S11-1014-hydroxamide-cpd17
BChE and histone deacetylase 6 (HDAC6) dual inhibitor: eqBChE (IC50, nM) 0.3 +/- 0.1; hBChE (IC50, nM) 0.3 +/- 0.1; HDAC6 (1 microM)% 91.1; HDAC6 (100 nM)% 63.2; HDAC6 (IC50, nM) 56.7 +/- 11.9
General
Type : Multitarget, HDAC inhibitor, Isophthalamide
Chemical_Nomenclature : (E)-N1-(2-((diethylamino)methyl)benzyl)-N3-(3-(hydroxyamino)-3-oxo-prop-1-en-1-yl)phenyl)isophthalamide
Canonical SMILES : ONC(C=CC1=CC(=CC=C1)NC(C2=CC=CC(=C2)C(NCC3=CC=CC=C3CN(CC)CC)=O)=O)=O
InChI : InChI=1S\/C29H32N4O4\/c1-3-33(4-2)20-25-11-6-5-10-24(25)19-30-28(35)22-12-8-13-23(18-22)29(36)31-26-14-7-9-21(17-26)15-16-27(34)32-37\/h5-18,37H,3-4,19-20H2,1-2H3,(H,30,35)(H,31,36)(H,32,34)
InChIKey : LVAKOKQHQPGATC-UHFFFAOYSA-N
Other name(s) : Compound 17
Target
Families : S11-1014-hydroxamide-cpd17 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Dual inhibitors of butyrylcholinesterase and histone deacetylase 6 for the treatment of Alzheimers disease: design, synthesis, and biological evaluation - Lv_2025_Bioorg.Med.Chem__118219 |
| Author(s) : Lv B , Wang Z , Wang Q , Xu Z , Tang J , Pei Y , Bian Y , Sun H , Chen Y |
| Ref : Bioorganic & Medicinal Chemistry , :118219 , 2025 |
| Abstract : |
| PubMedSearch : Lv_2025_Bioorg.Med.Chem__118219 |
| PubMedID: |