Staphylococcus aureus gene for lipase lip2, lipase 2, geh lipase. Glycerol ester hydrolase 2 gehB Staphylococcus simulans
Rosenstein R, Gotz F a review on Staphylococcal lipases. There is a long precursor which is cut to a 46kDa active form. Detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus depends on lipase 2. Lip2 detoxifies AFAs via esterification with cholesterol
Family : Bacterial_lip_FamI.6
Block : L
Position in NCBI Life Tree : Staphylococcus aureus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Firmicutes N E > Bacilli N E > Bacillales N E > Staphylococcaceae N E > Staphylococcus N E > Staphylococcus aureus N EGQNSPEKPTD KNTDNKQLIK DALQAPKTRS TTNAAADAKK VRPLKANQVQ PLNKYPVVFV HGFLGLVGDN APALYPNYWG GNKFKVIEEL RKQGYNVHQA SVSAFGSNYD RAVELYYYIK GGRVDYGAAH AAKYGHERYG KTYKGIMPNW EPGKKVHLVG HSMGGQTIRL MEEFLRNGNK EEIAYHKAHG GEISPLFTGG HNNMVASITT LATPHNGSQA ADKFGNTEAV RKIMFALNRF MGNKYSNIDL GLTQWGFKQL PNESYIDYIK RVSKSKIWTS DDNAAYDLTL DGSAKLNNMT SMNPNITYTT YTGVSSHTGP LGYENPDLGT FFLMATTSRI IGHDAREEWR KNDGVVPVIS SLHPSNQPFV NVTNDEPATR RGIWQVKPII QGWDHVDFIG VDFLDFKRKG AELANFYTGI INDLLRVEAT ESKGTQLKAS
Title : Staphylococcus aureus lipid factors modulate melanoma cell clustering and invasion - Giese_2024_Dis.Model.Mech_17_ |
Author(s) : Giese MA , Ramakrishnan G , Steenberge LH , Dovan JX , Sauer JD , Huttenlocher A |
Ref : Dis Model Mech , 17 : , 2024 |
Abstract : |
PubMedSearch : Giese_2024_Dis.Model.Mech_17_ |
PubMedID: 39284707 |
Gene_locus related to this paper: staau-lipas |
Title : Lipase-mediated detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus - Kengmo Tchoupa_2024_Commun.Biol_7_572 |
Author(s) : Kengmo Tchoupa A , Elsherbini AMA , Camus J , Fu X , Hu X , Ghaneme O , Seibert L , Lebtig M , Bocker MA , Horlbeck A , Lambidis SP , Schittek B , Kretschmer D , Lammerhofer M , Peschel A |
Ref : Commun Biol , 7 :572 , 2024 |
Abstract : |
PubMedSearch : Kengmo Tchoupa_2024_Commun.Biol_7_572 |
PubMedID: 38750133 |
Gene_locus related to this paper: staau-lipas |
Title : Functional characterization of Staphylococcus aureus lipase 2 (SAL2) as a collagen adhesin - Priyadharshini_2024_Biophys.Chem_317_107352 |
Author(s) : Priyadharshini T , Sankar S , Ponnuraj K |
Ref : Biophysical Chemistry , 317 :107352 , 2024 |
Abstract : |
PubMedSearch : Priyadharshini_2024_Biophys.Chem_317_107352 |
PubMedID: 39571274 |
Gene_locus related to this paper: staau-lipas |
Title : The Phospholipase A1 Activity of Glycerol Ester Hydrolase (Geh) Is Responsible for Extracellular 2-12(S)-Methyltetradecanoyl-Lysophosphatidylglycerol Production in Staphylococcus aureus - Subramanian_2023_mSphere__e0003123 |
Author(s) : Subramanian C , Frank MW , Yun MK , Rock CO |
Ref : mSphere , :e0003123 , 2023 |
Abstract : |
PubMedSearch : Subramanian_2023_mSphere__e0003123 |
PubMedID: 36976028 |
Gene_locus related to this paper: staau-lipas |
Title : Structure elucidation of Staphylococcus capitis lipase. Molecular dynamics simulations to investigate the effects of calcium and zinc ions on the structural stability - Rmili_2022_J.Biomol.Struct.Dyn__1 |
Author(s) : Rmili F , Frikha F , Chamkha M , Sayari A , Fendri A |
Ref : J Biomol Struct Dyn , :1 , 2022 |
Abstract : |
PubMedSearch : Rmili_2022_J.Biomol.Struct.Dyn__1 |
PubMedID: 36546696 |
Gene_locus related to this paper: staau-lipas |
Title : Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat - Kitadokoro_2020_Sci.Rep_10_5469 |
Author(s) : Kitadokoro K , Tanaka M , Hikima T , Okuno Y , Yamamoto M , Kamitani S |
Ref : Sci Rep , 10 :5469 , 2020 |
Abstract : |
PubMedSearch : Kitadokoro_2020_Sci.Rep_10_5469 |
