Isoquinoline

General

Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. Building block for many inhibitors of enzymes

Inhibitor	Main targeted enzyme families	Type
BuChE-IN-TM-10	BCHE	Feruloyl Hydroxycinnamic-ester Multitarget Isoquinoline Monoamine-oxidase-inhibitor
(S)Aporphine-N-benzylpyridinium	ACHE	Isoquinoline Pyridine Alkaloid
(Isoquinolin-1-ylsulfanyl)-acetic-acid	Pectinacetylesterase-Notum	Fragment inhibitor of Notum Isoquinoline Quinoline Sulfur Compound
VL1-8MH	Haloalkane_dehalogenase-HLD2	Fluorescent Probe HaloTag-ligand Isoquinoline Quinoline
Emetine	Hydrolase_RBBP9_YdeN	Natural Alkaloid Drug Isoquinoline Quinoline Quinolizine
4-Oxo-beta-Lactam-91-sub	DPP4N_Peptidase_S9	Isoquinoline beta-Lactam Azetidin
4-Oxo-beta-Lactam-91	DPP4N_Peptidase_S9	Isoquinoline beta-Lactam
CHEMBL2152538		Not A\/B H target Isoquinoline Quinazoline Leaving group
Palmatine	ACHE	Natural Alkaloid Not A\/B H target Isoquinoline
Berberine	ACHE BCHE	Natural Alkaloid Not A\/B H target Isoquinoline Benzodioxo Antioxidant
Tetracyclic-carbamate-cp8	BCHE	PET probe Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
Tetracyclic-carbamate-melatonine-3c	BCHE	Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Derivative of Tryptamine Indole Alkyl linked bis-ligand
Tetracyclic-carbamate-ferulicacid-4a	BCHE	Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Feruloyl Antioxidant Alkyl linked bis-ligand
Tetracyclic-carbamate-UW-MD-95	BCHE	Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline
CHEMBL4454960	BCHE	Morpholine Isoquinoline Carbamate Quinazoline
Isoquinoline-45-JV8	Pectinacetylesterase-Notum	Isoquinoline
Tetracyclic-carbamate-photoswitch-azo	BCHE	Carbamate Natural_modified Derivative of Evodiamine Isoquinoline Quinazoline Photoswitch
TAK-294	DPP4N_Peptidase_S9	Isoquinoline
Tetrahydroisoquinoline-derivative	DPP4N_Peptidase_S9	Isoquinoline Carboxamide
Atracurium	BCHE	Not A\/B H target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate
Naftalofos	ACHE	Insecticide Isoquinoline Organophosphate
Jatrorrhizine		Natural Alkaloid Not A\/B H target Isoquinoline
Mivacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not A\/B H target
Tryptophan-tetrahydroisoquinoline-Cpd7g	BCHE	Quinoline Derivative of Tryptophan Isoquinoline
Quilostigmine	ACHE	Derivative of physostigmine-eserine Carbamate Isoquinoline Indole
Doxacurium	BCHE	Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not A\/B H target
Cisatracurium	BCHE	Propionate Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not A\/B H target