Phenothiazine

Tricyclic amine-containing compound || Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI)

General

Type : Phenothiazine, Not A\/B H target, Multitarget, Drug, Sulfur Compound

Chemical_Nomenclature : Phenothiazine

Canonical SMILES : C1=CC=C2C(=C1)NC3=CC=CC=C3S2

InChI : InChI=1S\/C12H9NS\/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11\/h1-8,13H

InChIKey : WJFKNYWRSNBZNX-UHFFFAOYSA-N

Other name(s) :


MW : 199.3

Formula : C12H9NS

CAS_number : 92-84-2

PubChem : 7108

UniChem : WJFKNYWRSNBZNX-UHFFFAOYSA-N

Wikipedia : Phenothiazine

Target

Families : Phenothiazine ligand of proteins in family
ACHE

References (1)

Title : Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase - Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97
Author(s) : Singh AK , Spassova D
Ref : Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology , 119 :97 , 1998
Abstract :
PubMedSearch : Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97
PubMedID: 9568379