Methiocarb-sulfone
metabolite of methiocarb || Metabolite of methiocarb hCES2 IC50 0.06 microM; Noncompetitive; Ki 0.59 microM
General
Type : Carbamate, Insecticide, Sulfur Compound
Chemical_Nomenclature : (3,5-dimethyl-4-methylsulfonylphenyl) N-methylcarbamate
Canonical SMILES : CC1=CC(=CC(=C1S(=O)(=O)C)C)OC(=O)NC
InChI : InChI=1S\/C11H15NO4S\/c1-7-5-9(16-11(13)12-3)6-8(2)10(7)17(4,14)15\/h5-6H,1-4H3,(H,12,13)
InChIKey : RJBJMKAMQIOAML-UHFFFAOYSA-N
Other name(s) : Methiocarb sulfone || Mesurol sulfone || Mercaptodimethursulfon || Bayer 37344 sulfone || BAY 37344 sulfone || U9FTK96C2O || BAY 41790 || SCHEMBL5933707
MW : 257.31
Formula : C11H15NO4S
CAS_number : 2179-25-1
PubChem : 16589
UniChem : RJBJMKAMQIOAML-UHFFFAOYSA-N
Target
Families : Methiocarb-sulfone ligand of proteins in family
Carb_B_Chordata
Protein :
human-CES2
References (2)
| Title : Evaluation of the inhibitory effects of carbamate pesticides on human carboxylesterases - Liao_2025_Toxicol.Appl.Pharmacol__117454 |
| Author(s) : Liao CY , Yi XL , Yang YX , Gong JM , Ma YL , Long F , Liu ZZ , Du Z |
| Ref : Toxicol Appl Pharmacol , :117454 , 2025 |
| Abstract : |
| PubMedSearch : Liao_2025_Toxicol.Appl.Pharmacol__117454 |
| PubMedID: 40588104 |
| Title : Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARalpha activities - Fujino_2016_J.Toxicol.Sci_41_677 |
| Author(s) : Fujino C , Tamura Y , Tange S , Nakajima H , Sanoh S , Watanabe Y , Uramaru N , Kojima H , Yoshinari K , Ohta S , Kitamura S |
| Ref : Journal of Toxicological Sciences , 41 :677 , 2016 |
| Abstract : |
| PubMedSearch : Fujino_2016_J.Toxicol.Sci_41_677 |
| PubMedID: 27665777 |