : |
| PubMedSearch : Horning_2016_J.Am.Chem.Soc_138_13335 |
| PubMedID: 27689866 |
| Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M |
| Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016 |
| Abstract : |
| PubMedSearch : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedID: 26668358 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice - Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
| Author(s) : Owens RA , Ignatowska-Jankowska B , Mustafa M , Beardsley PM , Wiley JL , Jali A , Selley DE , Niphakis MJ , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 358 :306 , 2016 |
| Abstract : |
| PubMedSearch : Owens_2016_J.Pharmacol.Exp.Ther_358_306 |
| PubMedID: 27307500 |
| Title : Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum - Chen_2016_eNeuro_3_ |
| Author(s) : Chen Y , Liu X , Vickstrom CR , Liu MJ , Zhao L , Viader A , Cravatt BF , Liu QS |
| Ref : eNeuro , 3 : , 2016 |
| Abstract : |
| PubMedSearch : Chen_2016_eNeuro_3_ |
| PubMedID: 27182552 |
| Title : The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model - Wilkerson_2016_J.Pharmacol.Exp.Ther_357_145 |
| Author(s) : Wilkerson JL , Niphakis MJ , Grim TW , Mustafa MA , Abdullah RA , Poklis JL , Dewey WL , Akbarali H , Banks ML , Wise LE , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 357 :145 , 2016 |
| Abstract : |
| PubMedSearch : Wilkerson_2016_J.Pharmacol.Exp.Ther_357_145 |
| PubMedID: 26791602 |
| Title : Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model - Limebeer_2016_Behav.Neurosci_130_261 |
| Author(s) : Limebeer CL , Rock EM , Puvanenthirarajah N , Niphakis MJ , Cravatt BF , Parker LA |
| Ref : Behavioral Neuroscience , 130 :261 , 2016 |
| Abstract : |
| PubMedSearch : Limebeer_2016_Behav.Neurosci_130_261 |
| PubMedID: 26974857 |
| Title : A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation - Viader_2016_Elife_5_ |
| Author(s) : Viader A , Ogasawara D , Joslyn CM , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Cravatt BF |
| Ref : Elife , 5 : , 2016 |
| Abstract : |
| PubMedSearch : Viader_2016_Elife_5_ |
| PubMedID: 26779719 |
| Title : Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain - Burston_2016_Br.J.Pharmacol_173_3134 |
| Author(s) : Burston JJ , Mapp PI , Sarmad S , Barrett DA , Niphakis MJ , Cravatt BF , Walsh DA , Chapman V |
| Ref : British Journal of Pharmacology , 173 :3134 , 2016 |
| Abstract : |
| PubMedSearch : Burston_2016_Br.J.Pharmacol_173_3134 |
| PubMedID: 27501482 |
| Title : Just add water: cannabinoid discrimination in a water T-maze with FAAH(-\/-) and FAAH(+\/+) mice - Wiley_2016_Behav.Pharmacol_27_479 |
| Author(s) : Wiley JL , Lefever TW , Pulley NS , Marusich JA , Cravatt BF , Lichtman AH |
| Ref : Behav Pharmacol , 27 :479 , 2016 |
| Abstract : |
| PubMedSearch : Wiley_2016_Behav.Pharmacol_27_479 |
| PubMedID: 27385208 |
| Title : AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs - Parsons_2016_Nat.Chem.Biol_12_367 |
| Author(s) : Parsons WH , Kolar MJ , Kamat SS , Cognetta AB, 3rd , Hulce JJ , Saez E , Kahn BB , Saghatelian A , Cravatt BF |
| Ref : Nat Chemical Biology , 12 :367 , 2016 |
| Abstract : |
| PubMedSearch : Parsons_2016_Nat.Chem.Biol_12_367 |
| PubMedID: 27018888 |
| Title : Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain - Wilkerson_2016_Br.J.Pharmacol_173_1678 |
| Author(s) : Wilkerson JL , Ghosh S , Bagdas D , Mason BL , Crowe MS , Hsu KL , Wise LE , Kinsey SG , Damaj MI , Cravatt BF , Lichtman AH |
| Ref : British Journal of Pharmacology , 173 :1678 , 2016 |
| Abstract : |
| PubMedSearch : Wilkerson_2016_Br.J.Pharmacol_173_1678 |
| PubMedID: 26915789 |
| Title : Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats - Wills_2016_Neuropsychopharmacology_41_1865 |
| Author(s) : Wills KL , Petrie GN , Millett G , Limebeer CL , Rock EM , Niphakis MJ , Cravatt BF , Parker LA |
| Ref : Neuropsychopharmacology , 41 :1865 , 2016 |
| Abstract : |
| PubMedSearch : Wills_2016_Neuropsychopharmacology_41_1865 |
| PubMedID: 26647976 |
| Title : Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex - Sticht_2016_Neuropharmacol_102_92 |
| Author(s) : Sticht MA , Limebeer CL , Rafla BR , Abdullah RA , Poklis JL , Ho W , Niphakis MJ , Cravatt BF , Sharkey KA , Lichtman AH , Parker LA |
| Ref : Neuropharmacology , 102 :92 , 2016 |
| Abstract : |
| PubMedSearch : Sticht_2016_Neuropharmacol_102_92 |
| PubMedID: 26541329 |
| Title : Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase - Liu_2016_Sci.Rep_6_35829 |
| Author(s) : Liu X , Chen Y , Vickstrom CR , Li Y , Viader A , Cravatt BF , Liu QS |
| Ref : Sci Rep , 6 :35829 , 2016 |
| Abstract : |
| PubMedSearch : Liu_2016_Sci.Rep_6_35829 |
| PubMedID: 27775008 |
| Title : An in vivo multiplexed small-molecule screening platform - Gruner_2016_Nat.Methods_13_883 |
| Author(s) : Gruner BM , Schulze CJ , Yang D , Ogasawara D , Dix MM , Rogers ZN , Chuang CH , McFarland CD , Chiou SH , Brown JM , Cravatt BF , Bogyo M , Winslow MM |
| Ref : Nat Methods , 13 :883 , 2016 |
| Abstract : |
| PubMedSearch : Gruner_2016_Nat.Methods_13_883 |
| PubMedID: 27617390 |
| Title : Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase - Kolar_2016_Biochemistry_55_4636 |
| Author(s) : Kolar MJ , Kamat SS , Parsons WH , Homan EA , Maher T , Peroni OD , Syed I , Fjeld K , Molven A , Kahn BB , Cravatt BF , Saghatelian A |
| Ref : Biochemistry , 55 :4636 , 2016 |
| Abstract : |
| PubMedSearch : Kolar_2016_Biochemistry_55_4636 |
| PubMedID: 27509211 |
| Gene_locus related to this paper: human-CEL |
| Title : Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice - Ghosh_2015_J.Pharmacol.Exp.Ther_354_111 |
| Author(s) : Ghosh S , Kinsey SG , Liu QS , Hruba L , McMahon LR , Grim TW , Merritt CR , Wise LE , Abdullah RA , Selley DE , Sim-Selley LJ , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 354 :111 , 2015 |
| Abstract : |
| PubMedSearch : Ghosh_2015_J.Pharmacol.Exp.Ther_354_111 |
| PubMedID: 25998048 |
| Title : Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus - Parker_2015_Psychopharmacology.(Berl)_232_583 |
| Author(s) : Parker LA , Niphakis MJ , Downey R , Limebeer CL , Rock EM , Sticht MA , Morris H , Abdullah RA , Lichtman AH , Cravatt BF |
| Ref : Psychopharmacology (Berl) , 232 :583 , 2015 |
| Abstract : |
| PubMedSearch : Parker_2015_Psychopharmacology.(Berl)_232_583 |
| PubMedID: 25085768 |
| Gene_locus related to this paper: human-MGLL |
| Title : Combining cross-metathesis and activity-based protein profiling: New beta-lactone motifs for targeting serine hydrolases - Camara_2015_Bioorg.Med.Chem.Lett_25_317 |
