SPFTD-4
IC50 66.03 nM
General
Type : Derivative of Tacrine, Acridine, Carboxamide
Chemical_Nomenclature : 9-amino-6-(3,5-difluorophenyl)-N-(prop-2-yn-1-yl)-1,2,3,4-tetrahydroacridine-2-carboxamide
Canonical SMILES : C1(=CC(=CC(=C1)C2=CC3=C(C=C2)C(=C4C(=N3)CCC(C4)C(=O)NCC#C)N)F)F
InChI : InChI=1S\/C23H19F2N3O\/c1-2-7-27-23(29)14-4-6-20-19(10-14)22(26)18-5-3-13(11-21(18)28-20)15-8-16(24)12-17(25)9-15\/h1,3,5,8-9,11-12,14H,4,6-7,10H2,(H2,26,28)(H,27,29)
InChIKey : UGHYATSSCRFLJC-UHFFFAOYSA-N
Other name(s) :
Target
Families : SPFTD-4 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Sub-pocket-focused designing of tacrine derivatives as potential acetylcholinesterase inhibitors - Babu_2023_Comput.Biol.Med_155_106666 |
| Author(s) : Babu A , John M , Liji MJ , Maria E , Bhaskar SJ , Binukmar BK , Sajith AM , Reddy EK , Dileep KV , Sunil K |
| Ref : Computers in Biology & Medicine , 155 :106666 , 2023 |
| Abstract : |
| PubMedSearch : Babu_2023_Comput.Biol.Med_155_106666 |
| PubMedID: 36841058 |