pseae-PA2934
Pseudomonas aeruginosa (strains PA01, PA2934 LESB58; 2192; UCBPP-PA14; C3719) the CFTR inhibitory factor Cif an epoxide hydrolase virulence factor
Comment
Relationship
Family : CFTR-inhibitory-factor_Cif
Block : X
Position in NCBI Life Tree : Pseudomonas aeruginosa
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Pseudomonadales N E > Pseudomonadaceae N E > Pseudomonas N E > Pseudomonas aeruginosa group N E > Pseudomonas aeruginosa N EMolecular evidence
No mutation
3KD2 - Crystal structure of the CFTR inhibitory factor Cif an epoxide hydrolase virulence factor
3KDA - Crystal structure of the CFTR inhibitory factor Cif an epoxide hydrolase virulence factor with the H269A mutation
3PI6 - Crystal structure of the CFTR inhibitory factor Cif with the H177Y mutation
4DLN - Crystal structure of the CFTR inhibitory factor Cif with the D129S mutation
4DM7 - Crystal structure of the CFTR inhibitory factor Cif with the E153D mutation
4DMC - Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation
4DMF - Crystal structure of the CFTR inhibitory factor Cif with the H177A mutation
4DMH - Crystal structure of the CFTR inhibitory factor Cif with the H2071 mutation
4DMK - Crystal structure of the CFTR inhibitory factor Cif with the Y239F mutation
4DNF - Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation adducted with the epibromohydrin hydrolysis intermediate
4DNO - Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation adducted with the 1,2-epoxyhexane hydrolysis intermediate
4EHB - Crystal structure of the CFTR inhibitory factor Cif with the D129S mutation bound to epoxyhexane
4EUS - Crystal structure of the CFTR inhibitory factor Cif bound to 1,2-hexanediol
4YX9 - Crystal structure of the CFTR inhibitory factor Cif bound to tiratricol
5HK9 - Crystal structure of the CFTR inhibitory factor Cif bound to an urea inhibitor
5HKA - Crystal structure of the CFTR inhibitory factor Cif bound to an amide inhibitor
5HKB - Crystal structure of the CFTR inhibitory factor Cif bound to the inhibitor KB2115 Eprotirome
5JYC - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate
5TND - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 7-oxa-bicyclo[4.1.0]heptan (epoxycyclohexane) ECH
5TNE - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (2R,3S)-2,3-diphenyloxirane (cis-stilbene oxide) cSO
5TNF - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 19,20-EDP (epoxy-docosapentaenoic acid)
5TNG - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EPETE (epoxy-eicosatetraenoic acid)
5TNH - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 17,18-EpETE (epoxy-eicosatetraenoic acid) hydrolysis intermediate
5TNI - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted S-Styrene oxide (S-2-phenyloxirane) hydrolysis intermediate S-SOx
5TNJ - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 4-Vinyl-1-cyclohexene 1,2-epoxide hydrolysis intermediate (VCH)
5TNK - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted rac-1,2-epoxyoctane (2-hexyloxirane) hydrolysis intermediate (rac-EpO)
5TNL - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted S-2-butyloxirane (S-1,2-epoxyhexane) hydrolysis intermediate (S-EpH)
5TNM - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted R-1,2-epoxyoctane (R-2-hexyloxirane) hydrolysis intermediate (R-EpO)
5TNN - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted S-1,2-epoxyoctane (S-2-hexyloxirane) hydrolysis intermediate (S-EpO)
5TNP - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted rac-Styrene oxide (rac-2-phenyloxirane) hydrolysis intermediate (rac-SOx)
5TNQ - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted R-Styrene oxide (R-2-phenyloxirane) hydrolysis intermediate (R-SOx)