| Author(s) : Camara K , Kamat SS , Lasota CC , Cravatt BF , Howell AR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :317 , 2015 |
| Abstract : |
| PubMedSearch : Camara_2015_Bioorg.Med.Chem.Lett_25_317 |
| PubMedID: 25541002 |
| Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164 |
| Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF |
| Ref : Nat Chemical Biology , 11 :164 , 2015 |
| Abstract : |
| PubMedSearch : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedID: 25580854 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a |
| Title : Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons - Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| Author(s) : Baggelaar MP , Chameau PJ , Kantae V , Hummel J , Hsu KL , Janssen F , van der Wel T , Soethoudt M , Deng H , den Dulk H , Allara M , Florea BI , Di Marzo V , Wadman WJ , Kruse CG , Overkleeft HS , Hankemeier T , Werkman TR , Cravatt BF , van der Stelt M |
| Ref : Journal of the American Chemical Society , 137 :8851 , 2015 |
| Abstract : |
| PubMedSearch : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| PubMedID: 26083464 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system - Lee_2015_Biochemistry_54_2539 |
| Author(s) : Lee HC , Simon GM , Cravatt BF |
| Ref : Biochemistry , 54 :2539 , 2015 |
| Abstract : |
| PubMedSearch : Lee_2015_Biochemistry_54_2539 |
| PubMedID: 25853435 |
| Gene_locus related to this paper: human-ABHD4 |
| Title : Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice - Gamage_2015_Drug.Alcohol.Depend_146_7 |
| Author(s) : Gamage TF , Ignatowska-Jankowska BM , Muldoon PP , Cravatt BF , Damaj MI , Lichtman AH |
| Ref : Drug Alcohol Depend , 146 :7 , 2015 |
| Abstract : |
| PubMedSearch : Gamage_2015_Drug.Alcohol.Depend_146_7 |
| PubMedID: 25479915 |
| Title : Delta9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice - Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| Author(s) : Wiebelhaus JM , Grim TW , Owens RA , Lazenka MF , Sim-Selley LJ , Abdullah RA , Niphakis MJ , Vann RE , Cravatt BF , Wiley JL , Negus SS , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 352 :195 , 2015 |
| Abstract : |
| PubMedSearch : Wiebelhaus_2015_J.Pharmacol.Exp.Ther_352_195 |
| PubMedID: 25398241 |
| Title : Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Delta9-tetrahydrocannabinol in mice - Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| Author(s) : Hruba L , Seillier A , Zaki A , Cravatt BF , Lichtman AH , Giuffrida A , McMahon LR |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 353 :261 , 2015 |
| Abstract : |
| PubMedSearch : Hruba_2015_J.Pharmacol.Exp.Ther_353_261 |
| PubMedID: 25711338 |
| Title : Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice - Ignatowska-Jankowska_2015_J.Pharmacol.Exp.Ther_353_424 |
| Author(s) : Ignatowska-Jankowska B , Wilkerson JL , Mustafa M , Abdullah R , Niphakis M , Wiley JL , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 353 :424 , 2015 |
| Abstract : |
| PubMedSearch : Ignatowska-Jankowska_2015_J.Pharmacol.Exp.Ther_353_424 |
| PubMedID: 25762694 |
| Title : Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases - Cognetta_2015_Chem.Biol_22_928 |
| Author(s) : Cognetta AB, 3rd , Niphakis MJ , Lee HC , Martini ML , Hulce JJ , Cravatt BF |
| Ref : Chemical Biology , 22 :928 , 2015 |
| Abstract : |
| PubMedSearch : Cognetta_2015_Chem.Biol_22_928 |
| PubMedID: 26120000 |
| Title : Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis - Zhao_2015_ACS.Chem.Biol_10_364 |
| Author(s) : Zhao N , Darby CM , Small J , Bachovchin DA , Jiang X , Burns-Huang KE , Botella H , Ehrt S , Boger DL , Anderson ED , Cravatt BF , Speers AE , Fernandez-Vega V , Hodder PS , Eberhart C , Rosen H , Spicer TP , Nathan CF |
| Ref : ACS Chemical Biology , 10 :364 , 2015 |
| Abstract : |
| PubMedSearch : Zhao_2015_ACS.Chem.Biol_10_364 |
| PubMedID: 25457457 |
| Title : Comprehensive Analysis of Structure-Activity Relationships of alpha-Ketoheterocycles as sn-1-Diacylglycerol Lipase alpha Inhibitors - Janssen_2015_J.Med.Chem_58_9742 |
| Author(s) : Janssen FJ , Baggelaar MP , Hummel JJ , Overkleeft HS , Cravatt BF , Boger DL , van der Stelt M |
| Ref : Journal of Medicinal Chemistry , 58 :9742 , 2015 |
| Abstract : |
| PubMedSearch : Janssen_2015_J.Med.Chem_58_9742 |
| PubMedID: 26584396 |
| Title : Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity - Zhang_2015_Hippocampus_25_16 |
| Author(s) : Zhang Z , Wang W , Zhong P , Liu SJ , Long JZ , Zhao L , Gao HQ , Cravatt BF , Liu QS |
| Ref : Hippocampus , 25 :16 , 2015 |
| Abstract : |
| PubMedSearch : Zhang_2015_Hippocampus_25_16 |
| PubMedID: 25131612 |
| Gene_locus related to this paper: human-MGLL |
| Title : Inhibition of monoacylglycerol lipase reduces nicotine withdrawal - Muldoon_2015_Br.J.Pharmacol_172_869 |
| Author(s) : Muldoon PP , Chen J , Harenza JL , Abdullah RA , Sim-Selley LJ , Cravatt BF , Miles MF , Chen X , Lichtman AH , Damaj MI |
| Ref : British Journal of Pharmacology , 172 :869 , 2015 |
| Abstract : |
| PubMedSearch : Muldoon_2015_Br.J.Pharmacol_172_869 |
| PubMedID: 25258021 |
| Gene_locus related to this paper: human-MGLL |
| Title : Monoacylglycerol Lipase Regulates Fever Response - Sanchez-Alavez_2015_PLoS.One_10_e0134437 |
| Author(s) : Sanchez-Alavez M , Nguyen W , Mori S , Moroncini G , Viader A , Nomura DK , Cravatt BF , Conti B |
| Ref : PLoS ONE , 10 :e0134437 , 2015 |
| Abstract : |
| PubMedSearch : Sanchez-Alavez_2015_PLoS.One_10_e0134437 |
| PubMedID: 26287872 |
| Title : Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice - Schlosburg_2014_J.Pharmacol.Exp.Ther_350_196 |
| Author(s) : Schlosburg JE , Kinsey SG , Ignatowska-Jankowska B , Ramesh D , Abdullah RA , Tao Q , Booker L , Long JZ , Selley DE , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 350 :196 , 2014 |
| Abstract : |
| PubMedSearch : Schlosburg_2014_J.Pharmacol.Exp.Ther_350_196 |
| PubMedID: 24849924 |
| Gene_locus related to this paper: human-MGLL |
| Title : In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects - Ignatowska-Jankowska_2014_Br.J.Pharmacol_171_1392 |
| Author(s) : Ignatowska-Jankowska BM , Ghosh S , Crowe MS , Kinsey SG , Niphakis MJ , Abdullah RA , Tao Q , ST ON , Walentiny DM , Wiley JL , Cravatt BF , Lichtman AH |
| Ref : British Journal of Pharmacology , 171 :1392 , 2014 |
| Abstract : |
| PubMedSearch : Ignatowska-Jankowska_2014_Br.J.Pharmacol_171_1392 |
| PubMedID: 23848221 |
| Gene_locus related to this paper: human-MGLL |
| Title : Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells - Manna_2014_J.Biol.Chem_289_33741 |
| Author(s) : Manna JD , Wepy JA , Hsu KL , Chang JW , Cravatt BF , Marnett LJ |
