staau-lipas

Staphylococcus aureus gene for lipase lip2, lipase 2, geh lipase. Glycerol ester hydrolase 2 gehB Staphylococcus simulans

Comment

Rosenstein R, Gotz F a review on Staphylococcal lipases. There is a long precursor which is cut to a 46kDa active form. Detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus depends on lipase 2. Lip2 detoxifies AFAs via esterification with cholesterol

Relationship

Family : Bacterial_lip_FamI.6

Block : L

Position in NCBI Life Tree : Staphylococcus aureus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Firmicutes N E > Bacilli N E > Bacillales N E > Staphylococcaceae N E > Staphylococcus N E > Staphylococcus aureus N E

Sequence

Peptide

GQNSPEKPTD KNTDNKQLIK DALQAPKTRS TTNAAADAKK VRPLKANQVQ PLNKYPVVFV HGFLGLVGDN APALYPNYWG GNKFKVIEEL RKQGYNVHQA SVSAFGSNYD RAVELYYYIK GGRVDYGAAH AAKYGHERYG KTYKGIMPNW EPGKKVHLVG HSMGGQTIRL MEEFLRNGNK EEIAYHKAHG GEISPLFTGG HNNMVASITT LATPHNGSQA ADKFGNTEAV RKIMFALNRF MGNKYSNIDL GLTQWGFKQL PNESYIDYIK RVSKSKIWTS DDNAAYDLTL DGSAKLNNMT SMNPNITYTT YTGVSSHTGP LGYENPDLGT FFLMATTSRI IGHDAREEWR KNDGVVPVIS SLHPSNQPFV NVTNDEPATR RGIWQVKPII QGWDHVDFIG VDFLDFKRKG AELANFYTGI INDLLRVEAT ESKGTQLKAS

References (30)

Title : The Phospholipase A1 Activity of Glycerol Ester Hydrolase (Geh) Is Responsible for Extracellular 2-12(S)-Methyltetradecanoyl-Lysophosphatidylglycerol Production in Staphylococcus aureus - Subramanian_2023_mSphere__e0003123
Author(s) : Subramanian C , Frank MW , Yun MK , Rock CO
Ref : mSphere , :e0003123 , 2023
PubMedID: 36976028
Gene_locus related to this paper: staau-lipas

Title : Structure elucidation of Staphylococcus capitis lipase. Molecular dynamics simulations to investigate the effects of calcium and zinc ions on the structural stability - Rmili_2022_J.Biomol.Struct.Dyn__1
Author(s) : Rmili F , Frikha F , Chamkha M , Sayari A , Fendri A
Ref : J Biomol Struct Dyn , :1 , 2022
PubMedID: 36546696
Gene_locus related to this paper: staau-lipas

Title : Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat - Kitadokoro_2020_Sci.Rep_10_5469
Author(s) : Kitadokoro K , Tanaka M , Hikima T , Okuno Y , Yamamoto M , Kamitani S
Ref : Sci Rep , 10 :5469 , 2020
PubMedID: 32214208
Gene_locus related to this paper: staau-lipas

Title : Bacterial lipolysis of immune-activating ligands promotes evasion of innate defenses - Chen_2019_Proc.Natl.Acad.Sci.U.S.A_116_3764
Author(s) : Chen X , Alonzo F, 3rd
Ref : Proc Natl Acad Sci U S A , 116 :3764 , 2019
PubMedID: 30755523
Gene_locus related to this paper: staau-LIP , staau-lipas

Title : Staphylococcal (phospho)lipases promote biofilm formation and host cell invasion - Nguyen_2018_Int.J.Med.Microbiol_308_653
Author(s) : Nguyen MT , Luqman A , Bitschar K , Hertlein T , Dick J , Ohlsen K , Broker B , Schittek B , Gotz F
Ref : Int J Med Microbiol , 308 :653 , 2018
PubMedID: 29203111
Gene_locus related to this paper: staau-LIP , staau-lipas , stawa-GEHA

Title : Staphylococcus aureus lipase: purification, kinetic characterization, crystallization and crystallographic study - Tanaka_2018_Acta.Crystallogr.F.Struct.Biol.Commun_74_567
Author(s) : Tanaka M , Kamitani S , Kitadokoro K
Ref : Acta Crystallographica F Struct Biol Commun , 74 :567 , 2018
PubMedID: 30198889
Gene_locus related to this paper: staau-lipas

