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Pyrazolopyridine-Cpd37

hMGLL IC50 0.005 to 0.0005 microM

General

Type : Pyridine, Pyrazole

Chemical_Nomenclature : 5-[2-chloro-3-[3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-5-fluorophenyl]-1H-pyridin-2-one

Canonical SMILES : CC1C2=NN(C(=C2CCN1C(=O)C3=CC(=CC(=C3Cl)C4=CNC(=O)C=C4)F)C5=CC(=CC(=C5)F)F)C

InChI : InChI=1S\/C26H20ClF3N4O2\/c1-13-24-19(25(33(2)32-24)15-7-16(28)9-17(29)8-15)5-6-34(13)26(36)21-11-18(30)10-20(23(21)27)14-3-4-22(35)31-12-14\/h3-4,7-13H,5-6H2,1-2H3,(H,31,35)\/t13-\/m0\/s1 || InChI=1S\/C26H20ClF3N4O2\/c1-13-24-19(25(33(2)32-24)15-7-16(28)9-17(29)8-15)5-6-34(13)26(36)21-11-18(30)10-20(23(21)27)14-3-4-22(35)31-12-14\/h3-4,7-13H,5-6H2,1-2H3,(H,31,35)\/t13-\/m1\/s1

InChIKey : BVYLJBZGLXBQBT-ZDUSSCGKSA-N || BVYLJBZGLXBQBT-CYBMUJFWSA-N

Other name(s) : 5-[2-chloro-3-[(7R)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-5-fluorophenyl]-1H-pyridin-2-one  ||  Compound 37  ||  Compound 38

MW : 512.9

Formula : C26H20ClF3N4O2

CAS_number :

PubChem : 168934924,    168934676

UniChem : BVYLJBZGLXBQBT-ZDUSSCGKSA-N,    BVYLJBZGLXBQBT-CYBMUJFWSA-N

Target

Families : Pyrazolopyridine-Cpd37 ligand of proteins in family
Monoglyceridelipase_lysophospholip

Protein :
human-MGLL

References (1)

Title : Novel Pyrazolopyridine Inhibitors of Monoacylglycerol Lipase for the Treatment of Neurodegenerative Diseases and Neuroinflammation - Rosse_2024_ACS.Med.Chem.Lett_15_19
Author(s) : Rosse G
Ref : ACS Med Chem Lett , 15 :19 , 2024
Abstract :
PubMedSearch : Rosse_2024_ACS.Med.Chem.Lett_15_19
PubMedID: 38229740