PubMedID: 32214208 |
Gene_locus related to this paper: staau-lipas |
Title : Staphylococcus aureus Releases Proinflammatory Membrane Vesicles To Resist Antimicrobial Fatty Acids - Kengmo Tchoupa_2020_mSphere_5_e00804 |
Author(s) : Kengmo Tchoupa A , Peschel A |
Ref : mSphere , 5 :e00804 , 2020 |
Abstract : |
PubMedSearch : Kengmo Tchoupa_2020_mSphere_5_e00804 |
PubMedID: 32999082 |
Gene_locus related to this paper: staau-lipas |
Title : Bacterial lipolysis of immune-activating ligands promotes evasion of innate defenses - Chen_2019_Proc.Natl.Acad.Sci.U.S.A_116_3764 |
Author(s) : Chen X , Alonzo F, 3rd |
Ref : Proc Natl Acad Sci U S A , 116 :3764 , 2019 |
Abstract : |
PubMedSearch : Chen_2019_Proc.Natl.Acad.Sci.U.S.A_116_3764 |
PubMedID: 30755523 |
Gene_locus related to this paper: staau-LIP , staau-lipas |
Title : Staphylococcal (phospho)lipases promote biofilm formation and host cell invasion - Nguyen_2018_Int.J.Med.Microbiol_308_653 |
Author(s) : Nguyen MT , Luqman A , Bitschar K , Hertlein T , Dick J , Ohlsen K , Broker B , Schittek B , Gotz F |
Ref : Int J Med Microbiol , 308 :653 , 2018 |
Abstract : |
PubMedSearch : Nguyen_2018_Int.J.Med.Microbiol_308_653 |
PubMedID: 29203111 |
Gene_locus related to this paper: staau-LIP , staau-lipas , stawa-GEHA |
Title : Staphylococcus aureus lipase: purification, kinetic characterization, crystallization and crystallographic study - Tanaka_2018_Acta.Crystallogr.F.Struct.Biol.Commun_74_567 |
Author(s) : Tanaka M , Kamitani S , Kitadokoro K |
Ref : Acta Crystallographica F Struct Biol Commun , 74 :567 , 2018 |
Abstract : |
PubMedSearch : Tanaka_2018_Acta.Crystallogr.F.Struct.Biol.Commun_74_567 |
PubMedID: 30198889 |
Gene_locus related to this paper: staau-lipas |
Title : Role of Lipase from Community-Associated Methicillin-Resistant Staphylococcus aureus Strain USA300 in Hydrolyzing Triglycerides into Growth-Inhibitory Free Fatty Acids - Cadieux_2014_J.Bacteriol_196_4044 |
Author(s) : Cadieux B , Vijayakumaran V , Bernards MA , McGavin MJ , Heinrichs DE |
Ref : Journal of Bacteriology , 196 :4044 , 2014 |
Abstract : |
PubMedSearch : Cadieux_2014_J.Bacteriol_196_4044 |
PubMedID: 25225262 |
Gene_locus related to this paper: staau-lipas |
Title : Functional characterization of lipase in the pathogenesis of Staphylococcus aureus - Hu_2012_Biochem.Biophys.Res.Commun_419_617 |
Author(s) : Hu C , Xiong N , Zhang Y , Rayner S , Chen S |
Ref : Biochemical & Biophysical Research Communications , 419 :617 , 2012 |
Abstract : |
PubMedSearch : Hu_2012_Biochem.Biophys.Res.Commun_419_617 |
PubMedID: 22369949 |
Gene_locus related to this paper: staau-lipas |
Title : Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis - Schijffelen_2010_BMC.Genomics_11_376 |
Author(s) : Schijffelen MJ , Boel CH , van Strijp JA , Fluit AC |
Ref : BMC Genomics , 11 :376 , 2010 |
Abstract : |
PubMedSearch : Schijffelen_2010_BMC.Genomics_11_376 |
PubMedID: 20546576 |
Gene_locus related to this paper: staau-c8mfq3 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594 |
Title : Complete genome sequence of Staphylococcus aureus strain JKD6159, a unique Australian clone of ST93-IV community methicillin-resistant Staphylococcus aureus - Chua_2010_J.Bacteriol_192_5556 |
Author(s) : Chua K , Seemann T , Harrison PF , Davies JK , Coutts SJ , Chen H , Haring V , Moore R , Howden BP , Stinear TP |
Ref : Journal of Bacteriology , 192 :5556 , 2010 |
Abstract : |
PubMedSearch : Chua_2010_J.Bacteriol_192_5556 |
PubMedID: 20729356 |
