PET probe

General

Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. Radionuclides used in PET scanning are typically isotopes with short half-lives such as carbon-11 (20 min), nitrogen-13 (10 min), oxygen-15 (2 min), fluorine-18 (110 min), gallium-68 (~67 min), zirconium-89 (78.41 hours), or rubidium-82(1.27 min). These radionuclides are incorporated either into compounds
Inhibitor Main targeted enzyme families Type Structure
PNT6555 DPP4N_Peptidase_S9 PET probe Peptide
FNDP Epoxide_hydrolase PET probe Carboxamide
JZP-MA-11 ABHD6-Lip Sulfur Compound PET probe Thiadiazol Piperidine Carbamate
SCHEMBL22462761 Monoglyceridelipase_lysophospholip PET probe Trifluoro Urea derivative Azetidin
FEPAD Monoglyceridelipase_lysophospholip Piperazine Azetidin Trifluoro Thiazolidine Sulfur Compound PET probe
YH149 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe
123I-PIP BCHE Carbamate PET probe
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
Tetracyclic-carbamate-cp8 BCHE PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
CHEMBL4454960-PET BCHE PET probe Carbamate
VXS BCHE ACHE PET probe Organophosphate Derivative of Paraoxon Derivative of VX pNP
T-401 Monoglyceridelipase_lysophospholip Pyrrolidine Piperazine PET probe Sulfur Compound
FAPI-04 DPP4N_Peptidase_S9 Piperazine Quinoline PET probe Carboxamide tert-Butyl tert-Butyloxycarbonyl
PF-06795071 Monoglyceridelipase_lysophospholip Trifluoro Carbamate PET probe Pyrazole Azabicyclo
5DYW-5hf-C11 BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe Naphthalen
5DYW-5hf-F BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe
QST-0837 Monoglyceridelipase_lysophospholip PET probe Carbamate Trifluoro Azetidin Pyrazole
64D Monoglyceridelipase_lysophospholip Piperidine PET probe Sulfonyl Sulfur Compound
Pyridophen-10 ACHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not A\/B H target PET probe
[11C]N-methyl-tacrine ACHE Acridine Derivative of Tacrine PET probe