5TNR - Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 16,17-EDP (epoxy-docosapentaenoic acid) hydrolysis intermediate
5TNS - Crystal structure of the D129S mutant of the CFTR inhibitory factor Cif containing the adducted 7-oxa-bicyclo[4.1.0]heptane (epoxycyclohexane) (ECH) hydrolysis intermediate
8EVD - Crystal Structure of Nanobody VHH101 Bound to Its Antigen PA14 Cif
8F6U - Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif
8F6V - Crystal Structure of Nanobody VHH108 Bound to Its Antigen PA14 Cif
No kinetic
No disease
Sequence
Peptide
MILDRLCRGL LAGIALTFSL GGFAAEEFPV PNGFESAYRE VDGVKLHYVK GGQGPLVMLV HGFGQTWYEW HQLMPELAKR FTVIAPDLPG LGQSEPPKTG YSGEQVAVYL HKLARQFSPD RPFDLVAHDI GIWNTYPMVV KNQADIARLV YMEAPIPDAR IYRFPAFTAQ GESLVWHFSF FAADDRLAET LIAGKERFFL EHFIKSHSSN TEVFSERLLD LYARSYAKPH SLNASFEYYR ALNESVRQNA ELAKTRLQMP TMTLAGGGHG GMGTFQLEQM KAYADDVEGH VLPGCGHWLP EECAAPMNRL VIDFLSRGR
References (21)
| Title : Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa - He_2024_Nucleic.Acids.Res__ |
| Author(s) : He S , Taher NM , Simard AR , Hvorecny KL , Ragusa MJ , Bahl CD , Hickman AB , Dyda F , Madden DR |
| Ref : Nucleic Acids Research , : , 2024 |
| Abstract : |
| PubMedSearch : He_2024_Nucleic.Acids.Res__ |
| PubMedID: 39413156 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa - He_2024_bioRxiv__ |
| Author(s) : He S , Taher NM , Hvorecny KL , Ragusa MJ , Bahl CD , Hickman AB , Dyda F , Madden DR |
| Ref : Biorxiv , : , 2024 |
| Abstract : |
| PubMedSearch : He_2024_bioRxiv__ |
| PubMedID: 38293063 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase - Hvorecny_2017_Structure_25_697 |
| Author(s) : Hvorecny KL , Bahl CD , Kitamura S , Lee KSS , Hammock BD , Morisseau C , Madden DR |
| Ref : Structure , 25 :697 , 2017 |
| Abstract : |
| PubMedSearch : Hvorecny_2017_Structure_25_697 |
| PubMedID: 28392259 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators - Flitter_2017_Proc.Natl.Acad.Sci.U.S.A_114_136 |
| Author(s) : Flitter BA , Hvorecny KL , Ono E , Eddens T , Yang J , Kwak DH , Bahl CD , Hampton TH , Morisseau C , Hammock BD , Liu X , Lee JS , Kolls JK , Levy BD , Madden DR , Bomberger JM |
| Ref : Proc Natl Acad Sci U S A , 114 :136 , 2017 |
| Abstract : |
| PubMedSearch : Flitter_2017_Proc.Natl.Acad.Sci.U.S.A_114_136 |
| PubMedID: 27980032 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa - Kitamura_2016_J.Med.Chem_59_4790 |
| Author(s) : Kitamura S , Hvorecny KL , Niu J , Hammock BD , Madden DR , Morisseau C |
| Ref : Journal of Medicinal Chemistry , 59 :4790 , 2016 |
| Abstract : |
| PubMedSearch : Kitamura_2016_J.Med.Chem_59_4790 |
| PubMedID: 27120257 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif - Bahl_2016_Biochemistry_55_788 |
| Author(s) : Bahl CD , Hvorecny KL , Morisseau C , Gerber SA , Madden DR |
| Ref : Biochemistry , 55 :788 , 2016 |
| Abstract : |
| PubMedSearch : Bahl_2016_Biochemistry_55_788 |
| PubMedID: 26752215 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR - Bahl_2015_Angew.Chem.Int.Ed.Engl_54_9881 |
| Author(s) : Bahl CD , Hvorecny KL , Bomberger JM , Stanton BA , Hammock BD , Morisseau C , Madden DR |
| Ref : Angew Chem Int Ed Engl , 54 :9881 , 2015 |
| Abstract : |
| PubMedSearch : Bahl_2015_Angew.Chem.Int.Ed.Engl_54_9881 |
| PubMedID: 26136396 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Pseudomonas aeruginosa Cif Protein Enhances the Ubiquitination and Proteasomal Degradation of the Transporter Associated with Antigen Processing (TAP) and Reduces Major Histocompatibility Complex (MHC) Class I Antigen Presentation - Bomberger_2014_J.Biol.Chem_289_152 |
| Author(s) : Bomberger JM , Ely KH , Bangia N , Ye S , Green KA , Green WR , Enelow RI , Stanton BA |
| Ref : Journal of Biological Chemistry , 289 :152 , 2014 |