Gene_locus related to this paper: staau-c8mfq3 , staau-d2feb3 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2422 , staau-SAV0321 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594 |
Title : Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation - Guinane_2010_Genome.Biol.Evol_2_454 |
Author(s) : Guinane CM , Ben Zakour NL , Tormo-Mas MA , Weinert LA , Lowder BV , Cartwright RA , Smyth DS , Smyth CJ , Lindsay JA , Gould KA , Witney A , Hinds J , Bollback JP , Rambaut A , Penades JR , Fitzgerald JR |
Ref : Genome Biol Evol , 2 :454 , 2010 |
Abstract : |
PubMedSearch : Guinane_2010_Genome.Biol.Evol_2_454 |
PubMedID: 20624747 |
Gene_locus related to this paper: staau-d2feb3 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594 |
Title : Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus - Lowder_2009_Proc.Natl.Acad.Sci.U.S.A_106_19545 |
Author(s) : Lowder BV , Guinane CM , Ben Zakour NL , Weinert LA , Conway-Morris A , Cartwright RA , Simpson AJ , Rambaut A , Nubel U , Fitzgerald JR |
Ref : Proc Natl Acad Sci U S A , 106 :19545 , 2009 |
Abstract : |
PubMedSearch : Lowder_2009_Proc.Natl.Acad.Sci.U.S.A_106_19545 |
PubMedID: 19884497 |
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594 |
Title : Interaction of sortase A and lipase 2 in the inhibition of Staphylococcus aureus biofilm formation - Xiong_2009_Arch.Microbiol_191_879 |
Author(s) : Xiong N , Hu C , Zhang Y , Chen S |
Ref : Arch Microbiol , 191 :879 , 2009 |
Abstract : |
PubMedSearch : Xiong_2009_Arch.Microbiol_191_879 |
PubMedID: 19838678 |
Gene_locus related to this paper: staau-lipas |
Title : Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance - Neoh_2008_Antimicrob.Agents.Chemother_52_45 |
Author(s) : Neoh HM , Cui L , Yuzawa H , Takeuchi F , Matsuo M , Hiramatsu K |
Ref : Antimicrobial Agents & Chemotherapy , 52 :45 , 2008 |
Abstract : |
PubMedSearch : Neoh_2008_Antimicrob.Agents.Chemother_52_45 |
PubMedID: 17954695 |
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594 |
Title : Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands - Baba_2008_J.Bacteriol_190_300 |
Author(s) : Baba T , Bae T , Schneewind O , Takeuchi F , Hiramatsu K |
Ref : Journal of Bacteriology , 190 :300 , 2008 |
Abstract : |
PubMedSearch : Baba_2008_J.Bacteriol_190_300 |
PubMedID: 17951380 |
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2484 , staau-SAV2594 |
Title : 3-D structure modelling of the Staphylococcus simulans lipase: conformational changes, substrate specificity and novel structural features - Frikha_2008_FEMS.Microbiol.Lett_286_207 |
Author(s) : Frikha F , Ladjimi M , Gargouri Y , Miled N |
Ref : FEMS Microbiology Letters , 286 :207 , 2008 |
Abstract : |
PubMedSearch : Frikha_2008_FEMS.Microbiol.Lett_286_207 |
PubMedID: 18662315 |
Gene_locus related to this paper: staau-lipas |
Title : Genome sequencing and analysis reveals possible determinants of Staphylococcus aureus nasal carriage - Sivaraman_2008_BMC.Genomics_9_433 |
Author(s) : Sivaraman K , Venkataraman N , Tsai J , Dewell S , Cole AM |
Ref : BMC Genomics , 9 :433 , 2008 |
Abstract : |
PubMedSearch : Sivaraman_2008_BMC.Genomics_9_433 |
PubMedID: 18808706 |
Gene_locus related to this paper: staau-lipas , staau-MW0741 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594 |
Title : Molecular correlates of host specialization in Staphylococcus aureus - Herron-Olson_2007_PLoS.One_2_e1120 |
Author(s) : Herron-Olson L , Fitzgerald JR , Musser JM , Kapur V |
Ref : PLoS ONE , 2 :e1120 , 2007 |
Abstract : |
PubMedSearch : Herron-Olson_2007_PLoS.One_2_e1120 |
PubMedID: 17971880 |
Gene_locus related to this paper: staau-LIP , staau-lipas , staau-MW0741 , staau-SAV0321 , staau-SAV0457 , staau-SAV1793 |
