Methoxyphenyl-thiazol-2-aminothiazole-morpholin-Cpd14s
AChE: IC50 = 3.47 microM; BuChE: IC50 = 17.31 microM
General
Type : Thiazole, Sulfur Compound, Morpholine, Isophthalamide, Carboxamide, Antioxidant
Chemical_Nomenclature : N-[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]-N-({3-[N-2-(morpholin-4-yl)ethylcarbamoyl]phenyl}methyl)-benzene-1,3-dicarboxamide
Canonical SMILES : C1(=CC=CC(=C1)C(NCC2=CC=CC(=C2)C(NCCN3CCOCC3)=O)=O)C(NC4=NC(=CS4)C5=CC=CC=C5OC)=O
InChI : InChI=1S\/C32H33N5O5S\/c1-41-28-11-3-2-10-26(28)27-21-43-32(35-27)36-31(40)25-9-5-8-24(19-25)30(39)34-20-22-6-4-7-23(18-22)29(38)33-12-13-37-14-16-42-17-15-37\/h2-11,18-19,21H,12-17,20H2,1H3,(H,33,38)(H,34,39)(H,35,36,40)
InChIKey : JUBJCVROLQNVRP-UHFFFAOYSA-N
Other name(s) : Compound 14s || N-[4-(o-Methoxyphenyl)-1,3-thiazol-2-yl]-N-{[m-(N-2-morpholinoethylcarbamoyl)phenyl]methyl}isophthalamide
Target
References (1)
| Title : Design, synthesis, biological evaluation, and in silico studies of cholinesterase inhibitors based on the 2-aminothiazole scaffold - Du_2025_Med.Chem.Res_34_2162 |
| Author(s) : Du WR , Zhou XW , Wang YX , Ma ZY |
| Ref : Med Chem Res , 34 :2162 , 2025 |
| Abstract : |
| PubMedSearch : Du_2025_Med.Chem.Res_34_2162 |
| PubMedID: |