Tryptophan-tetrahydroisoquinoline-Cpd7g
IC50 > 10 microM for AChE and IC50 = 0.3 microM for BuChE
General
Type : Quinoline, Derivative of Tryptophan, Isoquinoline
Chemical_Nomenclature : (2R)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-2-(2-ethylbutylamino)-3-(1H-indol-3-yl)propanamide
Canonical SMILES : CCC(CC)CN[C@H](CC1=CNC2=CC=CC=C21)C(=O)NCCN3CCC4=CC=CC=C4C3
InChI : InChI=1S\/C28H38N4O\/c1-3-21(4-2)18-30-27(17-24-19-31-26-12-8-7-11-25(24)26)28(33)29-14-16-32-15-13-22-9-5-6-10-23(22)20-32\/h5-12,19,21,27,30-31H,3-4,13-18,20H2,1-2H3,(H,29,33)\/t27-\/m1\/s1
InChIKey : HLNQKBILRCWQJR-HHHXNRCGSA-N
Other name(s) :
MW : 446.6
Formula : C28H38N4O
CAS_number :
PubChem : 169102458
UniChem : HLNQKBILRCWQJR-HHHXNRCGSA-N
Target
Families : Tryptophan-tetrahydroisoquinoline-Cpd7g ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of Tryptophan-tetrahydroisoquinoline Derivatives as Multifunctional Agents for Treatment of Alzheimer's Disease - Lu_2022_Chin.J.Chem_40_1821 |
| Author(s) : Lu X , Liu Y , Qin N , Du C , Hu Y , Chen Y , Sun H |
| Ref : Chin J Chem , 40 :1821 , 2022 |
| Abstract : |
| PubMedSearch : Lu_2022_Chin.J.Chem_40_1821 |
| PubMedID: |