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Morpholine

General

Morpholine is an organic chemical compound having the chemical formula O(CH2CH2)2NH. This heterocycle features both amine and ether functional groups. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
Methoxyphenyl-thiazol-2-aminothiazole-morpholin-Cpd14s Thiazole Sulfur Compound Morpholine Isophthalamide Carboxamide
4-thiomorpholinophenyl-thiosemicarbazone-Cpd3l BCHE ACHE Sulfur Compound Morpholine Hydrazide Urea derivative
4-thiomorpholinophenyl-thiosemicarbazone-Cpd3n BCHE ACHE Sulfur Compound Morpholine Hydrazide Urea derivative
VAV-8 ACHE Monoamine-oxidase-inhibitor Multitarget Morpholine Quinazoline Piperidine Alkyne
Morpholino-sulfonyl-indole-carbothioamide-Cpd6h ACHE Sulfur Compound Morpholine Indole Sulfonamide Urea derivative
Morpholino-phenylhydrazine-carbothioamide-Cpd6 ACHE BCHE Sulfur Compound Morpholine Hydrazide Urea derivative
Morpholino-phenylthiazolidin-one-Cpd12 ACHE BCHE Thiazolidine Thiazole Sulfur Compound Morpholine Hydrazide
KV-1131 ACHE Monoamine-oxidase-inhibitor Multitarget Quinazoline Sulfur Compound Morpholine
Resveratrol-carbamate-cpdF BCHE Carbamate Sulfur Compound Multitarget Antioxidant Thiophen Morpholine
Nitrophenyl-thiophen-morpholinyl-phenyl-pyrazoline-2l ACHE Sulfur Compound Pyrazole Morpholine Thiophen Pyrazoline
Fluoromethylphenyl-sulfamoyl-phenyl-morpholin-methyl-benzamide Sulfur Compound Sulfonamide Benzamide Morpholine
Lyplal1-IN-1 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Morpholine Pyrimidine
Aryl-carboxamide-benzoxazole-cpd36 BCHE ACHE Carboxamide Benzoxazol Morpholine
76-0079 Hormone-sensitive_lipase_like Morpholine Organochlorine
SCHEMBL19582562 ABHD6-Lip Morpholine Carbamate Trifluoro Azaspiro
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine Organochlorine
JZP-430 ABHD6-Lip Carbamate Morpholine Sulfur Compound Thiadiazol
CHEMBL1610004-P9 PAF-Acetylhydrolase Morpholine Biphenyl
CHEMBL3793506 PAF-Acetylhydrolase Trifluoro Cyanide Pyrimidine Morpholine
S16-1029 BCHE Benzimidazole Oxadiazol Morpholine Carboxamide
SBP-7957 Thioesterase Morpholine Thiazolidine Sulfur Compound Sulfonamide Thiazole
Fragment-705 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine
Fragment-714 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine Naphthalen
Fragment-199 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine
Fragment-609 Pectinacetylesterase-Notum Fragment inhibitor of Notum Thiomorpholine Sulfur Compound
CHEMBL3233609-S0K-3WKD Epoxide_hydrolase Carboxamide Sulfur Compound Morpholine Thiophen
6KZ-4CIA Carboxypeptidase_S10 Carboxamide Morpholine Oxadiazol
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
SCHEMBL15589912 Lipoprotein_Lipase Benzothiazol Sulfur Compound Thiazolidine Morpholine Oxadiazol Sulfonyl
Morpholino-Talinolol Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand Morpholine tert-Butyl
TAM5 Thioesterase Benzofuran Morpholine
CHEMBL1214943 DPP4N_Peptidase_S9 Pyrimidine Morpholine Organochlorine
1-(2-Morpholine-acetamido)-tanshinone-IIA Monoglyceridelipase_lysophospholip Benzofuran Morpholine Tanshinone
2-(N-Morpholino)ethanesulfonic-acid LYsophospholipase_carboxylesterase S9N_PPCE_Peptidase_S9 Buffer Component Sulfur Compound Morpholine
5ALP-QYD Epoxide_hydrolase Carboxamide Sulfur Compound Thiomorpholine pNP Morpholine
CHEMBL3086040 Prolylcarboxypeptidase Pyridine Carboxamide Morpholine
CHEMBL3792924 PAF-Acetylhydrolase Trifluoro Sulfur Compound Thiomorpholine
CHEMBL49895 Hormone-sensitive_lipase_like Carbamate tert-Butyl Morpholine
MF231 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
MF217 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
MF268 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
Morfamquat ACHE Pyridine Herbicide Morpholine
