SB03178
Can be chelated to diagnostic radionuclide gallium-68 or therapeutic radionuclide lutetium-177
General
Type : Pyrrolidine, Cyanide, PET probe, Tetrazacyclododec, Piperazine
Chemical_Nomenclature : 2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]benzo[h]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
Canonical SMILES : C1CN(CCN1CCCOC2=CC3=C(C=CN=C3C4=CC=CC=C42)C(=O)NCC(=O)N5CC(C[C@H]5C#N)(F)F)C(=O)CN6CCN(CCN(CCN(CC6)CC(=O)O)CC(=O)O)CC(=O)O
InChI : InChI=1S\/C44H56F2N10O10\/c45-44(46)23-31(24-47)56(30-44)37(57)25-49-43(65)34-6-7-48-42-33-5-2-1-4-32(33)36(22-35(34)42)66-21-3-8-50-17-19-55(20-18-50)38(58)26-51-9-11-52(27-39(59)60)13-15-54(29-41(63)64)16-14-53(12-10-51)28-40(61)62\/h1-2,4-7,22,31H,3,8-21,23,25-30H2,(H,49,65)(H,59,60)(H,61,62)(H,63,64)\/t31-\/m0\/s1
InChIKey : UDCRRMJKZKUNDG-HKBQPEDESA-N
Other name(s) : SCHEMBL25900378 || EX-A9735 || HY-161262 || CS-0998874
MW : 923.0
Formula : C44H56F2N10O10
CAS_number : 2952588-12-2
PubChem : 168983885
UniChem : UDCRRMJKZKUNDG-HKBQPEDESA-N
Target
Families : SB03178 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-FAP
References (3)
| Title : Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-alpha-targeted radiotheranostic for cancer imaging and therapy - Bendre_2024_Eur.J.Med.Chem_268_116238 |
| Author(s) : Bendre S , Merkens H , Kuo HT , Ng P , Wong A , Lau WS , Zhang Z , Kurkowska S , Chen CC , Uribe C , Benard F , Lin KS |
| Ref : Eur Journal of Medicinal Chemistry , 268 :116238 , 2024 |
| Abstract : |
| PubMedSearch : Bendre_2024_Eur.J.Med.Chem_268_116238 |
| PubMedID: 38367492 |
| Gene_locus related to this paper: human-FAP |
| Title : Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-alpha-targeted radiotheranostic for cancer imaging and therapy - Bendre_2024_Eur.J.Med.Chem_268_116238 |
| Author(s) : Bendre S , Merkens H , Kuo HT , Ng P , Wong A , Lau WS , Zhang Z , Kurkowska S , Chen CC , Uribe C , Benard F , Lin KS |
| Ref : Eur Journal of Medicinal Chemistry , 268 :116238 , 2024 |
| Abstract : |
| PubMedSearch : Bendre_2024_Eur.J.Med.Chem_268_116238 |
| PubMedID: 38367492 |
| Gene_locus related to this paper: human-FAP |
| Title : Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-alpha-targeted radiotheranostic for cancer imaging and therapy - Bendre_2024_Eur.J.Med.Chem_268_116238 |
| Author(s) : Bendre S , Merkens H , Kuo HT , Ng P , Wong A , Lau WS , Zhang Z , Kurkowska S , Chen CC , Uribe C , Benard F , Lin KS |
| Ref : Eur Journal of Medicinal Chemistry , 268 :116238 , 2024 |
| Abstract : |
| PubMedSearch : Bendre_2024_Eur.J.Med.Chem_268_116238 |
| PubMedID: 38367492 |
| Gene_locus related to this paper: human-FAP |