Oxo-phenyl-chromen-quinoline-sulfonate-Cpd5
AChE IC50 3.96 nM Ki 1.92 +/- 0.07 nM; hCA1 IC50 9.50 nM Ki 9.45 +/- 0.86 nM; hCA1 IC50 57.76 nM Ki 76.62 +/- 25.64 nM; alpha-glycosidase IC50 25.67 nM Ki 32.40 +/- 13.62 nM
General
Type : Sulfur Compound, Sulfonyl, Chromen, Multitarget, Carbonic anhydrase inhibitor, Quinoline, Flavonoid
Chemical_Nomenclature : 4-Oxo-2-phenyl-4H-chromen-3-yl quinoline-8-sulfonate
Canonical SMILES : C1=CC=CC2=C1OC(=C(C2=O)O[S](C3=C4C(=CC=C3)C=CC=N4)(=O)=O)C5=CC=CC=C5
InChI : InChI=1S\/C24H15NO5S\/c26-22-18-12-4-5-13-19(18)29-23(17-8-2-1-3-9-17)24(22)30-31(27,28)20-14-6-10-16-11-7-15-25-21(16)20\/h1-15H
InChIKey : MHWKIAFFHHNYOD-UHFFFAOYSA-N
Other name(s) : Compound 5
Target
Families : Oxo-phenyl-chromen-quinoline-sulfonate-Cpd5 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : In Vitro and in Silico Studies of 3-Hydroxyflavone-Based Sulfonate Esters: Potent Acetylcholinesterase, Carbonic Anhydrase and alpha-Glycosidase Inhibitors - Guney_2023_ChemistrySelect_8_e202303054 |
| Author(s) : Guney Guney M , Aggul AG , Erturk A , Gulcin I |
| Ref : ChemistrySelect , 8 :e202303054 , 2023 |
| Abstract : |
| PubMedSearch : Guney_2023_ChemistrySelect_8_e202303054 |
| PubMedID: |