Rocuronium Neuromuscular Nondepolarizing Agents Aminosteroid Drug Not AlphaBeta Hydrolase target Morpholine Phenanthrene
Methoxyphenyl-thiazol-2-aminothiazole-morpholin-Cpd14s Thiazole Sulfur compound Morpholine Isophthalamide Carboxamide
4-thiomorpholinophenyl-thiosemicarbazone-Cpd3l BCHE ACHE Sulfur compound Morpholine Hydrazide Urea derivative
4-thiomorpholinophenyl-thiosemicarbazone-Cpd3n BCHE ACHE Sulfur compound Morpholine Hydrazide Urea derivative
VAV-8 ACHE Monoamine-oxidase-inhibitor Multitarget Morpholine Quinazoline Piperidine Alkyne
Morpholino-sulfonyl-indole-carbothioamide-Cpd6h ACHE Sulfur compound Morpholine Indole Sulfonamide Urea derivative
Morpholino-phenylhydrazine-carbothioamide-Cpd6 ACHE BCHE Sulfur compound Morpholine Hydrazide Urea derivative
Morpholino-phenylthiazolidin-one-Cpd12 ACHE BCHE Thiazolidine Thiazole Sulfur compound Morpholine Hydrazide
KV-1131 ACHE Monoamine-oxidase-inhibitor Multitarget Quinazoline Sulfur compound Morpholine
Resveratrol-carbamate-cpdF BCHE Carbamate Sulfur compound Multitarget Antioxidant Thiophen Morpholine
Nitrophenyl-thiophen-morpholinyl-phenyl-pyrazoline-2l ACHE Sulfur compound Pyrazole Morpholine Thiophen Pyrazoline
Fluoromethylphenyl-sulfamoyl-phenyl-morpholin-methyl-benzamide Sulfur compound Sulfonamide Benzamide Morpholine
Lyplal1-IN-1 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Morpholine Pyrimidine
Aryl-carboxamide-benzoxazole-cpd36 BCHE ACHE Carboxamide Benzoxazol Morpholine
76-0079 Hormone-sensitive_lipase_like Morpholine Organochlorine
SCHEMBL19582562 ABHD6-Lip Morpholine Carbamate Trifluoro Azaspiro
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine Organochlorine
JZP-430 ABHD6-Lip Carbamate Morpholine Sulfur compound Thiadiazol
CHEMBL1610004-P9 PAF-Acetylhydrolase Morpholine Biphenyl
CHEMBL3793506 PAF-Acetylhydrolase Trifluoro Cyanide Pyrimidine Morpholine
S16-1029 BCHE Benzimidazole Oxadiazol Morpholine Carboxamide
SBP-7957 Thioesterase Morpholine Thiazolidine Sulfur compound Sulfonamide Thiazole
Fragment-705 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine
Fragment-714 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine Naphthalen
Fragment-199 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine
Fragment-609 Pectinacetylesterase-Notum Fragment inhibitor of Notum Thiomorpholine Sulfur compound
CHEMBL3233609-S0K-3WKD Epoxide_hydrolase Carboxamide Sulfur compound Morpholine Thiophen
6KZ-4CIA Carboxypeptidase_S10 Carboxamide Morpholine Oxadiazol
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
SCHEMBL15589912 Lipoprotein_Lipase Benzothiazol Sulfur compound Thiazolidine Morpholine Oxadiazol Sulfonyl
Morpholino-Talinolol Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand Morpholine tert-Butyl
TAM5 Thioesterase Benzofuran Morpholine
CHEMBL1214943 DPP4N_Peptidase_S9 Pyrimidine Morpholine Organochlorine
1-(2-Morpholine-acetamido)-tanshinone-IIA Monoglyceridelipase_lysophospholip Benzofuran Morpholine Tanshinone
2-(N-Morpholino)ethanesulfonic-acid LYsophospholipase_carboxylesterase S9N_PPCE_Peptidase_S9 Buffer Component Sulfur compound Morpholine
5ALP-QYD Epoxide_hydrolase Carboxamide Sulfur compound Thiomorpholine pNP Morpholine
CHEMBL3086040 Prolylcarboxypeptidase Pyridine Carboxamide Morpholine
CHEMBL3792924 PAF-Acetylhydrolase Trifluoro Sulfur compound Thiomorpholine
CHEMBL49895 Hormone-sensitive_lipase_like Carbamate tert-Butyl Morpholine
MF231 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
MF217 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
MF268 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
Morfamquat ACHE Pyridine Herbicide Morpholine
Rocuronium Neuromuscular Nondepolarizing Agents Aminosteroid Drug Not AlphaBeta Hydrolase target Morpholine Phenanthrene
