PGN33
Balanced dual acting butyrylcholinesterase inhibitor and human cannabinoid receptor 2 ligand
General
Type : Multitarget, Cannabinoid-Receptor-ligand, Indazole
Chemical_Nomenclature : N-[2-[3-[(4-methoxyphenyl)methoxy]indazol-1-yl]ethyl]-N-propan-2-ylpropan-2-amine
Canonical SMILES : CC(C)N(CCN1C2=CC=CC=C2C(=N1)OCC3=CC=C(C=C3)OC)C(C)C
InChI : InChI=1S\/C23H31N3O2\/c1-17(2)25(18(3)4)14-15-26-22-9-7-6-8-21(22)23(24-26)28-16-19-10-12-20(27-5)13-11-19\/h6-13,17-18H,14-16H2,1-5H3
InChIKey : CTXLHWVBEFYFSI-UHFFFAOYSA-N
Other name(s) : CHEMBL3116280 || SCHEMBL6854432 || BDBM50447030 || Compound3 || 1-(2-Diisopropylaminoethyl)-3-(4-methoxybenzyloxy)indazole
MW : 436.35 || 381.52
Formula : C23H31N3O2
CAS_number :
PubChem : 51357598
UniChem : CTXLHWVBEFYFSI-UHFFFAOYSA-N
Target
Families : PGN33 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (2)
| Title : Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer's Disease - Del Cerro_2018_CNS.Drugs_32_579 |
| Author(s) : Del Cerro P , Alquezar C , Bartolome F , Gonzalez-Naranjo P , Perez C , Carro E , Paez JA , Campillo NE , Martin-Requero A |
| Ref : CNS Drugs , 32 :579 , 2018 |
| Abstract : |
| PubMedSearch : Del Cerro_2018_CNS.Drugs_32_579 |
| PubMedID: 29736745 |
| Title : Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease - Gonzalez-Naranjo_2014_Eur.J.Med.Chem_73_56 |
| Author(s) : Gonzalez-Naranjo P , Perez-Macias N , Campillo NE , Perez C , Aran VJ , Giron R , Sanchez-Robles E , Martin MI , Gomez-Canas M , Garcia-Arencibia M , Fernandez-Ruiz J , Paez JA |
| Ref : Eur Journal of Medicinal Chemistry , 73 :56 , 2014 |
| Abstract : |
| PubMedSearch : Gonzalez-Naranjo_2014_Eur.J.Med.Chem_73_56 |
| PubMedID: 24378710 |