Sanguinine
Sanguinine is a natural product found in Lycoris sanguinea, Lycoris squamigera Desmethyl Galanthamine
General
Type : Derivative of Galanthamine, Natural, Alkaloid
Chemical_Nomenclature : (1S,12S,14R)-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraene-9,14-diol
Canonical SMILES : CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)O)O
InChI : InChI=1S\/C16H19NO3\/c1-17-7-6-16-5-4-11(18)8-13(16)20-15-12(19)3-2-10(9-17)14(15)16\/h2-5,11,13,18-19H,6-9H2,1H3\/t11-,13-,16-\/m0\/s1
InChIKey : OYSGWKOGUVOGFQ-RBOXIYTFSA-N
Other name(s) : O-Desmethyl Galanthamine || O-Desmethylgalantamine || O-demethyl galantamine
MW : 273.33
Formula : C16H19NO3
CAS_number : 60755-80-8
PubChem : 443722
UniChem : OYSGWKOGUVOGFQ-RBOXIYTFSA-N
Target
Families : Sanguinine ligand of proteins in family
ACHE
Protein :
human-ACHE
References (9)
| Title : O-demethyl galantamine alters protein expression in cerebellum of 5xFAD mice - Kiris_2024_Turk.J.Biol_48_163 |
| Author(s) : Kiris I , Karayel Basar M , Gurel B , Mroczek T , Baykal AT |
| Ref : Turk J Biol , 48 :163 , 2024 |
| Abstract : |
| PubMedSearch : Kiris_2024_Turk.J.Biol_48_163 |
| PubMedID: 39050707 |
| Title : Chemical Survey of Three Species of the Genus Rauhia Traub (Amaryllidaceae) - Tallini_2022_Plants.(Basel)_11_ |
| Author(s) : Tallini LR , Osorio EH , Berkov S , Torras-Claveria L , Rodriguez-Escobar ML , Viladomat F , Meerow AW , Bastida J |
| Ref : Plants (Basel) , 11 : , 2022 |
| Abstract : |
| PubMedSearch : Tallini_2022_Plants.(Basel)_11_ |
| PubMedID: 36559661 |
| Title : Gigantelline, gigantellinine and gigancrinine, cherylline- and crinine-type alkaloids isolated from Crinum jagus with anti-acetylcholinesterase activity - Ka_2020_Phytochemistry_175_112390 |
| Author(s) : Ka S , Masi M , Merindol N , Di Lecce R , Plourde MB , Seck M , Gorecki M , Pescitelli G , Desgagne-Penix I , Evidente A |
| Ref : Phytochemistry , 175 :112390 , 2020 |
| Abstract : |
| PubMedSearch : Ka_2020_Phytochemistry_175_112390 |
| PubMedID: 32335411 |
| Title : Cholinesterase-inhibitory effect and in silico analysis of alkaloids from bulbs of Hieronymiella species - Ortiz_2018_Phytomedicine_39_66 |
| Author(s) : Ortiz JE , Garro A , Pigni NB , Aguero MB , Roitman G , Slanis A , Enriz RD , Feresin GE , Bastida J , Tapia A |
| Ref : Phytomedicine , 39 :66 , 2018 |
| Abstract : |
| PubMedSearch : Ortiz_2018_Phytomedicine_39_66 |
| PubMedID: 29433685 |
| Title : Cooperative hydrogen bonds and mobility of the non-aromatic ring as selectivity determinants for human acetylcholinesterase to similar anti-Alzheimer's galantaminics: a computational study - Rocha_2018_J.Biomol.Struct.Dyn__1 |
| Author(s) : Rocha REO , Lima LHF |
| Ref : J Biomol Struct Dyn , :1 , 2018 |
| Abstract : |
| PubMedSearch : Rocha_2018_J.Biomol.Struct.Dyn__1 |
| PubMedID: 29697300 |
| Title : Alkaloids from Habranthus tubispathus and H. jamesonii, two amaryllidaceae with acetyl- and butyrylcholinesterase inhibition activity - Cavallaro_2014_Nat.Prod.Commun_9_159 |
| Author(s) : Cavallaro V , Alza NP , Murray MG , Murray AP |
| Ref : Nat Prod Commun , 9 :159 , 2014 |
| Abstract : |
| PubMedSearch : Cavallaro_2014_Nat.Prod.Commun_9_159 |
| PubMedID: 24689279 |
| Title : GC-MS of amaryllidaceous galanthamine-type alkaloids - Berkov_2012_J.Mass.Spectrom_47_1065 |
| Author(s) : Berkov S , Viladomat F , Codina C , Suarez S , Ravelo A , Bastida J |
| Ref : J Mass Spectrom , 47 :1065 , 2012 |
| Abstract : |
| PubMedSearch : Berkov_2012_J.Mass.Spectrom_47_1065 |
| PubMedID: 22899516 |
| Title : Rapid TLC\/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts - Berkov_2008_Phytochem.Anal_19_411 |
| Author(s) : Berkov S , Bastida J , Nikolova M , Viladomat F , Codina C |
| Ref : Phytochem Anal , 19 :411 , 2008 |
| Abstract : |
| PubMedSearch : Berkov_2008_Phytochem.Anal_19_411 |
| PubMedID: 18446766 |
| Title : Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts - Lopez_2002_Life.Sci_71_2521 |
| Author(s) : Lopez S , Bastida J , Viladomat F , Codina C |
| Ref : Life Sciences , 71 :2521 , 2002 |
| Abstract : |
| PubMedSearch : Lopez_2002_Life.Sci_71_2521 |
| PubMedID: 12270757 |