Sulphostin-cpd16
General
Type : Sulfur Compound, Organophosphate, Piperidine
Chemical_Nomenclature : (3S)-3-amino-1-[(R\/S)-ethoxy(2-(4-pentylphenylthio) ethyl)phosphoryl] piperidin-2-one trifluoroacetate
Canonical SMILES : C1CN(C([C@@H](C1)N)=O)[P](=O)(CCSC2=CC=C(C=C2)CCCCC)OCC
InChI : InChI=1S\/C20H33N2O3PS\/c1-3-5-6-8-17-10-12-18(13-11-17)27-16-15-26(24,25-4-2)22-14-7-9-19(21)20(22)23\/h10-13,19H,3-9,14-16,21H2,1-2H3\/t19-,26?\/m1\/s1
InChIKey : QEROMPKKSHUCMR-ICCFGIFFSA-N
Other name(s) :
Target
Families : Sulphostin-cpd16 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP9
References (1)
| Title : Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors - Sewald_2025_Nat.Commun_16_3208 |
| Author(s) : Sewald L , Tabak WWA , Fehr L , Zolg S , Najdzion M , Verhoef CJA , Podlesainski D , Geiss-Friedlander R , Lammens A , Kaschani F , Hellerschmied D , Huber R , Kaiser M |
| Ref : Nat Commun , 16 :3208 , 2025 |
| Abstract : |
| PubMedSearch : Sewald_2025_Nat.Commun_16_3208 |
| PubMedID: 40180908 |
| Gene_locus related to this paper: human-DPP4 , human-DPP8 , human-DPP9 |