Pyridyl-Pyridazine-Glycoside-cpd5
IC50 values of 0.26 microM for AChE and 0.19 microM for BuChE
General
Type : Pyridazine, Triazol, Sulfure Compound, Glycoside
Chemical_Nomenclature : (2S,3R,4S,5R)-2-(4-(((6-Phenylpyridazin-3-yl)thio)methyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Canonical SMILES : C1=CC=CC(=N1)C2=NN=C(C=C2)SCC3=C[N](N=N3)[C@H]4OCC([C@H]([C@H]4OC(=O)C)OC(=O)C)OC(=O)C
InChI : InChI=1S\/C23H24N6O7S\/c1-13(30)34-19-11-33-23(22(36-15(3)32)21(19)35-14(2)31)29-10-16(25-28-29)12-37-20-8-7-18(26-27-20)17-6-4-5-9-24-17\/h4-10,19,21-23H,11-12H2,1-3H3\/t19?,21-,22-,23+\/m1\/s1
InChIKey : UALNPLQESYAXJE-PUKPPVNSSA-N
Other name(s) :
Target
Families : Pyridyl-Pyridazine-Glycoside-cpd5 ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors Based on the Pyridyl-Pyridazine Moiety for the Potential Treatment of Alzheimer's Disease - Elsawalhy_2024_Pharmaceuticals.(Basel)_17_1407 |
| Author(s) : Elsawalhy M , Abdel-Rahman AA , Basiony EA , Ellithy SA , Hassan AA , Abou-Amra ES , Ismail A , Almehizia AA , Al-Omar MA , Naglah AM , Hassan NA |
| Ref : Pharmaceuticals (Basel) , 17 : , 2024 |
| Abstract : |
| PubMedSearch : Elsawalhy_2024_Pharmaceuticals.(Basel)_17_1407 |
| PubMedID: 39459045 |