| Ref : Journal of Biological Chemistry , 289 :33741 , 2014 |
| Abstract : |
| PubMedSearch : Manna_2014_J.Biol.Chem_289_33741 |
| PubMedID: 25301951 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6\/2 Mice - Naydenov_2014_Neuron_83_361 |
| Author(s) : Naydenov AV , Horne EA , Cheah CS , Swinney K , Hsu KL , Cao JK , Marrs WR , Blankman JL , Tu S , Cherry AE , Fung S , Wen A , Li W , Saporito MS , Selley DE , Cravatt BF , Oakley JC , Stella N |
| Ref : Neuron , 83 :361 , 2014 |
| Abstract : |
| PubMedSearch : Naydenov_2014_Neuron_83_361 |
| PubMedID: 25033180 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation - Yun_2014_J.Biol.Chem_289_1491 |
| Author(s) : Yun B , Lee H , Ghosh M , Cravatt BF , Hsu KL , Bonventre JV , Ewing H , Gelb MH , Leslie CC |
| Ref : Journal of Biological Chemistry , 289 :1491 , 2014 |
| Abstract : |
| PubMedSearch : Yun_2014_J.Biol.Chem_289_1491 |
| PubMedID: 24297180 |
| Title : Endocannabinoids modulate cortical development by configuring Slit2\/Robo1 signalling - Alpar_2014_Nat.Commun_5_4421 |
| Author(s) : Alpar A , Tortoriello G , Calvigioni D , Niphakis MJ , Milenkovic I , Bakker J , Cameron GA , Hanics J , Morris CV , Fuzik J , Kovacs GG , Cravatt BF , Parnavelas JG , Andrews WD , Hurd YL , Keimpema E , Harkany T |
| Ref : Nat Commun , 5 :4421 , 2014 |
| Abstract : |
| PubMedSearch : Alpar_2014_Nat.Commun_5_4421 |
| PubMedID: 25030704 |
| Title : Molecular medicine and neurodegenerative diseases - |
| Author(s) : Chang CJ , Cravatt BF , Johnson DS , Lim MH |
| Ref : Chem Soc Rev , 43 :6668 , 2014 |
| PubMedID: 25105517 |
| Title : Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells - Kambe_2014_J.Am.Chem.Soc_136_10777 |
| Author(s) : Kambe T , Correia BE , Niphakis MJ , Cravatt BF |
| Ref : Journal of the American Chemical Society , 136 :10777 , 2014 |
| Abstract : |
| PubMedSearch : Kambe_2014_J.Am.Chem.Soc_136_10777 |
| PubMedID: 25045785 |
| Title : Enzyme inhibitor discovery by activity-based protein profiling - Niphakis_2014_Annu.Rev.Biochem_83_341 |
| Author(s) : Niphakis MJ , Cravatt BF |
| Ref : Annual Review of Biochemistry , 83 :341 , 2014 |
| Abstract : |
| PubMedSearch : Niphakis_2014_Annu.Rev.Biochem_83_341 |
| PubMedID: 24905785 |
| Title : Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling - Zhong_2014_Neuropsychopharmacology_39_1763 |
| Author(s) : Zhong P , Wang W , Pan B , Liu X , Zhang Z , Long JZ , Zhang HT , Cravatt BF , Liu QS |
| Ref : Neuropsychopharmacology , 39 :1763 , 2014 |
| Abstract : |
| PubMedSearch : Zhong_2014_Neuropsychopharmacology_39_1763 |
| PubMedID: 24476943 |
| Title : Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone - Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| Author(s) : Lajkiewicz NJ , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF , Porco JA, Jr. |
| Ref : Journal of the American Chemical Society , 136 :2659 , 2014 |
| Abstract : |
| PubMedSearch : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| PubMedID: 24447064 |
| Gene_locus related to this paper: human-ABHD10 , human-ACOT1 , human-ACOT2 , human-CTSA , human-SCPEP1 , mouse-abhda |
| Title : ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue - Galmozzi_2014_Cell.Rep_9_1584 |
| Author(s) : Galmozzi A , Sonne SB , Altshuler-Keylin S , Hasegawa Y , Shinoda K , Luijten IH , Chang JW , Sharp LZ , Cravatt BF , Saez E , Kajimura S |
| Ref : Cell Rep , 9 :1584 , 2014 |
| Abstract : |
| PubMedSearch : Galmozzi_2014_Cell.Rep_9_1584 |
| PubMedID: 25466254 |
| Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113 |
| Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E |
| Ref : Nat Chemical Biology , 10 :113 , 2014 |
| Abstract : |
| PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113 |
| PubMedID: 24362705 |
| Gene_locus related to this paper: human-CES3 , mouse-Ces1d |
| Title : Application of activity-based protein profiling to study enzyme function in adipocytes - Galmozzi_2014_Methods.Enzymol_538_151 |
| Author(s) : Galmozzi A , Dominguez E , Cravatt BF , Saez E |
| Ref : Methods Enzymol , 538 :151 , 2014 |
| Abstract : |
| PubMedSearch : Galmozzi_2014_Methods.Enzymol_538_151 |
| PubMedID: 24529438 |
| Title : Design of activated serine-containing catalytic triads with atomic-level accuracy - Rajagopalan_2014_Nat.Chem.Biol_10_386 |
| Author(s) : Rajagopalan S , Wang C , Yu K , Kuzin AP , Richter F , Lew S , Miklos AE , Matthews ML , Seetharaman J , Su M , Hunt JF , Cravatt BF , Baker D |
| Ref : Nat Chemical Biology , 10 :386 , 2014 |
| Abstract : |
| PubMedSearch : Rajagopalan_2014_Nat.Chem.Biol_10_386 |
| PubMedID: 24705591 |
| Title : Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) - Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| Author(s) : Nagano JM , Hsu KL , Whitby LR , Niphakis MJ , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder P , Srinivasan P , Gonzalez TD , Rosen H , Bahnson BJ , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :839 , 2013 |
| Abstract : |
| PubMedSearch : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| PubMedID: 23260346 |
| Title : Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice - Ramesh_2013_Neuropsychopharmacology_38_1039 |
| Author(s) : Ramesh D , Gamage TF , Vanuytsel T , Owens RA , Abdullah RA , Niphakis MJ , Shea-Donohue T , Cravatt BF , Lichtman AH |
| Ref : Neuropsychopharmacology , 38 :1039 , 2013 |
| Abstract : |
| PubMedSearch : Ramesh_2013_Neuropsychopharmacology_38_1039 |
| PubMedID: 23303065 |
| Gene_locus related to this paper: human-MGLL |
| Title : Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice - Cao_2013_Gastroenterology_144_808 |
| Author(s) : Cao Z , Mulvihill MM , Mukhopadhyay P , Xu H , Erdelyi K , Hao E , Holovac E , Hasko G , Cravatt BF , Nomura DK , Pacher P |
| Ref : Gastroenterology , 144 :808 , 2013 |
| Abstract : |
| PubMedSearch : Cao_2013_Gastroenterology_144_808 |
| PubMedID: 23295443 |
| Gene_locus related to this paper: human-MGLL |
| Title : Chemical probes of endocannabinoid metabolism - Blankman_2013_Pharmacol.Rev_65_849 |
| Author(s) : Blankman JL , Cravatt BF |
| Ref : Pharmacol Rev , 65 :849 , 2013 |
| Abstract : |
| PubMedSearch : Blankman_2013_Pharmacol.Rev_65_849 |
| PubMedID: 23512546 |
| Gene_locus related to this paper: human-MGLL |
| Title : The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model - Ghosh_2013_Life.Sci_92_498 |
| Author(s) : Ghosh S , Wise LE , Chen Y , Gujjar R , Mahadevan A , Cravatt BF , Lichtman AH |
| Ref : Life Sciences , 92 :498 , 2013 |
| Abstract : |
| PubMedSearch : Ghosh_2013_Life.Sci_92_498 |
| PubMedID: 22749865 |
