Tricyclic-cyclohepta-thiophene-cpd9
AChE IC50 0.51 microM; BChE IC50 2.48 microM
General
Type : Sulfure compound, Oxazine
Chemical_Nomenclature : 2,3-Diphenyl-2,3,6,7,8,9-hexahydro-4H,5H-cyclohepta[4,5]thieno[3,2-e][1,3]oxazin-4-one
Canonical SMILES : C14=C(OC(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)SC5=C4CCCCC5
InChI : InChI=1S\/C23H21NO2S\/c25-21-20-18-14-8-3-9-15-19(18)27-23(20)26-22(16-10-4-1-5-11-16)24(21)17-12-6-2-7-13-17\/h1-2,4-7,10-13,22H,3,8-9,14-15H2
InChIKey : MRZODELYPSRORZ-UHFFFAOYSA-N
Other name(s) : Compound 9
Target
Families : Tricyclic-cyclohepta-thiophene-cpd9 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of novel bicyclic and tricyclic cyclohepta[b]thiophene derivatives as multipotent AChE and BChE inhibitors, in-Vivo and in-Vitro assays, ADMET and molecular docking simulation - Fayed_2024_Eur.J.Med.Chem_284_117201 |
| Author(s) : Fayed EA , El-Sebaey SA , Ebrahim MA , Abu-Elfotuh K , El-Sayed Mansour R , Mohamed EK , Hamdan AME , Al-Subaie FT , Albalawi GS , Albalawi TM , Hamdan AM , Mohammed AA , Ramsis TM |
| Ref : Eur Journal of Medicinal Chemistry , 284 :117201 , 2024 |
| Abstract : |
| PubMedSearch : Fayed_2024_Eur.J.Med.Chem_284_117201 |
| PubMedID: 39731791 |