Pyrazol-dioxolo-indolo-oxazino-isoquinoline-carboxylate-Cpd8
AChE IC50 0.29 microM
General
Type : Pyrazole, Indole, Oxazine, Isoquinoline, Carboxylate
Chemical_Nomenclature : Ethyl 2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1,4,7,12b-tetrahydro-6H-[1,3]dioxolo[4,5-g]indolo[4,5:5,6][1,3]oxazino[2,3-a]isoquinoline-3-carboxylate
Canonical SMILES : C1=C7C(=CC2=C1CCN4C2OC3=CC=C5C(=C3C4)C(=C([N]5C6=C[N](N=C6)CCC)C)C(=O)OCC)OCO7
InChI : InChI=1S\/C29H30N4O5\/c1-4-9-32-14-19(13-30-32)33-17(3)26(29(34)35-5-2)27-21-15-31-10-8-18-11-24-25(37-16-36-24)12-20(18)28(31)38-23(21)7-6-22(27)33\/h6-7,11-14,28H,4-5,8-10,15-16H2,1-3H3
InChIKey : ADWJEQFWSYOVHJ-UHFFFAOYSA-N
Other name(s) : Compound 8
Target
Families : Pyrazol-dioxolo-indolo-oxazino-isoquinoline-carboxylate-Cpd8 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Structure-based identification of novel indole-fused polycyclic derivatives as potent acetylcholinesterase inhibitors - Chen_2026_Bioorg.Med.Chem_142_118765 |
| Author(s) : Chen W , Zhan K , Xu C , Sun S , Yang X , Lei H |
| Ref : Bioorganic & Medicinal Chemistry , 142 :118765 , 2026 |
| Abstract : |
| PubMedSearch : Chen_2026_Bioorg.Med.Chem_142_118765 |
| PubMedID: 42561776 |