LB05
AChE IC50 0.40 +/- 0.011 microM; BChE 31.55 +/- 0.32 % inhibition at 10microM
General
Type : Piperazine, Thiazole, Benzothiazol, Sulfur Compound, Organochlorine
Chemical_Nomenclature : N-(6-chlorobenzo[d]thiazol-2-yl)-2-(4-(4-fluorobenzoyl)piperazin-1-yl)acetamide
Canonical SMILES : S1C(=NC2=CC=C(C=C12)Cl)NC(CN3CCN(CC3)C(C4=CC=C(C=C4)F)=O)=O
InChI : InChI=1S\/C20H18ClFN4O2S\/c21-14-3-6-16-17(11-14)29-20(23-16)24-18(27)12-25-7-9-26(10-8-25)19(28)13-1-4-15(22)5-2-13\/h1-6,11H,7-10,12H2,(H,23,24,27)
InChIKey : CHDXKKZNSGIIMQ-UHFFFAOYSA-N
Other name(s) :
Target
Families : LB05 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Novel benzothiazole-based cholinesterase inhibitors with amyloid beta disaggregation and antioxidant activity against Alzheimer's disease - Bhardwaj_2025_Eur.J.Med.Chem_298_118047 |
| Author(s) : Bhardwaj B , Vishwakarma SK , Singh A , Kumar H , Gajendra TA , Verma A , Krishnamurthy S , Davisson VJ , Shrivastava SK |
| Ref : Eur Journal of Medicinal Chemistry , 298 :118047 , 2025 |
| Abstract : |
| PubMedSearch : Bhardwaj_2025_Eur.J.Med.Chem_298_118047 |
| PubMedID: 40784304 |
| Title : Novel benzothiazole-based cholinesterase inhibitors with amyloid beta disaggregation and antioxidant activity against Alzheimer's disease - Bhardwaj_2025_Eur.J.Med.Chem_298_118047 |
| Author(s) : Bhardwaj B , Vishwakarma SK , Singh A , Kumar H , Gajendra TA , Verma A , Krishnamurthy S , Davisson VJ , Shrivastava SK |
| Ref : Eur Journal of Medicinal Chemistry , 298 :118047 , 2025 |
| Abstract : |
| PubMedSearch : Bhardwaj_2025_Eur.J.Med.Chem_298_118047 |
| PubMedID: 40784304 |
| Title : Novel benzothiazole-based cholinesterase inhibitors with amyloid beta disaggregation and antioxidant activity against Alzheimer's disease - Bhardwaj_2025_Eur.J.Med.Chem_298_118047 |
| Author(s) : Bhardwaj B , Vishwakarma SK , Singh A , Kumar H , Gajendra TA , Verma A , Krishnamurthy S , Davisson VJ , Shrivastava SK |
| Ref : Eur Journal of Medicinal Chemistry , 298 :118047 , 2025 |
| Abstract : |
| PubMedSearch : Bhardwaj_2025_Eur.J.Med.Chem_298_118047 |
| PubMedID: 40784304 |