L4R1-3
IC50 AChE 4.6 +/- 0.1 nM; BChE 66.1 +/- 3.3 microM
General
Type : Quinoline
Chemical_Nomenclature : 2-(diethylaminomethyl)-4-[(6,7-dimethoxyquinolin-4-yl)amino]phenol
Canonical SMILES : CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=C(C(=CC3=NC=C2)OC)OC)O
InChI : InChI=1S\/C22H27N3O3\/c1-5-25(6-2)14-15-11-16(7-8-20(15)26)24-18-9-10-23-19-13-22(28-4)21(27-3)12-17(18)19\/h7-13,26H,5-6,14H2,1-4H3,(H,23,24)
InChIKey : AVDCOCFGLOPLGP-UHFFFAOYSA-N
Other name(s) :
MW : 381.5
Formula : C22H27N3O3
CAS_number :
PubChem : 73891811
UniChem : AVDCOCFGLOPLGP-UHFFFAOYSA-N
Target
Families : L4R1-3 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Fragment-informed SAR: rational construction of quinoline derivatives as dual AChE\/BChE inhibitors - Sun_2025_Bioorg.Chem_163_108747 |
| Author(s) : Sun D , Bi H , Ma L , Zhu Y , Nie HF , Liu A , Li Y , Luo L , Liu X , Zhao M , Wei Z |
| Ref : Bioorg Chem , 163 :108747 , 2025 |
| Abstract : |
| PubMedSearch : Sun_2025_Bioorg.Chem_163_108747 |
| PubMedID: 40682972 |
| Title : Fragment-informed SAR: rational construction of quinoline derivatives as dual AChE\/BChE inhibitors - Sun_2025_Bioorg.Chem_163_108747 |
| Author(s) : Sun D , Bi H , Ma L , Zhu Y , Nie HF , Liu A , Li Y , Luo L , Liu X , Zhao M , Wei Z |
| Ref : Bioorg Chem , 163 :108747 , 2025 |
| Abstract : |
| PubMedSearch : Sun_2025_Bioorg.Chem_163_108747 |
| PubMedID: 40682972 |
| Title : Fragment-informed SAR: rational construction of quinoline derivatives as dual AChE\/BChE inhibitors - Sun_2025_Bioorg.Chem_163_108747 |
| Author(s) : Sun D , Bi H , Ma L , Zhu Y , Nie HF , Liu A , Li Y , Luo L , Liu X , Zhao M , Wei Z |
| Ref : Bioorg Chem , 163 :108747 , 2025 |
| Abstract : |
| PubMedSearch : Sun_2025_Bioorg.Chem_163_108747 |
| PubMedID: 40682972 |