Methoxyphenyl-thiazol-2-aminothiazole-morpholin-Cpd14s Thiazole Sulfur compound Morpholine Isophthalamide Carboxamide
4-thiomorpholinophenyl-thiosemicarbazone-Cpd3l BCHE ACHE Sulfur compound Morpholine Hydrazide Urea derivative
4-thiomorpholinophenyl-thiosemicarbazone-Cpd3n BCHE ACHE Sulfur compound Morpholine Hydrazide Urea derivative
VAV-8 ACHE Monoamine-oxidase-inhibitor Multitarget Morpholine Quinazoline Piperidine Alkyne
Morpholino-sulfonyl-indole-carbothioamide-Cpd6h ACHE Sulfur compound Morpholine Indole Sulfonamide Urea derivative
Morpholino-phenylhydrazine-carbothioamide-Cpd6 ACHE BCHE Sulfur compound Morpholine Hydrazide Urea derivative
Morpholino-phenylthiazolidin-one-Cpd12 ACHE BCHE Thiazolidine Thiazole Sulfur compound Morpholine Hydrazide
KV-1131 ACHE Monoamine-oxidase-inhibitor Multitarget Quinazoline Sulfur compound Morpholine
Resveratrol-carbamate-cpdF BCHE Carbamate Sulfur compound Multitarget Antioxidant Thiophen Morpholine
Nitrophenyl-thiophen-morpholinyl-phenyl-pyrazoline-2l ACHE Sulfur compound Pyrazole Morpholine Thiophen Pyrazoline
Fluoromethylphenyl-sulfamoyl-phenyl-morpholin-methyl-benzamide Sulfur compound Sulfonamide Benzamide Morpholine
Lyplal1-IN-1 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Morpholine Pyrimidine
Aryl-carboxamide-benzoxazole-cpd36 BCHE ACHE Carboxamide Benzoxazol Morpholine
76-0079 Hormone-sensitive_lipase_like Morpholine Organochlorine
SCHEMBL19582562 ABHD6-Lip Morpholine Carbamate Trifluoro Azaspiro
SCHEMBL20516363 ABHD6-Lip PAF-Acetylhydrolase Piperazine Imidazole Carbamate Morpholine Organochlorine
JZP-430 ABHD6-Lip Carbamate Morpholine Sulfur compound Thiadiazol
CHEMBL1610004-P9 PAF-Acetylhydrolase Morpholine Biphenyl
CHEMBL3793506 PAF-Acetylhydrolase Trifluoro Cyanide Pyrimidine Morpholine
S16-1029 BCHE Benzimidazole Oxadiazol Morpholine Carboxamide
SBP-7957 Thioesterase Morpholine Thiazolidine Sulfur compound Sulfonamide Thiazole
Fragment-705 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine
Fragment-714 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine Naphthalen
Fragment-199 Pectinacetylesterase-Notum Fragment inhibitor of Notum Morpholine
Fragment-609 Pectinacetylesterase-Notum Fragment inhibitor of Notum Thiomorpholine Sulfur compound
CHEMBL3233609-S0K-3WKD Epoxide_hydrolase Carboxamide Sulfur compound Morpholine Thiophen
6KZ-4CIA Carboxypeptidase_S10 Carboxamide Morpholine Oxadiazol
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur compound Sulfonamide Morpholine Pyrazole
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
SCHEMBL15589912 Lipoprotein_Lipase Benzothiazol Sulfur compound Thiazolidine Morpholine Oxadiazol Sulfonyl
Morpholino-Talinolol Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand Morpholine tert-Butyl
TAM5 Thioesterase Benzofuran Morpholine
CHEMBL1214943 DPP4N_Peptidase_S9 Pyrimidine Morpholine Organochlorine
1-(2-Morpholine-acetamido)-tanshinone-IIA Monoglyceridelipase_lysophospholip Benzofuran Morpholine Tanshinone
2-(N-Morpholino)ethanesulfonic-acid LYsophospholipase_carboxylesterase S9N_PPCE_Peptidase_S9 Buffer Component Sulfur compound Morpholine
5ALP-QYD Epoxide_hydrolase Carboxamide Sulfur compound Thiomorpholine pNP Morpholine
CHEMBL3086040 Prolylcarboxypeptidase Pyridine Carboxamide Morpholine
CHEMBL3792924 PAF-Acetylhydrolase Trifluoro Sulfur compound Thiomorpholine
CHEMBL49895 Hormone-sensitive_lipase_like Carbamate tert-Butyl Morpholine
MF231 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
MF217 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
MF268 ACHE Derivative of physostigmine-eserine Stigmine Carbamate Morpholine Indole
Morfamquat ACHE Pyridine Herbicide Morpholine
Rocuronium Neuromuscular Nondepolarizing Agents Aminosteroid Drug Not AlphaBeta Hydrolase target Morpholine Phenanthrene