KV-1234
KV-1234 IC50 0.85 microM AChE; IC50 0.79 microM MAO-B
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Quinazoline, Pyrrolidine
Chemical_Nomenclature : 4-Phenyl-8-(prop-2-yn-1-yloxy)-2-(pyrrolidin-1-yl)-5,6-dihydrobenzo[h]quinazoline
Canonical SMILES : C1=CC=CC=C1C2=NC(=NC3=C2CCC4=C3C=CC(=C4)OCC#C)N5CCCC5
InChI : InChI=1S\/C25H23N3O\/c1-2-16-29-20-11-13-21-19(17-20)10-12-22-23(18-8-4-3-5-9-18)26-25(27-24(21)22)28-14-6-7-15-28\/h1,3-5,8-9,11,13,17H,6-7,10,12,14-16H2
InChIKey : WBBZXVWNAOBLKA-UHFFFAOYSA-N
Other name(s) :
Target
Families : KV-1234 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : ML-based prediction to experimental validation: Development of dihydroquinazoline based multi-potent ligands as anti-Alzheimer's agents - Jangid_2025_Comput.Biol.Med_196_110762 |
| Author(s) : Jangid K , Devi B , Kumar N , Upadhayay S , Kumar V , Thareja S |
| Ref : Computers in Biology & Medicine , 196 :110762 , 2025 |
| Abstract : |
| PubMedSearch : Jangid_2025_Comput.Biol.Med_196_110762 |
| PubMedID: 40664126 |