SMR000042088
1-isobutyl-3-oxo-3,5,6,7- tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitril || SMR000042088 is reported as a brain-penetrating inhibitor of prolyl endopeptidase-like (PREPL) enzyme activity. It is a useful pharmacological tool for investigating the biochemistry and physiological function of PREPL.
General
Chemical_Nomenclature : 1-(2-methylpropyl)-3-oxo-2,5,6,7-tetrahydrocyclopenta[c]pyridine-4-carbonitrile
Canonical SMILES : CC(C)CC1=C2CCCC2=C(C(=O)N1)C#N
InChI : InChI=1S\/C13H16N2O\/c1-8(2)6-12-10-5-3-4-9(10)11(7-14)13(16)15-12\/h8H,3-6H2,1-2H3,(H,15,16)
InChIKey : QOUMCRXJXXVERM-UHFFFAOYSA-N
Other name(s) : compound 8 [PMID: 21692504] || MLS000077901 || STK649251 || SR-01000002103 || AC1LD5G0 || Oprea1_077264
MW : 216.27
Formula : C13H16N2O
CAS_number :
PubChem : 661524
UniChem : QOUMCRXJXXVERM-UHFFFAOYSA-N
IUPHAR : 8491
Target
Families : SMR000042088 ligand of proteins in family
S9N_PREPL_Peptidase_S9
Protein :
human-PREPL
References (3)
| Title : Missense variants in CMS22 patients reveal that PREPL has both enzymatic and non-enzymatic functions - Monnens_2024_JCI.Insight__e179276 |
| Author(s) : Monnens Y , Theodoropoulou A , Rosier K , Bhalla K , Mahy A , Vanhoutte R , Meulemans S , Cavani E , Antanasijevic A , Lemmens I , Lee JA , Spellicy CJ , Schroer RJ , Maselli RA , Laverty CG , Agostinis P , Pagliarini DJ , Verhelst S , Marcaida MJ , Rochtus A , Dal Peraro M , Creemers JW |
| Ref : JCI Insight , : , 2024 |
| Abstract : |
| PubMedSearch : Monnens_2024_JCI.Insight__e179276 |
| PubMedID: 39078710 |
| Gene_locus related to this paper: human-PREPL |
| Title : Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function - Rosier_2021_iScience_24_103460 |
| Author(s) : Rosier K , McDevitt MT , Smet J , Floyd BJ , Verschoore M , Marcaida MJ , Bingman CA , Lemmens I , Dal Peraro M , Tavernier J , Cravatt BF , Gounko NV , Vints K , Monnens Y , Bhalla K , Aerts L , Rashan EH , Vanlander AV , Van Coster R , Regal L , Pagliarini DJ , Creemers JWM |
| Ref : iScience , 24 :103460 , 2021 |
| Abstract : |
| PubMedSearch : Rosier_2021_iScience_24_103460 |
| PubMedID: 34888501 |
| Gene_locus related to this paper: human-PREPL |
| Title : A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors - Lone_2011_J.Am.Chem.Soc_133_11665 |
| Author(s) : Lone AM , Bachovchin DA , Westwood DB , Speers AE , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF , Saghatelian A |
| Ref : Journal of the American Chemical Society , 133 :11665 , 2011 |
| Abstract : |
| PubMedSearch : Lone_2011_J.Am.Chem.Soc_133_11665 |
| PubMedID: 21692504 |
| Gene_locus related to this paper: human-PREPL |