| Gene_locus related to this paper: human-MGLL |
| Title : Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects - Kinsey_2013_J.Pharmacol.Exp.Ther_345_492 |
| Author(s) : Kinsey SG , Wise LE , Ramesh D , Abdullah R , Selley DE , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 345 :492 , 2013 |
| Abstract : |
| PubMedSearch : Kinsey_2013_J.Pharmacol.Exp.Ther_345_492 |
| PubMedID: 23412396 |
| Gene_locus related to this paper: human-MGLL |
| Title : The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome - Thomas_2013_Cell.Rep_5_508 |
| Author(s) : Thomas G , Betters JL , Lord CC , Brown AL , Marshall S , Ferguson D , Sawyer J , Davis MA , Melchior JT , Blume LC , Howlett AC , Ivanova PT , Milne SB , Myers DS , Mrak I , Leber V , Heier C , Taschler U , Blankman JL , Cravatt BF , Lee RG , Crooke RM , Graham MJ , Zimmermann R , Brown HA , Brown JM |
| Ref : Cell Rep , 5 :508 , 2013 |
| Abstract : |
| PubMedSearch : Thomas_2013_Cell.Rep_5_508 |
| PubMedID: 24095738 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) - Adibekian_2013_Probe.Report__4 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2013 |
| Abstract : |
| PubMedSearch : Adibekian_2013_Probe.Report__4 |
| PubMedID: 24624468 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects - Bisogno_2013_Br.J.Pharmacol_169_784 |
| Author(s) : Bisogno T , Mahadevan A , Coccurello R , Chang JW , Allara M , Chen Y , Giacovazzo G , Lichtman A , Cravatt BF , Moles A , Di Marzo V |
| Ref : British Journal of Pharmacology , 169 :784 , 2013 |
| Abstract : |
| PubMedSearch : Bisogno_2013_Br.J.Pharmacol_169_784 |
| PubMedID: 23072382 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Two Novel Mutations in ABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects - Chen_2013_Hum.Mutat_34_1672 |
| Author(s) : Chen DH , Naydenov A , Blankman JL , Mefford HC , Davis M , Sul Y , Barloon AS , Bonkowski E , Wolff J , Matsushita M , Smith C , Cravatt BF , Mackie K , Raskind WH , Stella N , Bird TD |
| Ref : Hum Mutat , 34 :1672 , 2013 |
| Abstract : |
| PubMedSearch : Chen_2013_Hum.Mutat_34_1672 |
| PubMedID: 24027063 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC - Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500 |
| Author(s) : Blankman JL , Long JZ , Trauger SA , Siuzdak G , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 110 :1500 , 2013 |
| Abstract : |
| PubMedSearch : Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500 |
| PubMedID: 23297193 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257 |
| Author(s) : Hsu KL , Tsuboi K , Whitby LR , Speers AE , Pugh H , Inloes J , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8257 , 2013 |
| Abstract : |
| PubMedSearch : Hsu_2013_J.Med.Chem_56_8257 |
| PubMedID: 24152245 |
| Gene_locus related to this paper: human-DAGLB |
| Title : Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation - Holly_2013_Chem.Biol_20_1125 |
| Author(s) : Holly SP , Chang JW , Li W , Niessen S , Phillips RM , Piatt R , Black JL , Smith MC , Boulaftali Y , Weyrich AS , Bergmeier W , Cravatt BF , Parise LV |
| Ref : Chemical Biology , 20 :1125 , 2013 |
| Abstract : |
| PubMedSearch : Holly_2013_Chem.Biol_20_1125 |
| PubMedID: 23993462 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition - Chang_2013_ACS.Chem.Biol_8_1590 |
| Author(s) : Chang JW , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF |
| Ref : ACS Chemical Biology , 8 :1590 , 2013 |
| Abstract : |
| PubMedSearch : Chang_2013_ACS.Chem.Biol_8_1590 |
| PubMedID: 23701408 |
| Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1) - Adibekian_2013_Probe.Report__3 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2013 |
| Abstract : |
| PubMedSearch : Adibekian_2013_Probe.Report__3 |
| PubMedID: 24624465 |
| Title : Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells - Hulce_2013_Nat.Methods_10_259 |
| Author(s) : Hulce JJ , Cognetta AB, 3rd , Niphakis MJ , Tully SE , Cravatt BF |
| Ref : Nat Methods , 10 :259 , 2013 |
| Abstract : |
| PubMedSearch : Hulce_2013_Nat.Methods_10_259 |
| PubMedID: 23396283 |
| Title : Diced electrophoresis gel assay for screening enzymes with specified activities - Komatsu_2013_J.Am.Chem.Soc_135_6002 |
| Author(s) : Komatsu T , Hanaoka K , Adibekian A , Yoshioka K , Terai T , Ueno T , Kawaguchi M , Cravatt BF , Nagano T |
| Ref : Journal of the American Chemical Society , 135 :6002 , 2013 |
| Abstract : |
| PubMedSearch : Komatsu_2013_J.Am.Chem.Soc_135_6002 |
| PubMedID: 23581642 |
| Title : Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha\/beta-hydrolase domain containing 6 (ABHD6) - Hsu_2013_J.Med.Chem_56_8270 |
| Author(s) : Hsu KL , Tsuboi K , Chang JW , Whitby LR , Speers AE , Pugh H , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8270 , 2013 |
| Abstract : |
| PubMedSearch : Hsu_2013_J.Med.Chem_56_8270 |
| PubMedID: 24152295 |
| Title : Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors - Niphakis_2013_ACS.Chem.Neurosci_4_1322 |
| Author(s) : Niphakis MJ , Cognetta AB, 3rd , Chang JW , Buczynski MW , Parsons LH , Byrne F , Burston JJ , Chapman V , Cravatt BF |
| Ref : ACS Chem Neurosci , 4 :1322 , 2013 |
| Abstract : |
| PubMedSearch : Niphakis_2013_ACS.Chem.Neurosci_4_1322 |
| PubMedID: 23731016 |
| Gene_locus related to this paper: human-MGLL |
| Title : O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors - Niphakis_2012_ACS.Chem.Neurosci_3_418 |
| Author(s) : Niphakis MJ , Johnson DS , Ballard TE , Stiff C , Cravatt BF |
| Ref : ACS Chem Neurosci , 3 :418 , 2012 |
| Abstract : |
| PubMedSearch : Niphakis_2012_ACS.Chem.Neurosci_3_418 |
| PubMedID: 22860211 |
| Gene_locus related to this paper: human-MGLL |
| Title : Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates - Chang_2012_Chem.Biol_19_579 |
| Author(s) : Chang JW , Niphakis MJ , Lum KM , Cognetta AB, 3rd , Wang C , Matthews ML , Niessen S , Buczynski MW , Parsons LH , Cravatt BF |
| Ref : Chemical Biology , 19 :579 , 2012 |
| Abstract : |
| PubMedSearch : Chang_2012_Chem.Biol_19_579 |
| PubMedID: 22542104 |
| Gene_locus related to this paper: human-MGLL |
| Title : Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study - Wiskerke_2012_ACS.Chem.Neurosci_3_407 |
| Author(s) : Wiskerke J , Irimia C , Cravatt BF , De Vries TJ , Schoffelmeer AN , Pattij T , Parsons LH |
| Ref : ACS Chem Neurosci , 3 :407 , 2012 |
| Abstract : |
| PubMedSearch : Wiskerke_2012_ACS.Chem.Neurosci_3_407 |
| PubMedID: 22860210 |
| Title : Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) - Hsu_2012_Probe.Report__ |
| Author(s) : Hsu KL , Tsuboi K , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2012 |
