Lactam-triazole-cpd4m
IC50 0.7 microM for AChE; 0.2 microM for BChE
General
Type : Piperidine, Triazol, Delta-lactam
Chemical_Nomenclature : 1-(4-(4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl)-3-fluorophenyl) piperidin-2-one
Canonical SMILES : C1CN(C(CC1)=O)C2=CC(=C(C=C2)[N]3N=NC(=C3)C4=CC=C(C=C4)Cl)F
InChI : InChI=1S\/C19H16ClFN4O\/c20-14-6-4-13(5-7-14)17-12-25(23-22-17)18-9-8-15(11-16(18)21)24-10-2-1-3-19(24)26\/h4-9,11-12H,1-3,10H2
InChIKey : GQXHRJPVTLDTAM-UHFFFAOYSA-N
Other name(s) : Compound 4m
Target
Families : Lactam-triazole-cpd4m ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Dual cholinesterase inhibition by lactam-1,2,3-triazole hybrids: A click chemistry approach for drug discovery - Cavallaro_2025_Bioorg.Chem_163_108643 |
| Author(s) : Cavallaro V , Bjerg EE , Rojas M , Santana-Romo F , Murray AP , Radivoy G , Duarte Y , Zacconi FC , Moglie Y |
| Ref : Bioorg Chem , 163 :108643 , 2025 |
| Abstract : |
| PubMedSearch : Cavallaro_2025_Bioorg.Chem_163_108643 |
| PubMedID: 40460609 |