Magnolol
human-CES1 IC50 0.39 +/- 0.03 microM; Ki 0.0940microM; Competitive inhibition
General
Type : Natural, Lignan, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
Canonical SMILES : C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O
InChI : InChI=1S\/C18H18O2\/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20\/h3-4,7-12,19-20H,1-2,5-6H2
InChIKey : VVOAZFWZEDHOOU-UHFFFAOYSA-N
Other name(s) : 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol || 5,5'-Diallyl-2,2'-biphenyldiol || 2,2'-Bichavicol || 5,5'-Diallyl-2,2'-dihydroxybiphenyl || Dehydrodichavicol || 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol || SCHEMBL132477 || CHEMBL180920 || CHEBI:6643
MW : 266.3
Formula : C18H18O2
CAS_number : 528-43-8
PubChem : 72300
UniChem : VVOAZFWZEDHOOU-UHFFFAOYSA-N
Target
Families : Magnolol ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES1
References (3)
| Title : Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation - Mu_2025_J.Enzyme.Inhib.Med.Chem_40_2472817 |
| Author(s) : Mu J , Chen SS , Li SQ , Jin Q , Geng J , Zou LW |
| Ref : J Enzyme Inhib Med Chem , 40 :2472817 , 2025 |
| Abstract : |
| PubMedSearch : Mu_2025_J.Enzyme.Inhib.Med.Chem_40_2472817 |
| PubMedID: 40207794 |
| Title : Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation - Mu_2025_J.Enzyme.Inhib.Med.Chem_40_2472817 |
| Author(s) : Mu J , Chen SS , Li SQ , Jin Q , Geng J , Zou LW |
| Ref : J Enzyme Inhib Med Chem , 40 :2472817 , 2025 |
| Abstract : |
| PubMedSearch : Mu_2025_J.Enzyme.Inhib.Med.Chem_40_2472817 |
| PubMedID: 40207794 |
| Title : Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation - Mu_2025_J.Enzyme.Inhib.Med.Chem_40_2472817 |
| Author(s) : Mu J , Chen SS , Li SQ , Jin Q , Geng J , Zou LW |
| Ref : J Enzyme Inhib Med Chem , 40 :2472817 , 2025 |
| Abstract : |
| PubMedSearch : Mu_2025_J.Enzyme.Inhib.Med.Chem_40_2472817 |
| PubMedID: 40207794 |