| Abstract : |
| PubMedSearch : Hsu_2012_Probe.Report__ |
| PubMedID: 23658950 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Global profiling of dynamic protein palmitoylation - Martin_2012_Nat.Methods_9_84 |
| Author(s) : Martin BR , Wang C , Adibekian A , Tully SE , Cravatt BF |
| Ref : Nat Methods , 9 :84 , 2012 |
| Abstract : |
| PubMedSearch : Martin_2012_Nat.Methods_9_84 |
| PubMedID: 22056678 |
| Title : Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP - Kaschani_2012_Bioorg.Med.Chem_20_597 |
| Author(s) : Kaschani F , Nickel S , Pandey B , Cravatt BF , Kaiser M , van der Hoorn RA |
| Ref : Bioorganic & Medicinal Chemistry , 20 :597 , 2012 |
| Abstract : |
| PubMedSearch : Kaschani_2012_Bioorg.Med.Chem_20_597 |
| PubMedID: 21764588 |
| Title : DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses - Hsu_2012_Nat.Chem.Biol_8_999 |
| Author(s) : Hsu KL , Tsuboi K , Adibekian A , Pugh H , Masuda K , Cravatt BF |
| Ref : Nat Chemical Biology , 8 :999 , 2012 |
| Abstract : |
| PubMedSearch : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedID: 23103940 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9 - Liu_2012_Chembiochem_13_2082 |
| Author(s) : Liu X , Dix M , Speers AE , Bachovchin DA , Zuhl AM , Cravatt BF , Kodadek TJ |
| Ref : Chembiochem , 13 :2082 , 2012 |
| Abstract : |
| PubMedSearch : Liu_2012_Chembiochem_13_2082 |
| PubMedID: 22907802 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition - Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| Author(s) : Zuhl AM , Mohr JT , Bachovchin DA , Niessen S , Hsu KL , Berlin JM , Dochnahl M , Lopez-Alberca MP , Fu GC , Cravatt BF |
| Ref : J Am Chem Soc , 134 :5068 , 2012 |
| Abstract : |
| PubMedSearch : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| PubMedID: 22400490 |
| Gene_locus related to this paper: human-ABHD10 |
| Title : Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis - Seeliger_2012_J.Biol.Chem_287_7990 |
| Author(s) : Seeliger JC , Holsclaw CM , Schelle MW , Botyanszki Z , Gilmore SA , Tully SE , Niederweis M , Cravatt BF , Leary JA , Bertozzi CR |
| Ref : Journal of Biological Chemistry , 287 :7990 , 2012 |
| Abstract : |
| PubMedSearch : Seeliger_2012_J.Biol.Chem_287_7990 |
| PubMedID: 22194604 |
| Gene_locus related to this paper: myctu-Rv3822 |
| Title : An activity-based imaging probe for the integral membrane hydrolase KIAA1363 - |
| Author(s) : Chang JW , Moellering RE , Cravatt BF |
| Ref : Angew Chem Int Ed Engl , 51 :966 , 2012 |
| PubMedID: 22162147 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : The pharmacological landscape and therapeutic potential of serine hydrolases - Bachovchin_2012_Nat.Rev.Drug.Discov_11_52 |
| Author(s) : Bachovchin DA , Cravatt BF |
| Ref : Nat Rev Drug Discov , 11 :52 , 2012 |
| Abstract : |
| PubMedSearch : Bachovchin_2012_Nat.Rev.Drug.Discov_11_52 |
| PubMedID: 22212679 |
| Title : Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes - Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder PS , Rosen H , Cravatt BF |
| Ref : J Am Chem Soc , 134 :10345 , 2012 |
| Abstract : |
| PubMedSearch : Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| PubMedID: 22690931 |
| Title : Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats - Sticht_2012_Br.J.Pharmacol_165_2425 |
| Author(s) : Sticht MA , Long JZ , Rock EM , Limebeer CL , Mechoulam R , Cravatt BF , Parker LA |
| Ref : British Journal of Pharmacology , 165 :2425 , 2012 |
| Abstract : |
| PubMedSearch : Sticht_2012_Br.J.Pharmacol_165_2425 |
| PubMedID: 21470205 |
| Title : Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice - Wise_2012_ACS.Chem.Neurosci_3_369 |
| Author(s) : Wise LE , Long KA , Abdullah RA , Long JZ , Cravatt BF , Lichtman AH |
| Ref : ACS Chem Neurosci , 3 :369 , 2012 |
| Abstract : |
| PubMedSearch : Wise_2012_ACS.Chem.Neurosci_3_369 |
| PubMedID: 22860205 |
| Gene_locus related to this paper: human-MGLL |
| Title : Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) - Adibekian_2011_Probe.Report__2 |
| Author(s) : Adibekian A , Hsu KL , Speers AE , Monillas ES , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Bahnson BJ , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2011 |
| Abstract : |
| PubMedSearch : Adibekian_2011_Probe.Report__2 |
| PubMedID: 23658960 |
| Title : The metabolic serine hydrolases and their functions in mammalian physiology and disease - |
| Author(s) : Long JZ , Cravatt BF |
| Ref : Chem Rev , 111 :6022 , 2011 |
| PubMedID: 21696217 |
| Title : Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) - Adibekian_2011_Probe.Report__5 |
| Author(s) : Adibekian A , Martin BR , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2011 |
| Abstract : |
| PubMedSearch : Adibekian_2011_Probe.Report__5 |
| PubMedID: 23658947 |
| Title : Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors - Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811 |
| Author(s) : Bachovchin DA , Mohr JT , Speers AE , Wang C , Berlin JM , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Schurer SC , Nomura DK , Rosen H , Fu GC , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 108 :6811 , 2011 |
| Abstract : |
| PubMedSearch : Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811 |
| PubMedID: 21398589 |
| Gene_locus related to this paper: human-PPME1 |
| Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665 |
| Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A |
| Ref : Journal of the American Chemical Society , 133 :11665 , 2011 |
| Abstract : |
| PubMedSearch : Lone_2011_J.Am.Chem.Soc_133_11665 |
| PubMedID: 21692504 |
| Gene_locus related to this paper: human-PREPL |
| Title : Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice - Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| Author(s) : Kinsey SG , Nomura DK , O'Neal ST , Long JZ , Mahadevan A , Cravatt BF , Grider JR , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 338 :795 , 2011 |
| Abstract : |
| PubMedSearch : Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| PubMedID: 21659471 |
| Title : Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice - Pan_2011_J.Neurosci_31_13420 |
| Author(s) : Pan B , Wang W , Zhong P , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal of Neuroscience , 31 :13420 , 2011 |
| Abstract : |
| PubMedSearch : Pan_2011_J.Neurosci_31_13420 |
| PubMedID: 21940435 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids - Long_2011_Nat.Chem.Biol_7_763 |
| Author(s) : Long JZ , Cisar JS , Milliken D , Niessen S , Wang C , Trauger SA , Siuzdak G , Cravatt BF |
| Ref : Nat Chemical Biology , 7 :763 , 2011 |