Title : Role of Lipase from Community-Associated Methicillin-Resistant Staphylococcus aureus Strain USA300 in Hydrolyzing Triglycerides into Growth-Inhibitory Free Fatty Acids - Cadieux_2014_J.Bacteriol_196_4044
Author(s) : Cadieux B , Vijayakumaran V , Bernards MA , McGavin MJ , Heinrichs DE
Ref : Journal of Bacteriology , 196 :4044 , 2014
PubMedID: 25225262
Gene_locus related to this paper: staau-lipas

Title : Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis - Schijffelen_2010_BMC.Genomics_11_376
Author(s) : Schijffelen MJ , Boel CH , van Strijp JA , Fluit AC
Ref : BMC Genomics , 11 :376 , 2010
PubMedID: 20546576
Gene_locus related to this paper: staau-c8mfq3 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594

Title : Complete genome sequence of Staphylococcus aureus strain JKD6159, a unique Australian clone of ST93-IV community methicillin-resistant Staphylococcus aureus - Chua_2010_J.Bacteriol_192_5556
Author(s) : Chua K , Seemann T , Harrison PF , Davies JK , Coutts SJ , Chen H , Haring V , Moore R , Howden BP , Stinear TP
Ref : Journal of Bacteriology , 192 :5556 , 2010
PubMedID: 20729356
Gene_locus related to this paper: staau-c8mfq3 , staau-d2feb3 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2422 , staau-SAV0321 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594

Title : Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation - Guinane_2010_Genome.Biol.Evol_2_454
Author(s) : Guinane CM , Ben Zakour NL , Tormo-Mas MA , Weinert LA , Lowder BV , Cartwright RA , Smyth DS , Smyth CJ , Lindsay JA , Gould KA , Witney A , Hinds J , Bollback JP , Rambaut A , Penades JR , Fitzgerald JR
Ref : Genome Biol Evol , 2 :454 , 2010
PubMedID: 20624747
Gene_locus related to this paper: staau-d2feb3 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594

Title : Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus - Lowder_2009_Proc.Natl.Acad.Sci.U.S.A_106_19545
Author(s) : Lowder BV , Guinane CM , Ben Zakour NL , Weinert LA , Conway-Morris A , Cartwright RA , Simpson AJ , Rambaut A , Nubel U , Fitzgerald JR
Ref : Proc Natl Acad Sci U S A , 106 :19545 , 2009
PubMedID: 19884497
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594

Title : 3-D structure modelling of the Staphylococcus simulans lipase: conformational changes, substrate specificity and novel structural features - Frikha_2008_FEMS.Microbiol.Lett_286_207
Author(s) : Frikha F , Ladjimi M , Gargouri Y , Miled N
Ref : FEMS Microbiology Letters , 286 :207 , 2008
PubMedID: 18662315
Gene_locus related to this paper: staau-lipas

Title : Genome sequencing and analysis reveals possible determinants of Staphylococcus aureus nasal carriage - Sivaraman_2008_BMC.Genomics_9_433
Author(s) : Sivaraman K , Venkataraman N , Tsai J , Dewell S , Cole AM
Ref : BMC Genomics , 9 :433 , 2008
PubMedID: 18808706
Gene_locus related to this paper: staau-lipas , staau-MW0741 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594

Title : Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance - Neoh_2008_Antimicrob.Agents.Chemother_52_45
Author(s) : Neoh HM , Cui L , Yuzawa H , Takeuchi F , Matsuo M , Hiramatsu K
Ref : Antimicrobial Agents & Chemotherapy , 52 :45 , 2008
PubMedID: 17954695
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594

Title : Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands - Baba_2008_J.Bacteriol_190_300
Author(s) : Baba T , Bae T , Schneewind O , Takeuchi F , Hiramatsu K
Ref : Journal of Bacteriology , 190 :300 , 2008
PubMedID: 17951380
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594

