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Isoquinoline

General

Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
3-allylrhodanine-hydroxyethoxybenzylidene-hydroisoquinoline-Cpd11 BCHE ACHE Thiazolidine Thiazole Sulfur Compound Isoquinoline
3-allylrhodanine-hydroxymethoxybenzylidene-hydroisoquinoline-Cpd6 BCHE ACHE Thiazolidine Thiazole Sulfur Compound Isoquinoline
CHEMBL4797670 Isoquinoline Alkaloid Quinoline
CHEMBL4085222 BCHE Derivative of Donepezil Piperidine Quinoline Feruloyl Isoquinoline Benzylpiperidine
Corydaline ACHE Alkaloid Natural Quinoline Isoquinoline
BuChE-IN-TM-10 BCHE Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor
(S)Aporphine-N-benzylpyridinium ACHE Isoquinoline Pyridine Alkaloid Organochlorine
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline Isoquinoline
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Isoquinoline Cyclobutyl Benzylpiperidine Derivative of Donepezil Organochlorine
Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4f Piperidine Sulfur Compound Sulfonamide Carboxamide Multitarget Isoquinoline Organochlorine
(Isoquinolin-1-ylsulfanyl)-acetic-acid Pectinacetylesterase-Notum Fragment inhibitor of Notum Isoquinoline Quinoline Sulfur Compound
VL1-8MH Haloalkane_dehalogenase-HLD2 Fluorescent Probe HaloTag-ligand Isoquinoline Quinoline
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
4-Oxo-beta-Lactam-91-sub DPP4N_Peptidase_S9 Isoquinoline beta-Lactam Azetidin
4-Oxo-beta-Lactam-91 DPP4N_Peptidase_S9 Isoquinoline beta-Lactam
CHEMBL2152538 Not AlphaBeta Hydrolase target Isoquinoline Quinazoline Leaving group
Columbamine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant Derivative of berberine
Tetracyclic-carbamate-cp8 BCHE PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
Tetracyclic-carbamate-UW-MD-95 BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
Isoquinoline-45-JV8 Pectinacetylesterase-Notum Isoquinoline
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
Tetracyclic-carbamate-photoswitch-azo BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Photoswitch
TAK-294 DPP4N_Peptidase_S9 Isoquinoline
Tetrahydroisoquinoline-derivative DPP4N_Peptidase_S9 Isoquinoline Carboxamide
Atracurium BCHE Not AlphaBeta Hydrolase target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate Dimethoxyphenyl
Naftalofos ACHE Insecticide Isoquinoline Organophosphate
Jatrorrhizine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Tryptophan-tetrahydroisoquinoline-Cpd7g BCHE Quinoline Derivative of Tryptophan Isoquinoline
Quilostigmine ACHE Derivative of physostigmine-eserine Stigmine Carbamate Isoquinoline Indole
Doxacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium BCHE Propionate Dimethoxyphenyl Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target
3-allylrhodanine-hydroxyethoxybenzylidene-hydroisoquinoline-Cpd11 BCHE ACHE Thiazolidine Thiazole Sulfur compound Isoquinoline
3-allylrhodanine-hydroxymethoxybenzylidene-hydroisoquinoline-Cpd6 BCHE ACHE Thiazolidine Thiazole Sulfur compound Isoquinoline
CHEMBL4797670 Isoquinoline Alkaloid Quinoline
CHEMBL4085222 BCHE Derivative of Donepezil Piperidine Quinoline Feruloyl Isoquinoline Benzylpiperidine
Corydaline ACHE Alkaloid Natural Quinoline Isoquinoline
BuChE-IN-TM-10 BCHE Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor
(S)Aporphine-N-benzylpyridinium ACHE Isoquinoline Pyridine Alkaloid Organochlorine
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline Isoquinoline
J8-A34 ACHE Piperidine Sulfur compound Sulfonamide Quinoline Isoquinoline Cyclobutyl Benzylpiperidine Derivative of Donepezil Organochlorine
Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4f Piperidine Sulfur compound Sulfonamide Carboxamide Multitarget Isoquinoline Organochlorine
(Isoquinolin-1-ylsulfanyl)-acetic-acid Pectinacetylesterase-Notum Fragment inhibitor of Notum Isoquinoline Quinoline Sulfur compound
VL1-8MH Haloalkane_dehalogenase-HLD2 Fluorescent Probe HaloTag-ligand Isoquinoline Quinoline
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
4-Oxo-beta-Lactam-91-sub DPP4N_Peptidase_S9 Isoquinoline beta-Lactam Azetidin
4-Oxo-beta-Lactam-91 DPP4N_Peptidase_S9 Isoquinoline beta-Lactam
CHEMBL2152538 Not AlphaBeta Hydrolase target Isoquinoline Quinazoline Leaving group