| Abstract : |
| PubMedSearch : Long_2011_Nat.Chem.Biol_7_763 |
| PubMedID: 21926997 |
| Gene_locus related to this paper: human-ABHD3 , mouse-abhd3 |
| Title : Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum - Zhong_2011_J.Physiol_589_4847 |
| Author(s) : Zhong P , Pan B , Gao XP , Blankman JL , Cravatt BF , Liu QS |
| Ref : Journal de Physiologie , 589 :4847 , 2011 |
| Abstract : |
| PubMedSearch : Zhong_2011_J.Physiol_589_4847 |
| PubMedID: 21911610 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation - Straiker_2011_Br.J.Pharmacol_164_1672 |
| Author(s) : Straiker A , Wager-Miller J , Hu SS , Blankman JL , Cravatt BF , Mackie K |
| Ref : British Journal of Pharmacology , 164 :1672 , 2011 |
| Abstract : |
| PubMedSearch : Straiker_2011_Br.J.Pharmacol_164_1672 |
| PubMedID: 21564090 |
| Title : Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay - Kinsey_2011_Pharmacol.Biochem.Behav_98_21 |
| Author(s) : Kinsey SG , O'Neal ST , Long JZ , Cravatt BF , Lichtman AH |
| Ref : Pharmacol Biochem Behav , 98 :21 , 2011 |
| Abstract : |
| PubMedSearch : Kinsey_2011_Pharmacol.Biochem.Behav_98_21 |
| PubMedID: 21145341 |
| Title : A potent and selective inhibitor of KIAA1363\/AADACL1 that impairs prostate cancer pathogenesis - Chang_2011_Chem.Biol_18_476 |
| Author(s) : Chang JW , Nomura DK , Cravatt BF |
| Ref : Chemical Biology , 18 :476 , 2011 |
| Abstract : |
| PubMedSearch : Chang_2011_Chem.Biol_18_476 |
| PubMedID: 21513884 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor - Johnson_2011_ACS.Med.Chem.Lett_2_91 |
| Author(s) : Johnson DS , Stiff C , Lazerwith SE , Kesten SR , Fay LK , Morris M , Beidler D , Liimatta MB , Smith SE , Dudley DT , Sadagopan N , Bhattachar SN , Kesten SJ , Nomanbhoy TK , Cravatt BF , Ahn K |
| Ref : ACS Med Chem Lett , 2 :91 , 2011 |
| Abstract : |
| PubMedSearch : Johnson_2011_ACS.Med.Chem.Lett_2_91 |
| PubMedID: 21666860 |
| Title : Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation - Nomura_2011_Science_334_809 |
| Author(s) : Nomura DK , Morrison BE , Blankman JL , Long JZ , Kinsey SG , Marcondes MC , Ward AM , Hahn YK , Lichtman AH , Conti B , Cravatt BF |
| Ref : Science , 334 :809 , 2011 |
| Abstract : |
| PubMedSearch : Nomura_2011_Science_334_809 |
| PubMedID: 22021672 |
| Title : Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice - Ramesh_2011_J.Pharmacol.Exp.Ther_339_173 |
| Author(s) : Ramesh D , Ross GR , Schlosburg JE , Owens RA , Abdullah RA , Kinsey SG , Long JZ , Nomura DK , Sim-Selley LJ , Cravatt BF , Akbarali HI , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 339 :173 , 2011 |
| Abstract : |
| PubMedSearch : Ramesh_2011_J.Pharmacol.Exp.Ther_339_173 |
| PubMedID: 21719468 |
| Title : Optimization and characterization of a triazole urea inhibitor for alpha\/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1\/LYPLA2 dual inhibitor ML211 - Adibekian_2011_Probe.Report__1 |
| Author(s) : Adibekian A , Hsu KL , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2011 |
| Abstract : |
| PubMedSearch : Adibekian_2011_Probe.Report__1 |
| PubMedID: 23658953 |
| Title : Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors - Adibekian_2011_Nat.Chem.Biol_7_469 |
| Author(s) : Adibekian A , Martin BR , Wang C , Hsu KL , Bachovchin DA , Niessen S , Hoover H , Cravatt BF |
| Ref : Nat Chemical Biology , 7 :469 , 2011 |
| Abstract : |
| PubMedSearch : Adibekian_2011_Nat.Chem.Biol_7_469 |
| PubMedID: 21572424 |
| Title : Probe Report for PME-1 Inhibitors - Bachovchin_2010_Probe.Report__2 |
| Author(s) : Bachovchin DA , Speers AE , Zuhl AM , Brown SJ , Cravatt BF , Fernandez V , Spicer T , Mercer BA , Ferguson J , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Probe.Report__2 |
| PubMedID: 21433379 |
| Title : Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| Author(s) : Bachovchin DA , Ji T , Li W , Simon GM , Blankman JL , Adibekian A , Hoover H , Niessen S , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 107 :20941 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| PubMedID: 21084632 |
| Title : The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors - Marrs_2010_Nat.Neurosci_13_951 |
| Author(s) : Marrs WR , Blankman JL , Horne EA , Thomazeau A , Lin YH , Coy J , Bodor AL , Muccioli GG , Hu SS , Woodruff G , Fung S , Lafourcade M , Alexander JP , Long JZ , Li W , Xu C , Moller T , Mackie K , Manzoni OJ , Cravatt BF , Stella N |
| Ref : Nat Neurosci , 13 :951 , 2010 |
| Abstract : |
| PubMedSearch : Marrs_2010_Nat.Neurosci_13_951 |
| PubMedID: 20657592 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis - Nomura_2010_Cell_140_49 |
| Author(s) : Nomura DK , Long JZ , Niessen S , Hoover HS , Ng SW , Cravatt BF |
| Ref : Cell , 140 :49 , 2010 |
| Abstract : |
| PubMedSearch : Nomura_2010_Cell_140_49 |
| PubMedID: 20079333 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Activity-based protein profiling for biochemical pathway discovery in cancer - Nomura_2010_Nat.Rev.Cancer_10_630 |
| Author(s) : Nomura DK , Dix MM , Cravatt BF |
| Ref : Nat Rev Cancer , 10 :630 , 2010 |
| Abstract : |
| PubMedSearch : Nomura_2010_Nat.Rev.Cancer_10_630 |
| PubMedID: 20703252 |
| Title : RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia - Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189 |
| Author(s) : Shields DJ , Niessen S , Murphy EA , Mielgo A , Desgrosellier JS , Lau SK , Barnes LA , Lesperance J , Bouvet M , Tarin D , Cravatt BF , Cheresh DA |
| Ref : Proc Natl Acad Sci U S A , 107 :2189 , 2010 |
| Abstract : |
| PubMedSearch : Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189 |
| PubMedID: 20080647 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) - Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| Author(s) : Bachovchin DA , Wolfe MR , Masuda K , Brown SJ , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2254 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| PubMedID: 20207142 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Probe Report for RBBP9 Inhibitors - Probe 2 - Bachovchin_2010_Probe.Report.1__ |
| Author(s) : Bachovchin DA , Speers AE , Brown SJ , Cravatt BF , Spicer T , Mercer BA , Ferguson J , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Probe.Report.1__ |
| PubMedID: 21433382 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Probe Report for RBBP9 Inhibitors - Probe 1 - Brown_2010_Probe.Report__ |
| Author(s) : Brown SJ , Bachovchin DA , Cravatt BF , Fernandez-Vega V , Spicer T , Mercer BA , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Brown_2010_Probe.Report__ |