| Abstract : |
| PubMedSearch : Bomberger_2014_J.Biol.Chem_289_152 |
| PubMedID: 24247241 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Signature motifs identify an acinetobacter cif virulence factor with epoxide hydrolase activity - Bahl_2014_J.Biol.Chem_289_7460 |
| Author(s) : Bahl CD , Hvorecny KL , Bridges AA , Ballok AE , Bomberger JM , Cady KC , O'Toole GA , Madden DR |
| Ref : Journal of Biological Chemistry , 289 :7460 , 2014 |
| Abstract : |
| PubMedSearch : Bahl_2014_J.Biol.Chem_289_7460 |
| PubMedID: 24474692 |
| Gene_locus related to this paper: pseae-PA2934 , 9gamm-d0bwk6 |
| Title : Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa - Ballok_2012_J.Bacteriol_194_5315 |
| Author(s) : Ballok AE , Bahl CD , Dolben EL , Lindsay AK , St Laurent JD , Hogan DA , Madden DR , O'Toole GA |
| Ref : Journal of Bacteriology , 194 :5315 , 2012 |
| Abstract : |
| PubMedSearch : Ballok_2012_J.Bacteriol_194_5315 |
| PubMedID: 22843844 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Pseudomonas aeruginosa Cif defines a distinct class of alpha\/beta epoxide hydrolases utilizing a His\/Tyr ring-opening pair - Bahl_2012_Protein.Pept.Lett_19_186 |
| Author(s) : Bahl CD , Madden DR |
| Ref : Protein Pept Lett , 19 :186 , 2012 |
| Abstract : |
| PubMedSearch : Bahl_2012_Protein.Pept.Lett_19_186 |
| PubMedID: 21933119 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system - Bomberger_2011_PLoS.Pathog_7_e1001325 |
| Author(s) : Bomberger JM , Ye S , Maceachran DP , Koeppen K , Barnaby RL , O'Toole GA , Stanton BA |
| Ref : PLoS Pathog , 7 :e1001325 , 2011 |
| Abstract : |
| PubMedSearch : Bomberger_2011_PLoS.Pathog_7_e1001325 |
| PubMedID: 21455491 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa - Bahl_2010_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_66_26 |
| Author(s) : Bahl CD , Maceachran DP , O'Toole GA , Madden DR |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 66 :26 , 2010 |
| Abstract : |
| PubMedSearch : Bahl_2010_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_66_26 |
| PubMedID: 20057063 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Crystal structure of the CFTR inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. - Bahl_2010_J.Bacteriol_192_1785 |
| Author(s) : Bahl CD , Morisseau C , Bomberger JM , Stanton BA , Hammock BD , O'Toole GA , Madden DR |
| Ref : Journal of Bacteriology , 192 :1785 , 2010 |
| Abstract : |
| PubMedSearch : Bahl_2010_J.Bacteriol_192_1785 |
| PubMedID: 20118260 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif - Ye_2008_Am.J.Physiol.Cell.Physiol_295_C807 |
| Author(s) : Ye S , Maceachran DP , Hamilton JW , O'Toole GA , Stanton BA |
| Ref : American Journal of Physiology Cell Physiol , 295 :C807 , 2008 |
| Abstract : |
| PubMedSearch : Ye_2008_Am.J.Physiol.Cell.Physiol_295_C807 |
| PubMedID: 18650266 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : Cif is negatively regulated by the TetR family repressor CifR - MacEachran_2008_Infect.Immun_76_3197 |
| Author(s) : Maceachran DP , Stanton BA , O'Toole GA |
| Ref : Infect Immun , 76 :3197 , 2008 |
| Abstract : |
| PubMedSearch : MacEachran_2008_Infect.Immun_76_3197 |
| PubMedID: 18458065 |
| Gene_locus related to this paper: pseae-PA2934 |
| Title : The Pseudomonas aeruginosa secreted protein PA2934 decreases apical membrane expression of the cystic fibrosis transmembrane conductance regulator - MacEachran_2007_Infect.Immun_75_3902 |
| Author(s) : Maceachran DP , Ye S , Bomberger JM , Hogan DA , Swiatecka-Urban A , Stanton BA , O'Toole GA |
| Ref : Infect Immun , 75 :3902 , 2007 |
| Abstract : |
| PubMedSearch : MacEachran_2007_Infect.Immun_75_3902 |
| PubMedID: 17502391 |
| Gene_locus related to this paper: pseae-PA2934 |