SCHEMBL21862936
IC50 DPP4 4.3 nM; DPP8 9 >1000 nM. More potent than Neogliptin
General
Type : Gliptin, Trifluoro, Azabicyclo, Oxadiazol
Chemical_Nomenclature : (3R)-3-amino-1-[(3S)-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-2-azabicyclo[2.2.1]heptan-2-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Canonical SMILES : C1CC2CC1[C@H](N2C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C4=NC(=NO4)C5=CC=CC=C5
InChI : InChI=1S\/C24H23F3N4O2\/c25-18-12-20(27)19(26)10-15(18)8-16(28)11-21(32)31-17-7-6-14(9-17)22(31)24-29-23(30-33-24)13-4-2-1-3-5-13\/h1-5,10,12,14,16-17,22H,6-9,11,28H2\/t14?,16-,17?,22+\/m1\/s1
InChIKey : YDEZZPRXJREHOZ-PMDFSGFKSA-N
Other name(s) : Compound 9a
MW : 456.5
Formula : C24H23F3N4O2
CAS_number :
PubChem : 146491234
UniChem : YDEZZPRXJREHOZ-PMDFSGFKSA-N
Target
Families : SCHEMBL21862936 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP4
References (1)
| Title : 3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM - Zinevich_2025_Pharmaceuticals.(Basel)_18_642 |
| Author(s) : Zinevich TV , Maslov IO , Kirichenko OG , Shorshnev SV , Gureev MA , Dolgushin FM , Porozov YB , Trukhan VM |
| Ref : Pharmaceuticals (Basel) , 18 : , 2025 |
| Abstract : |
| PubMedSearch : Zinevich_2025_Pharmaceuticals.(Basel)_18_642 |
| PubMedID: 40430463 |