Title : Importance of the residue Asp 290 on chain length selectivity and catalytic efficiency of recombinant Staphylococcus simulans lipase expressed in E. coli - Sayari_2007_Mol.Biotechnol_36_14
Author(s) : Sayari A , Mosbah H , Gargouri Y
Ref : Mol Biotechnol , 36 :14 , 2007
PubMedID: 17827533
Gene_locus related to this paper: staau-lipas

Title : Molecular correlates of host specialization in Staphylococcus aureus - Herron-Olson_2007_PLoS.One_2_e1120
Author(s) : Herron-Olson L , Fitzgerald JR , Musser JM , Kapur V
Ref : PLoS ONE , 2 :e1120 , 2007
PubMedID: 17971880
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-SAV0321 , staau-SAV0457 , staau-SAV1793

Title : Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus - Diep_2006_Lancet_367_731
Author(s) : Diep BA , Gill SR , Chang RF , Phan TH , Chen JH , Davidson MG , Lin F , Lin J , Carleton HA , Mongodin EF , Sensabaugh GF , Perdreau-Remington F
Ref : Lancet , 367 :731 , 2006
PubMedID: 16517273
Gene_locus related to this paper: staa3-q2fkj0 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594

Title : Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain - Gill_2005_J.Bacteriol_187_2426
Author(s) : Gill SR , Fouts DE , Archer GL , Mongodin EF , DeBoy RT , Ravel J , Paulsen IT , Kolonay JF , Brinkac L , Beanan M , Dodson RJ , Daugherty SC , Madupu R , Angiuoli SV , Durkin AS , Haft DH , Vamathevan J , Khouri H , Utterback T , Lee C , Dimitrov G , Jiang L , Qin H , Weidman J , Tran K , Kang K , Hance IR , Nelson KE , Fraser CM
Ref : Journal of Bacteriology , 187 :2426 , 2005
PubMedID: 15774886
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594 , staep-lipas , staep-SE0011 , staep-SE0226 , staep-SE0386 , staep-SE0389 , staep-SE0424 , staep-SE0564 , staep-SE0714 , staep-SE0745 , staep-SE0980 , staep-SE1436 , staep-SE1460 , staep-SE1510 , staep-SE1780 , staep-SE1929 , staep-SERP2035 , staep-SE2050 , staep-SE2095 , staep-SE2213 , staep-SE2328

Title : Biochemical and molecular characterization of Staphylococcus simulans lipase - Sayari_2001_Biochimie_83_863
Author(s) : Sayari A , Agrebi N , Jaoua S , Gargouri Y
Ref : Biochimie , 83 :863 , 2001
PubMedID: 11698108
Gene_locus related to this paper: staau-lipas

Title : Staphylococcal lipases: biochemical and molecular characterization - Rosenstein_2000_Biochimie_82_1005
Author(s) : Rosenstein R , Gotz F
Ref : Biochimie , 82 :1005 , 2000
PubMedID: 11099797
Gene_locus related to this paper: staau-LIP , staau-lipas , staep-lipas , staep-SE0245 , stahy-lipas , stawa-GEHA , staxy-gehH , staxy-q2tpv1

Title : Staphylococcal lipases: molecular characterisation, secretion, and processing - Gotz_1998_Chem.Phys.Lipids_93_15
Author(s) : Gotz F , Verheij HM , Rosenstein R
Ref : Chemistry & Physic of Lipids , 93 :15 , 1998
PubMedID: 9720246
Gene_locus related to this paper: staau-LIP , staau-lipas , staep-lipas , staep-SE0245 , stahy-lipas , stawa-GEHA , staxy-gehH

Title : In vivo processing of Staphylococcus aureus lipase - Rollof_1992_J.Bacteriol_174_1844
Author(s) : Rollof J , Normark S
Ref : Journal of Bacteriology , 174 :1844 , 1992
PubMedID: 1548232
Gene_locus related to this paper: staau-lipas

Title : Lysogenic conversion of staphylococcal lipase is caused by insertion of the bacteriophage L54a genome into the lipase structural gene - Lee_1986_J.Bacteriol_166_385
Author(s) : Lee CY , Iandolo JJ
Ref : Journal of Bacteriology , 166 :385 , 1986
PubMedID: 3009394
Gene_locus related to this paper: staau-lipas

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Gene_locus related to this paper: staau-lipas

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Gene_locus related to this paper: staau-lipas