Tiratricol
Thyroid hormone anlogue. binds Thyroid hormone receptor, but also CFTR inhibitory factor Cif. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations.
General
Type : Natural, Drug, Thyroid hormone analogue
Chemical_Nomenclature : 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
Canonical SMILES : C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O
InChI : InChI=1S\/C14H9I3O4\/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20\/h1-4,6,18H,5H2,(H,19,20)
InChIKey : UOWZUVNAGUAEQC-UHFFFAOYSA-N
Other name(s) : Triac || 3,3',5-triodothyroacetic acid || UNII-29OQ9EU4R1 || CHEMBL41632 || 4HY
MW : 621.93
Formula : C14H9I3O4
CAS_number : 51-24-1
PubChem : 5803
UniChem : UOWZUVNAGUAEQC-UHFFFAOYSA-N
IUPHAR : 2637
Target
Families : Tiratricol ligand of proteins in family
CFTR-inhibitory-factor_Cif
Structure :
4YX9
Protein :
pseae-PA2934
References (2)
| Title : Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa - Kitamura_2016_J.Med.Chem_59_4790 |
| Author(s) : Kitamura S , Hvorecny KL , Niu J , Hammock BD , Madden DR , Morisseau C |
| Ref : Journal of Medicinal Chemistry , 59 :4790 , 2016 |
| Abstract : |
| PubMedSearch : Kitamura_2016_J.Med.Chem_59_4790 |
| PubMedID: 27120257 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR - Bahl_2015_Angew.Chem.Int.Ed.Engl_54_9881 |
| Author(s) : Bahl CD , Hvorecny KL , Bomberger JM , Stanton BA , Hammock BD , Morisseau C , Madden DR |
| Ref : Angew Chem Int Ed Engl , 54 :9881 , 2015 |
| Abstract : |
| PubMedSearch : Bahl_2015_Angew.Chem.Int.Ed.Engl_54_9881 |
| PubMedID: 26136396 |
| Gene_locus related to this paper: pseae-PA2934 |