Title : Importance of the residue Asp 290 on chain length selectivity and catalytic efficiency of recombinant Staphylococcus simulans lipase expressed in E. coli - Sayari_2007_Mol.Biotechnol_36_14 |
Author(s) : Sayari A , Mosbah H , Gargouri Y |
Ref : Mol Biotechnol , 36 :14 , 2007 |
Abstract : |
PubMedSearch : Sayari_2007_Mol.Biotechnol_36_14 |
PubMedID: 17827533 |
Gene_locus related to this paper: staau-lipas |
Title : Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus - Diep_2006_Lancet_367_731 |
Author(s) : Diep BA , Gill SR , Chang RF , Phan TH , Chen JH , Davidson MG , Lin F , Lin J , Carleton HA , Mongodin EF , Sensabaugh GF , Perdreau-Remington F |
Ref : Lancet , 367 :731 , 2006 |
Abstract : |
PubMedSearch : Diep_2006_Lancet_367_731 |
PubMedID: 16517273 |
Gene_locus related to this paper: staa3-q2fkj0 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 , staau-SAV2594 |
Title : Genome and virulence determinants of high virulence community-acquired MRSA - Baba_2002_Lancet_359_1819 |
Author(s) : Baba T , Takeuchi F , Kuroda M , Yuzawa H , Aoki K , Oguchi A , Nagai Y , Iwama N , Asano K , Naimi T , Kuroda H , Cui L , Yamamoto K , Hiramatsu K |
Ref : Lancet , 359 :1819 , 2002 |
Abstract : |
PubMedSearch : Baba_2002_Lancet_359_1819 |
PubMedID: 12044378 |
Gene_locus related to this paper: staau-d2uin3 , staau-LIP , staau-lipas , staau-MW0741 , staau-MW2456 , staau-q6gfm6 , staau-SA0011 , staau-SA0569 , staau-SA0572 , staau-SA0897 , staau-SA1143 , staau-SA2240 , staau-SA2306 , staau-SA2367 , staau-SA2422 , staau-SAV0321 , staau-SAV0446 , staau-SAV0457 , staau-SAV0655 , staau-SAV1014 , staau-SAV1765 , staau-SAV1793 , staau-SAV2188 , staau-SAV2350 |
Title : Biochemical and molecular characterization of Staphylococcus simulans lipase - Sayari_2001_Biochimie_83_863 |
Author(s) : Sayari A , Agrebi N , Jaoua S , Gargouri Y |
Ref : Biochimie , 83 :863 , 2001 |
Abstract : |
PubMedSearch : Sayari_2001_Biochimie_83_863 |
PubMedID: 11698108 |
Gene_locus related to this paper: staau-lipas |
Title : Staphylococcal lipases: biochemical and molecular characterization - Rosenstein_2000_Biochimie_82_1005 |
Author(s) : Rosenstein R , Gotz F |
Ref : Biochimie , 82 :1005 , 2000 |
Abstract : |
PubMedSearch : Rosenstein_2000_Biochimie_82_1005 |
PubMedID: 11099797 |
Gene_locus related to this paper: staau-LIP , staau-lipas , staep-lipas , staep-SE0245 , stahy-lipas , stawa-GEHA , staxy-gehH , staxy-q2tpv1 |
Title : Staphylococcal lipases: molecular characterisation, secretion, and processing - Gotz_1998_Chem.Phys.Lipids_93_15 |
Author(s) : Gotz F , Verheij HM , Rosenstein R |
Ref : Chemistry & Physic of Lipids , 93 :15 , 1998 |
Abstract : |
PubMedSearch : Gotz_1998_Chem.Phys.Lipids_93_15 |
PubMedID: 9720246 |
Gene_locus related to this paper: staau-LIP , staau-lipas , staep-lipas , staep-SE0245 , stahy-lipas , stawa-GEHA , staxy-gehH |
Title : In vivo processing of Staphylococcus aureus lipase - Rollof_1992_J.Bacteriol_174_1844 |
Author(s) : Rollof J , Normark S |
Ref : Journal of Bacteriology , 174 :1844 , 1992 |
Abstract : |
PubMedSearch : Rollof_1992_J.Bacteriol_174_1844 |
PubMedID: 1548232 |
Gene_locus related to this paper: staau-lipas |
Title : Lysogenic conversion of staphylococcal lipase is caused by insertion of the bacteriophage L54a genome into the lipase structural gene - Lee_1986_J.Bacteriol_166_385 |
Author(s) : Lee CY , Iandolo JJ |
Ref : Journal of Bacteriology , 166 :385 , 1986 |
Abstract : |
PubMedSearch : Lee_1986_J.Bacteriol_166_385 |
PubMedID: 3009394 |
Gene_locus related to this paper: staau-lipas |