Pyrazolopyridine-Cpd37
hMGLL IC50 0.005 to 0.0005 microM
General
Chemical_Nomenclature : 5-[2-chloro-3-[3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-5-fluorophenyl]-1H-pyridin-2-one
Canonical SMILES : CC1C2=NN(C(=C2CCN1C(=O)C3=CC(=CC(=C3Cl)C4=CNC(=O)C=C4)F)C5=CC(=CC(=C5)F)F)C
InChI : InChI=1S\/C26H20ClF3N4O2\/c1-13-24-19(25(33(2)32-24)15-7-16(28)9-17(29)8-15)5-6-34(13)26(36)21-11-18(30)10-20(23(21)27)14-3-4-22(35)31-12-14\/h3-4,7-13H,5-6H2,1-2H3,(H,31,35)\/t13-\/m0\/s1 || InChI=1S\/C26H20ClF3N4O2\/c1-13-24-19(25(33(2)32-24)15-7-16(28)9-17(29)8-15)5-6-34(13)26(36)21-11-18(30)10-20(23(21)27)14-3-4-22(35)31-12-14\/h3-4,7-13H,5-6H2,1-2H3,(H,31,35)\/t13-\/m1\/s1
InChIKey : BVYLJBZGLXBQBT-ZDUSSCGKSA-N || BVYLJBZGLXBQBT-CYBMUJFWSA-N
Other name(s) : 5-[2-chloro-3-[(7R)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-5-fluorophenyl]-1H-pyridin-2-one, Compound 37, Compound 38
MW : 512.9
Formula : C26H20ClF3N4O2
CAS_number :
PubChem : 168934924, 168934676
UniChem : BVYLJBZGLXBQBT-ZDUSSCGKSA-N || BVYLJBZGLXBQBT-CYBMUJFWSA-N
Target
Families : Pyrazolopyridine-Cpd37 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Novel Pyrazolopyridine Inhibitors of Monoacylglycerol Lipase for the Treatment of Neurodegenerative Diseases and Neuroinflammation - Rosse_2024_ACS.Med.Chem.Lett_15_19 |
| Author(s) : Rosse G |
| Ref : ACS Med Chem Lett , 15 :19 , 2024 |
| PubMedID: 38229740 |