Penfluridol
One of the long-acting antipsychotic agentsused for maintenance or long-term therapy of schizophrenia and other psychotic disorders. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. Also repurposed as Staphylococcus aureus lipase inhibitor. IC50 value of 7.3 M
General
Type : Not AlphaBeta Hydrolase target, Trifluoro, Piperidine
Chemical_Nomenclature : 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol
Canonical SMILES : C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI : InChI=1S\/C28H27ClF5NO\/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20\/h3-12,18,24,36H,1-2,13-17H2
InChIKey : MDLAAYDRRZXJIF-UHFFFAOYSA-N
Other name(s) : Semap || Penfluridolum || CHEMBL47050 || SCHEMBL93939 || CHEBI:92278 || DB13791 || Micefal || Longoperidol
MW : 524.0
Formula : C28H27ClF5NO
CAS_number : 26864-56-2
PubChem : 33630
UniChem : MDLAAYDRRZXJIF-UHFFFAOYSA-N
Wikipedia : Penfluridol
References (1)
| Title : Structural analysis shows the mode of inhibition for Staphylococcus aureus lipase by antipsychotic penfluridol - Kitadokoro_2025_Sci.Rep_15_11876 |
| Author(s) : Kitadokoro J , Hirokawa T , Kamo M , Furubayashi N , Okuno Y , Hikima T , Yamamoto M , Inaka K , Maenaka K , Kamitani S , Kitadokoro K |
| Ref : Sci Rep , 15 :11876 , 2025 |
| Abstract : |
| PubMedSearch : Kitadokoro_2025_Sci.Rep_15_11876 |
| PubMedID: 40229318 |
| Gene_locus related to this paper: staau-lipas |