| PubMedID: 21433353 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study - Simon_2010_J.Biol.Chem_285_11051 |
| Author(s) : Simon GM , Cravatt BF |
| Ref : Journal of Biological Chemistry , 285 :11051 , 2010 |
| Abstract : |
| PubMedSearch : Simon_2010_J.Biol.Chem_285_11051 |
| PubMedID: 20147750 |
| Title : Endocannabinoid overload - Lichtman_2010_Mol.Pharmacol_78_993 |
| Author(s) : Lichtman AH , Blankman JL , Cravatt BF |
| Ref : Molecular Pharmacology , 78 :993 , 2010 |
| Abstract : |
| PubMedSearch : Lichtman_2010_Mol.Pharmacol_78_993 |
| PubMedID: 20952498 |
| Title : Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms - Kinsey_2010_J.Pain_11_1420 |
| Author(s) : Kinsey SG , Long JZ , Cravatt BF , Lichtman AH |
| Ref : J Pain , 11 :1420 , 2010 |
| Abstract : |
| PubMedSearch : Kinsey_2010_J.Pain_11_1420 |
| PubMedID: 20554481 |
| Title : Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system - Schlosburg_2010_Nat.Neurosci_13_1113 |
| Author(s) : Schlosburg JE , Blankman JL , Long JZ , Nomura DK , Pan B , Kinsey SG , Nguyen PT , Ramesh D , Booker L , Burston JJ , Thomas EA , Selley DE , Sim-Selley LJ , Liu QS , Lichtman AH , Cravatt BF |
| Ref : Nat Neurosci , 13 :1113 , 2010 |
| Abstract : |
| PubMedSearch : Schlosburg_2010_Nat.Neurosci_13_1113 |
| PubMedID: 20729846 |
| Title : Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases - Long_2010_J.Med.Chem_53_1830 |
| Author(s) : Long JZ , Jin X , Adibekian A , Li W , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 53 :1830 , 2010 |
| Abstract : |
| PubMedSearch : Long_2010_J.Med.Chem_53_1830 |
| PubMedID: 20099888 |
| Title : Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1) - Bachovchin_2010_Probe.Report__1 |
| Author(s) : Bachovchin DA , Speers AE , Brown SJ , Spicer TP , Fernandez V , Ferguson J , Mohr JT , Murphy J , Fu GC , Cravatt BF , Hodder PS , Rosen H |
| Ref : Probe Report , : , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Probe.Report__1 |
| PubMedID: 22834039 |
| Title : Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling - Pan_2009_J.Pharmacol.Exp.Ther_331_591 |
| Author(s) : Pan B , Wang W , Long JZ , Sun D , Hillard CJ , Cravatt BF , Liu QS |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :591 , 2009 |
| Abstract : |
| PubMedSearch : Pan_2009_J.Pharmacol.Exp.Ther_331_591 |
| PubMedID: 19666749 |
| Title : Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons - Straiker_2009_Mol.Pharmacol_76_1220 |
| Author(s) : Straiker A , Hu SS , Long JZ , Arnold A , Wager-Miller J , Cravatt BF , Mackie K |
| Ref : Molecular Pharmacology , 76 :1220 , 2009 |
| Abstract : |
| PubMedSearch : Straiker_2009_Mol.Pharmacol_76_1220 |
| PubMedID: 19767452 |
| Gene_locus related to this paper: human-MGLL |
| Title : Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects - Long_2009_Nat.Chem.Biol_5_37 |
| Author(s) : Long JZ , Li W , Booker L , Burston JJ , Kinsey SG , Schlosburg JE , Pavon FJ , Serrano AM , Selley DE , Parsons LH , Lichtman AH , Cravatt BF |
| Ref : Nat Chemical Biology , 5 :37 , 2009 |
| Abstract : |
| PubMedSearch : Long_2009_Nat.Chem.Biol_5_37 |
| PubMedID: 19029917 |
| Title : Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism - Long_2009_Chem.Biol_16_744 |
| Author(s) : Long JZ , Nomura DK , Cravatt BF |
| Ref : Chemical Biology , 16 :744 , 2009 |
| Abstract : |
| PubMedSearch : Long_2009_Chem.Biol_16_744 |
| PubMedID: 19635411 |
| Title : Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain - Kinsey_2009_J.Pharmacol.Exp.Ther_330_902 |
| Author(s) : Kinsey SG , Long JZ , O'Neal ST , Abdullah RA , Poklis JL , Boger DL , Cravatt BF , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 330 :902 , 2009 |
| Abstract : |
| PubMedSearch : Kinsey_2009_J.Pharmacol.Exp.Ther_330_902 |
| PubMedID: 19502530 |
| Title : Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice - Schlosburg_2009_AAPS.J_11_342 |
| Author(s) : Schlosburg JE , Carlson BL , Ramesh D , Abdullah RA , Long JZ , Cravatt BF , Lichtman AH |
| Ref : AAPS J , 11 :342 , 2009 |
| Abstract : |
| PubMedSearch : Schlosburg_2009_AAPS.J_11_342 |
| PubMedID: 19430909 |
| Title : Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes - Bachovchin_2009_Nat.Biotechnol_27_387 |
| Author(s) : Bachovchin DA , Brown SJ , Rosen H , Cravatt BF |
| Ref : Nat Biotechnol , 27 :387 , 2009 |
| Abstract : |
| PubMedSearch : Bachovchin_2009_Nat.Biotechnol_27_387 |
| PubMedID: 19329999 |
| Gene_locus related to this paper: human-ABHD11 |
| Title : Large-scale profiling of protein palmitoylation in mammalian cells - Martin_2009_Nat.Methods_6_135 |
| Author(s) : Martin BR , Cravatt BF |
| Ref : Nat Methods , 6 :135 , 2009 |
| Abstract : |
| PubMedSearch : Martin_2009_Nat.Methods_6_135 |
| PubMedID: 19137006 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana - Kaschani_2009_Mol.Cell.Proteomics_8_1082 |
| Author(s) : Kaschani F , Gu C , Niessen S , Hoover H , Cravatt BF , van der Hoorn RA |
| Ref : Mol Cell Proteomics , 8 :1082 , 2009 |
| Abstract : |
| PubMedSearch : Kaschani_2009_Mol.Cell.Proteomics_8_1082 |
| PubMedID: 19136719 |
| Title : Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo - Long_2009_Proc.Natl.Acad.Sci.U.S.A_106_20270 |
| Author(s) : Long JZ , Nomura DK , Vann RE , Walentiny DM , Booker L , Jin X , Burston JJ , Sim-Selley LJ , Lichtman AH , Wiley JL , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 106 :20270 , 2009 |
| Abstract : |
| PubMedSearch : Long_2009_Proc.Natl.Acad.Sci.U.S.A_106_20270 |
| PubMedID: 19918051 |
| Title : Activation of the endocannabinoid system by organophosphorus nerve agents - Nomura_2008_Nat.Chem.Biol_4_373 |
| Author(s) : Nomura DK , Blankman JL , Simon GM , Fujioka K , Issa RS , Ward AM , Cravatt BF , Casida JE |
| Ref : Nat Chemical Biology , 4 :373 , 2008 |
| Abstract : |
| PubMedSearch : Nomura_2008_Nat.Chem.Biol_4_373 |
| PubMedID: 18438404 |
| Title : Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain - Simon_2008_J.Biol.Chem_283_9341 |
| Author(s) : Simon GM , Cravatt BF |
| Ref : Journal of Biological Chemistry , 283 :9341 , 2008 |
| Abstract : |
| PubMedSearch : Simon_2008_J.Biol.Chem_283_9341 |
| PubMedID: 18227059 |
| Title : Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase - DeMartino_2008_Bioorg.Med.Chem.Lett_18_5842 |
| Author(s) : DeMartino JK , Garfunkle J , Hochstatter DG , Cravatt BF , Boger DL |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5842 , 2008 |
| Abstract : |
| PubMedSearch : DeMartino_2008_Bioorg.Med.Chem.Lett_18_5842 |
| PubMedID: 18639454 |
| Title : Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification - Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| Author(s) : Nomura DK , Fujioka K , Issa RS , Ward AM , Cravatt BF , Casida JE |
