Isoquinoline

General

Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
BuChE-IN-TM-10 BCHE Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor
(S)Aporphine-N-benzylpyridinium Isoquinoline Alkaloid
(Isoquinolin-1-ylsulfanyl)-acetic-acid Pectinacetylesterase-Notum Fragment inhibitor of Notum Isoquinoline Quinoline Sulfur Compound
VL1-8MH Haloalkane_dehalogenase-HLD2 Fluorescent Probe HaloTag-ligand Isoquinoline Quinoline
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
4-Oxo-beta-Lactam-91-sub DPP4N_Peptidase_S9 Isoquinoline beta-Lactam Benzodioxo Azetidin
4-Oxo-beta-Lactam-91 DPP4N_Peptidase_S9 Isoquinoline beta-Lactam Benzodioxo
CHEMBL2152538 Not A\/B H target Isoquinoline Quinazoline
Palmatine Natural Alkaloid Not A\/B H target Isoquinoline
Berberine ACHE BCHE Natural Alkaloid Not A\/B H target Isoquinoline Benzodioxo
Tetracyclic-carbamate-cp8 BCHE PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
Tetracyclic-carbamate-UW-MD-95 BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
Isoquinoline-45-JV8 Pectinacetylesterase-Notum Isoquinoline
Tetracyclic-carbamate-photoswitch-azo BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Photoswitch
TAK-294 DPP4N_Peptidase_S9 Isoquinoline
Tetrahydroisoquinoline-derivative DPP4N_Peptidase_S9 Isoquinoline Carboxamide
Atracurium BCHE Not A\/B H target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate
Naftalofos ACHE Insecticide Isoquinoline Organophosphate
Jatrorrhizine Natural Alkaloid Not A\/B H target Isoquinoline
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not A\/B H target
Tryptophan-tetrahydroisoquinoline-Cpd7g BCHE Quinoline Derivative of Tryptophan Isoquinoline
Quilostigmine ACHE Derivative of physostigmine-eserine Carbamate Isoquinoline Indole
Doxacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not A\/B H target
Cisatracurium BCHE Propionate Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not A\/B H target