M513
Indoxacarb Indoxacarb acts against lepidopteran larvae. It has a role as a voltage-gated sodium channel blocker. In 2021, the European Union chose not to renew Indoxacarb for use as an insecticide. The United Kingdom still allows use of the compound until 2025. N-decarbomethoxylated metabolite DCJW(DCJW) is the active compound. Indoxacarb is degraded by SlituCOE067 into DCJW. Down regulation of this carboxylesterase reduced the sensitivity of larvae to indoxacarb. Overexpression has the opposite effect Shi et al 2025. Another metabolite M513''M513) is produced by another enzyme and is not toxic as DCJW Zou et al 2025
General
Type : Insecticide, Carboxamide, Carbamate, Trifluoro, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : (4aS)-7-chloro-2-[methoxycarbonyl-[4-(trifluoromethoxy)phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylic acid
Canonical SMILES : COC(=O)N(C1=CC=C(C=C1)OC(F)(F)F)C(=O)N2CO[C@]3(CC4=C(C3=N2)C=CC(=C4)Cl)C(=O)O
InChI : InChI=1S\/C21H15ClF3N3O7\/c1-33-19(32)28(13-3-5-14(6-4-13)35-21(23,24)25)18(31)27-10-34-20(17(29)30)9-11-8-12(22)2-7-15(11)16(20)26-27\/h2-8H,9-10H2,1H3,(H,29,30)\/t20-\/m0\/s1
InChIKey : XOXDHIDUKJHVKB-FQEVSTJZSA-N
Other name(s) : SCHEMBL5711896
MW : 513.799
Formula : C21H15ClF3N3O7
CAS_number :
PubChem : 69540130
UniChem : XOXDHIDUKJHVKB-FQEVSTJZSA-N
Target
References (1)
| Title : Metabolic mechanism of a novel carboxylesterase YvaK in Priestia aryabhattai DPX-1 for carbamate insecticide indoxacarb detoxification - Zou_2025_J.Hazard.Mater_495_139087 |
| Author(s) : Zou P , Li Z , Li S , Geng Y , Ma X , Wu X , Hua R , Fang L |
| Ref : J Hazard Mater , 495 :139087 , 2025 |
| Abstract : |
| PubMedSearch : Zou_2025_J.Hazard.Mater_495_139087 |
| PubMedID: 40609465 |
| Gene_locus related to this paper: bacld-q65eq1 , bacmd-d5dna5 |