| Ref : Toxicol Appl Pharmacol , 228 :42 , 2008 |
| Abstract : |
| PubMedSearch : Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| PubMedID: 18164358 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling - Hoover_2008_Bioorg.Med.Chem.Lett_18_5838 |
| Author(s) : Hoover HS , Blankman JL , Niessen S , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5838 , 2008 |
| Abstract : |
| PubMedSearch : Hoover_2008_Bioorg.Med.Chem.Lett_18_5838 |
| PubMedID: 18657971 |
| Title : Evaluation of fatty acid amides in the carrageenan-induced paw edema model - Wise_2008_Neuropharmacol_54_181 |
| Author(s) : Wise LE , Cannavacciulo R , Cravatt BF , Martin BF , Lichtman AH |
| Ref : Neuropharmacology , 54 :181 , 2008 |
| Abstract : |
| PubMedSearch : Wise_2008_Neuropharmacol_54_181 |
| PubMedID: 17675189 |
| Title : A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases - |
| Author(s) : Li W , Blankman JL , Cravatt BF |
| Ref : Journal of the American Chemical Society , 129 :9594 , 2007 |
| PubMedID: 17629278 |
| Title : A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol - Blankman_2007_Chem.Biol_14_1347 |
| Author(s) : Blankman JL , Simon GM , Cravatt BF |
| Ref : Chemical Biology , 14 :1347 , 2007 |
| Abstract : |
| PubMedSearch : Blankman_2007_Chem.Biol_14_1347 |
| PubMedID: 18096503 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality - Naidu_2007_Psychopharmacology.(Berl)_192_61 |
| Author(s) : Naidu PS , Varvel SA , Ahn K , Cravatt BF , Martin BR , Lichtman AH |
| Ref : Psychopharmacology (Berl) , 192 :61 , 2007 |
| Abstract : |
| PubMedSearch : Naidu_2007_Psychopharmacology.(Berl)_192_61 |
| PubMedID: 17279376 |
| Title : Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors - Wise_2007_Eur.J.Pharmacol_557_44 |
| Author(s) : Wise LE , Shelton CC , Cravatt BF , Martin BR , Lichtman AH |
| Ref : European Journal of Pharmacology , 557 :44 , 2007 |
| Abstract : |
| PubMedSearch : Wise_2007_Eur.J.Pharmacol_557_44 |
| PubMedID: 17217945 |
| Title : The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases - Alexander_2006_J.Am.Chem.Soc_128_9699 |
| Author(s) : Alexander JP , Cravatt BF |
| Ref : Journal of the American Chemical Society , 128 :9699 , 2006 |
| Abstract : |
| PubMedSearch : Alexander_2006_J.Am.Chem.Soc_128_9699 |
| PubMedID: 16866524 |
| Title : Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha\/beta-hydrolase 4 in this pathway - Simon_2006_J.Biol.Chem_281_26465 |
| Author(s) : Simon GM , Cravatt BF |
| Ref : Journal of Biological Chemistry , 281 :26465 , 2006 |
| Abstract : |
| PubMedSearch : Simon_2006_J.Biol.Chem_281_26465 |
| PubMedID: 16818490 |
| Gene_locus related to this paper: human-ABHD4 |
| Title : Proteomic profiling of metalloprotease activities with cocktails of active-site probes - Sieber_2006_Nat.Chem.Biol_2_274 |
| Author(s) : Sieber SA , Niessen S , Hoover HS , Cravatt BF |
| Ref : Nat Chemical Biology , 2 :274 , 2006 |
| Abstract : |
| PubMedSearch : Sieber_2006_Nat.Chem.Biol_2_274 |
| PubMedID: 16565715 |
| Title : Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions - Nomura_2006_Chem.Res.Toxicol_19_1142 |
| Author(s) : Nomura DK , Durkin KA , Chiang KP , Quistad GB , Cravatt BF , Casida JE |
| Ref : Chemical Research in Toxicology , 19 :1142 , 2006 |
| Abstract : |
| PubMedSearch : Nomura_2006_Chem.Res.Toxicol_19_1142 |
| PubMedID: 16978018 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling - Chiang_2006_Chem.Biol_13_1041 |
| Author(s) : Chiang KP , Niessen S , Saghatelian A , Cravatt BF |
| Ref : Chemical Biology , 13 :1041 , 2006 |
| Abstract : |
| PubMedSearch : Chiang_2006_Chem.Biol_13_1041 |
| PubMedID: 17052608 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : A brain detoxifying enzyme for organophosphorus nerve poisons - Nomura_2005_Proc.Natl.Acad.Sci.U.S.A_102_6195 |
| Author(s) : Nomura DK , Leung D , Chiang KP , Quistad GB , Cravatt BF , Casida JE |
| Ref : Proc Natl Acad Sci U S A , 102 :6195 , 2005 |
| Abstract : |
| PubMedSearch : Nomura_2005_Proc.Natl.Acad.Sci.U.S.A_102_6195 |
| PubMedID: 15840715 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity - Lichtman_2004_J.Pharmacol.Exp.Ther_311_441 |
| Author(s) : Lichtman AH , Leung D , Shelton CC , Saghatelian A , Hardouin C , Boger DL , Cravatt BF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 311 :441 , 2004 |
| Abstract : |
| PubMedSearch : Lichtman_2004_J.Pharmacol.Exp.Ther_311_441 |
| PubMedID: 15229230 |
| Title : Discovering potent and selective reversible inhibitors of enzymes in complex proteomes - Leung_2003_Nat.Biotechnol_21_687 |
| Author(s) : Leung D , Hardouin C , Boger DL , Cravatt BF |
| Ref : Nat Biotechnol , 21 :687 , 2003 |
| Abstract : |
| PubMedSearch : Leung_2003_Nat.Biotechnol_21_687 |
| PubMedID: 12740587 |
| Title : Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness - Jessani_2002_Proc.Natl.Acad.Sci.U.S.A_99_10335 |
| Author(s) : Jessani N , Liu Y , Humphrey M , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 99 :10335 , 2002 |
| Abstract : |
| PubMedSearch : Jessani_2002_Proc.Natl.Acad.Sci.U.S.A_99_10335 |
| PubMedID: 12149457 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : Profiling serine hydrolase activities in complex proteomes - Kidd_2001_Biochemistry_40_4005 |
| Author(s) : Kidd D , Liu Y , Cravatt BF |
| Ref : Biochemistry , 40 :4005 , 2001 |
| Abstract : |
| PubMedSearch : Kidd_2001_Biochemistry_40_4005 |
| PubMedID: 11300781 |
| Title : Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase - Cravatt_2001_Proc.Natl.Acad.Sci.U.S.A_98_9371 |
| Author(s) : Cravatt BF , Demarest K , Patricelli MP , Bracey MH , Giang DK , Martin BR , Lichtman AH |
| Ref : Proc Natl Acad Sci U S A , 98 :9371 , 2001 |
| Abstract : |
| PubMedSearch : Cravatt_2001_Proc.Natl.Acad.Sci.U.S.A_98_9371 |
| PubMedID: 11470906 |
| Title : Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide - Boger_2000_Proc.Natl.Acad.Sci.U.S.A_97_5044 |
| Author(s) : Boger DL , Sato H , Lerner AE , Hedrick MP , Fecik RA , Miyauchi H , Wilkie GD , Austin BJ , Patricelli MP , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 97 :5044 , 2000 |
| Abstract : |
| PubMedSearch : Boger_2000_Proc.Natl.Acad.Sci.U.S.A_97_5044 |
| PubMedID: 10805767 |
| Title : Activity-based protein profiling: the serine hydrolases - Liu_1999_Proc.Natl.Acad.Sci.U.S.A_96_14694 |
| Author(s) : Liu Y , Patricelli MP , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 96 :14694 , 1999 |
| Abstract : |
| PubMedSearch : Liu_1999_Proc.Natl.Acad.Sci.U.S.A_96_14694 |
| PubMedID: 10611275 |