Columbamine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant Derivative of berberine Ammonium
Tetracyclic-carbamate-cp8 BCHE PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
Tetracyclic-carbamate-UW-MD-95 BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
Isoquinoline-45-JV8 Pectinacetylesterase-Notum Isoquinoline
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
Tetracyclic-carbamate-photoswitch-azo BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Photoswitch
TAK-294 DPP4N_Peptidase_S9 Isoquinoline
Tetrahydroisoquinoline-derivative DPP4N_Peptidase_S9 Isoquinoline Carboxamide
Atracurium BCHE Not AlphaBeta Hydrolase target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate Dimethoxyphenyl
Naftalofos ACHE Insecticide Isoquinoline Organophosphate
Jatrorrhizine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Tryptophan-tetrahydroisoquinoline-Cpd7g BCHE Quinoline Derivative of Tryptophan Isoquinoline
Quilostigmine ACHE Derivative of physostigmine-eserine Stigmine Carbamate Isoquinoline Indole
Doxacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium BCHE Propionate Dimethoxyphenyl Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target
3-allylrhodanine-hydroxyethoxybenzylidene-hydroisoquinoline-Cpd11 BCHE ACHE Thiazolidine Thiazole Sulfur compound Isoquinoline
3-allylrhodanine-hydroxymethoxybenzylidene-hydroisoquinoline-Cpd6 BCHE ACHE Thiazolidine Thiazole Sulfur compound Isoquinoline
CHEMBL4797670 Isoquinoline Alkaloid Quinoline
CHEMBL4085222 BCHE Derivative of Donepezil Piperidine Quinoline Feruloyl Isoquinoline Benzylpiperidine
Corydaline ACHE Alkaloid Natural Quinoline Isoquinoline
BuChE-IN-TM-10 BCHE Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor
(S)Aporphine-N-benzylpyridinium ACHE Isoquinoline Pyridine Alkaloid Organochlorine
O-Methyl-Dauracine DPP4N_Peptidase_S9 Alkaloid Natural Quinoline Isoquinoline
J8-A34 ACHE Piperidine Sulfur compound Sulfonamide Quinoline Isoquinoline Cyclobutyl Benzylpiperidine Derivative of Donepezil Organochlorine
Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4f Piperidine Sulfur compound Sulfonamide Carboxamide Multitarget Isoquinoline Organochlorine
(Isoquinolin-1-ylsulfanyl)-acetic-acid Pectinacetylesterase-Notum Fragment inhibitor of Notum Isoquinoline Quinoline Sulfur compound
VL1-8MH Haloalkane_dehalogenase-HLD2 Fluorescent Probe HaloTag-ligand Isoquinoline Quinoline
Emetine Hydrolase_RBBP9_YdeN Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
4-Oxo-beta-Lactam-91-sub DPP4N_Peptidase_S9 Isoquinoline beta-Lactam Azetidin
4-Oxo-beta-Lactam-91 DPP4N_Peptidase_S9 Isoquinoline beta-Lactam
CHEMBL2152538 Not AlphaBeta Hydrolase target Isoquinoline Quinazoline Leaving group
Columbamine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant Derivative of berberine Ammonium
Tetracyclic-carbamate-cp8 BCHE PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Tetracyclic-carbamate-melatonine-3c BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
Tetracyclic-carbamate-UW-MD-95 BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
CHEMBL4454960 BCHE Morpholine Isoquinoline Carbamate Quinazoline
Isoquinoline-45-JV8 Pectinacetylesterase-Notum Isoquinoline
sEH-inhibitor-19 Epoxide_hydrolase Natural Alkaloid Isoquinoline Trifluoro Urea derivative Derivative of berberine
Tetracyclic-carbamate-photoswitch-azo BCHE Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Photoswitch
TAK-294 DPP4N_Peptidase_S9 Isoquinoline
Tetrahydroisoquinoline-derivative DPP4N_Peptidase_S9 Isoquinoline Carboxamide
Atracurium BCHE Not AlphaBeta Hydrolase target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate Dimethoxyphenyl
Naftalofos ACHE Insecticide Isoquinoline Organophosphate
Jatrorrhizine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Derivative of berberine
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
Tryptophan-tetrahydroisoquinoline-Cpd7g BCHE Quinoline Derivative of Tryptophan Isoquinoline
Quilostigmine ACHE Derivative of physostigmine-eserine Stigmine Carbamate Isoquinoline Indole
Doxacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium BCHE Propionate Dimethoxyphenyl Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target