PiB
Carbon C 11 Pittsburgh Compound B is a radioconjugate composed of the beta-amyloid binding agent Pittsburgh compound B (PiB), a derivative of the amyloid-binding dye thioflavin T (ThT), that is conjugated to the radioisotope carbon C11, with potential amyloid imaging activity upon positron emission tomography (PET)
General
Type : Benzothiazol, Multitarget, Not AlphaBeta Hydrolase target, PET probe
Chemical_Nomenclature : 2-[4-((111C)methylamino)phenyl]-1,3-benzothiazol-6-ol || 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol
Canonical SMILES : [11CH3]NC1=CC=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O || CNC1=CC=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O
InChI : InChI=1S\/C14H12N2OS\/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14\/h2-8,15,17H,1H3\/i1-1 || InChI=1S\/C14H12N2OS\/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14\/h2-8,15,17H,1H3
InChIKey : ZQAQXZBSGZUUNL-BJUDXGSMSA-N || ZQAQXZBSGZUUNL-UHFFFAOYSA-N
Other name(s) : Pittsburgh Compound B || C-11 PiB || 11C-PIB || (N-methyl-(11c))2-(4'-methylaminophenyl)-6-hydroxybenzothiazole || Pittsburgh compound b c-11 || 7P55415B0R || [11C]PIB || 6-OH-BTA-1 || PIB benzothiazole || RefChem:909248 || 2-(4'-(Methylamino)phenyl)-6-hydroxybenzothiazole || Pittsburgh compound B unlabelled || CHEMBL207456 || SCHEMBL2055285 || SCHEMBL29360193 || [11C]-6-OH-BTA-1 || DB15161 || RefChem:908027
MW : 255.33 || 256.32
Formula : C14H12N2OS
CAS_number : 566170-04-5
UniChem : ZQAQXZBSGZUUNL-BJUDXGSMSA-N, ZQAQXZBSGZUUNL-UHFFFAOYSA-N
Target
References (14)
| Title : Potential Off-Target Interaction of the Amyloid PET Imaging Tracer PiB with Acetylcholinesterase - Granzotto_2025_ACS.Omega_10_48544 |
| Author(s) : Granzotto A , Fullone R , Miccoli L , Bomba M , Di Marzio C , Delli Pizzi S , Floresta G , Sensi SL |
| Ref : ACS Omega , 10 :48544 , 2025 |
| Abstract : |
| PubMedSearch : Granzotto_2025_ACS.Omega_10_48544 |
| PubMedID: 41141733 |
| Title : The Effect of Cholinesterase Inhibitors on Neurodegeneration in Individuals with Amnestic Mild Cognitive Impairment - Byeon_2025_Clin.Psychopharmacol.Neurosci_23_256 |
| Author(s) : Byeon G , Byun MS , Yi D , Ahn H , Jung G , Sohn BK , Jung JH , Chang YY , Kim K , Choi H , Kim YH , Kim YK , Kang KM , Sohn CH , Lee DY |
| Ref : Clin Psychopharmacol Neurosci , 23 :256 , 2025 |
| Abstract : |
| PubMedSearch : Byeon_2025_Clin.Psychopharmacol.Neurosci_23_256 |
| PubMedID: 40223260 |
| Title : Apathy rating scores and beta-amyloidopathy in patients with Parkinson disease at risk for cognitive decline - Zhou_2020_Neurology_94_e376 |
| Author(s) : Zhou Z , Muller M , Kanel P , Chua J , Kotagal V , Kaufer DI , Albin RL , Frey KA , Bohnen NI |
| Ref : Neurology , 94 :e376 , 2020 |
| Abstract : |
| PubMedSearch : Zhou_2020_Neurology_94_e376 |
| PubMedID: 31732566 |
| Title : Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Abeta Fibril Assembly - Thamban_2019_Molecules_25_ |
| Author(s) : Thamban Chandrika N , Fosso MY , Tsodikov OV , LeVine Iii H , Garneau-Tsodikova S |
| Ref : Molecules , 25 : , 2019 |
| Abstract : |
| PubMedSearch : Thamban_2019_Molecules_25_ |
| PubMedID: 31878304 |
| Title : Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals - Han_2018_Neurobiol.Aging_73_21 |
| Author(s) : Han SH , Park JC , Byun MS , Yi D , Lee JH , Lee DY , Mook-Jung I |
