JW8
AChE IC50 = 0.056 microM. active against the BACE1 IC50 9.01 microM; hDHFR IC50 12.15 +/6 0.02
General
Type : Multitarget, BACE1-inhibitor, Benzamide
Chemical_Nomenclature : 3-methoxy-N-[4-[(3-methoxybenzoyl)amino]phenyl]benzamide
Canonical SMILES : COC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)OC
InChI : InChI=1S\/C22H20N2O4\/c1-27-19-7-3-5-15(13-19)21(25)23-17-9-11-18(12-10-17)24-22(26)16-6-4-8-20(14-16)28-2\/h3-14H,1-2H3,(H,23,25)(H,24,26)
InChIKey : UHVGQMSTKRPOGN-UHFFFAOYSA-N
Other name(s) : Oprea1_231849 || STK429057 || AKOS003307708 || N,N'-benzene-1,4-diylbis(3-methoxybenzamide)
MW : 376.4
Formula : C22H20N2O4
CAS_number :
PubChem : 5058564
UniChem : UHVGQMSTKRPOGN-UHFFFAOYSA-N
Target
Families : JW8 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (2)
| Title : Benzamide Trimethoprim Derivatives as Human Dihydrofolate Reductase Inhibitors-Molecular Modeling and In Vitro Activity Study - Drozdowska_2024_Biomedicines_12_1079 |
| Author(s) : Drozdowska D , Wrobel-Talalaj A , Parzych C , Ratkiewicz A |
| Ref : Biomedicines , 12 :1079 , 2024 |
| Abstract : |
| PubMedSearch : Drozdowska_2024_Biomedicines_12_1079 |
| PubMedID: 38791041 |
| Title : New Benzamides as Multi-Targeted Compounds: A Study on Synthesis, AChE and BACE1 Inhibitory Activity and Molecular Docking - Drozdowska_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Drozdowska D , Maliszewski D , Wrobel A , Ratkiewicz A , Sienkiewicz M |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Drozdowska_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37834347 |