| Ref : Neurobiology of Aging , 73 :21 , 2018 |
| Abstract : |
| PubMedSearch : Han_2018_Neurobiol.Aging_73_21 |
| PubMedID: 30316049 |
| Title : Striatal and Cortical beta-Amyloidopathy and Cognition in Parkinson's Disease - Shah_2016_Mov.Disord_31_111 |
| Author(s) : Shah N , Frey KA , M LTMM , Petrou M , Kotagal V , Koeppe RA , Scott PJ , Albin RL , Bohnen NI |
| Ref : Movement Disorders , 31 :111 , 2016 |
| Abstract : |
| PubMedSearch : Shah_2016_Mov.Disord_31_111 |
| PubMedID: 26380951 |
| Title : Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease - Kerbler_2015_Neuroimage.Clin_7_105 |
| Author(s) : Kerbler GM , Fripp J , Rowe CC , Villemagne VL , Salvado O , Rose S , Coulson EJ |
| Ref : Neuroimage Clin , 7 :105 , 2015 |
| Abstract : |
| PubMedSearch : Kerbler_2015_Neuroimage.Clin_7_105 |
| PubMedID: 25610772 |
| Title : Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue - Ni_2013_Brain_136_2217 |
| Author(s) : Ni R , Gillberg PG , Bergfors A , Marutle A , Nordberg A |
| Ref : Brain , 136 :2217 , 2013 |
| Abstract : |
| PubMedSearch : Ni_2013_Brain_136_2217 |
| PubMedID: 23757761 |
| Title : Modulation of alpha7 Nicotinic Acetylcholine Receptor and Fibrillar Amyloid-beta Interactions in Alzheimer's Disease Brain - Ni_2013_J.Alzheimers.Dis_33_841 |
| Author(s) : Ni R , Marutle A , Nordberg A |
| Ref : J Alzheimers Dis , 33 :841 , 2013 |
| Abstract : |
| PubMedSearch : Ni_2013_J.Alzheimers.Dis_33_841 |
| PubMedID: 23042213 |
| Title : Alzheimer's disease: early diagnosis and treatment - Chu_2012_Hong.Kong.Med.J_18_228 |
| Author(s) : Chu LW |
| Ref : Hong Kong Med J , 18 :228 , 2012 |
| Abstract : |
| PubMedSearch : Chu_2012_Hong.Kong.Med.J_18_228 |
| PubMedID: 22665688 |
| Title : Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies - Graff-Radford_2012_Brain_135_2470 |
| Author(s) : Graff-Radford J , Boeve BF , Pedraza O , Ferman TJ , Przybelski S , Lesnick TG , Vemuri P , Senjem ML , Smith GE , Knopman DS , Lowe V , Jack CR, Jr. , Petersen RC , Kantarci K |
| Ref : Brain , 135 :2470 , 2012 |
| Abstract : |
| PubMedSearch : Graff-Radford_2012_Brain_135_2470 |
| PubMedID: 22810436 |
| Title : Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo - Darreh-Shori_2011_Neurobiol.Aging_32_2320 e15 |
| Author(s) : Darreh-Shori T , Forsberg A , Modiri N , Andreasen N , Blennow K , Kamil C , Ahmed H , Almkvist O , Langstrom B , Nordberg A |
| Ref : Neurobiology of Aging , 32 :2320 e15 , 2011 |
| Abstract : |
| PubMedSearch : Darreh-Shori_2011_Neurobiol.Aging_32_2320 e15 |
| PubMedID: 20538374 |
| Title : Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease - Kadir_2011_Brain_134_301 |
| Author(s) : Kadir A , Marutle A , Gonzalez D , Scholl M , Almkvist O , Mousavi M , Mustafiz T , Darreh-Shori T , Nennesmo I , Nordberg A |
| Ref : Brain , 134 :301 , 2011 |
| Abstract : |
| PubMedSearch : Kadir_2011_Brain_134_301 |
| PubMedID: 21149866 |
| Title : Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study - Degerman_2010_Dement.Geriatr.Cogn.Disord_29_204 |
| Author(s) : Degerman Gunnarsson M , Lindau M , Wall A , Blennow K , Darreh-Shori T , Basu S , Nordberg A , Larsson A , Lannfelt L , Basun H , Kilander L |
| Ref : Dementia & Geriatric Cognitive Disorders , 29 :204 , 2010 |
| Abstract : |
| PubMedSearch : Degerman_2010_Dement.Geriatr.Cogn.Disord_29_204 |
| PubMedID: 20332638 |