Ungeremine
Inhibitor of acetylcholinesterase and butyrylcholinesterase, with the IC(50) values of 0.10 and 1.21 microM
General
Type : Natural, Alkaloid, Phenanthrene, Phenanthridinium
Chemical_Nomenclature : 5,7-dioxa-12-azoniapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-1(18),2,4(8),9,11,15(19),16-heptaen-17-ol
Canonical SMILES : C1C[N+]2=CC3=CC4=C(C=C3C5=CC(=CC1=C52)O)OCO4
InChI : InChI=1S\/C16H11NO3\/c18-11-3-9-1-2-17-7-10-4-14-15(20-8-19-14)6-12(10)13(5-11)16(9)17\/h3-7H,1-2,8H2\/p+1
InChIKey : DFQOXFIPAAMFAU-UHFFFAOYSA-O
Other name(s) : 9EVC5B2RPS || Lycoranium, 1,2,3,3a,6,7,12b,12c-octadehydro-2-hydroxy- || DTXSID50175439 || 4,5-Dihydro-2-hydroxy-(1,3)dioxolo(4,5-j)pyrrolo(3,2,1-de)phenanthridinium || (1,3)Dioxolo(4,5-j)pyrrolo(3,2,1-de)phenanthridinium, 4,5-dihydro-2-hydroxy- || RefChem:933810 || Lycobetaine || CHEMBL253553 || SCHEMBL20741474 || HY-N1971 || Lycobetaine chloride
Target
Families : Ungeremine ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (4)
| Title : Amaryllidaceae alkaloids from the bulbs of Crinum latifolium L. and their cholinesterase inhibitory activities - Chaichompoo_2023_Phytochemistry__113929 |
| Author(s) : Chaichompoo W , Rojsitthisak P , Pabuprapap W , Siriwattanasathien Y , Yotmanee P , Suksamrarn A |
| Ref : Phytochemistry , :113929 , 2023 |
| Abstract : |
| PubMedSearch : Chaichompoo_2023_Phytochemistry__113929 |
| PubMedID: 37984589 |
| Title : Alkaloids with cholinesterase inhibitory activities from the bulbs of Crinum x amabile Donn ex Ker Gawl - Chaichompoo_2022_Phytochemistry_205_113473 |
| Author(s) : Chaichompoo W , Rojsitthisak P , Pabuprapap W , Siriwattanasathien Y , Yotmanee P , Suksamrarn A |
| Ref : Phytochemistry , 205 :113473 , 2022 |
| Abstract : |
| PubMedSearch : Chaichompoo_2022_Phytochemistry_205_113473 |
| PubMedID: 36244402 |
| Title : Two new alkaloids from Crinum asiaticum var. japonicum - Endo_2019_J.Nat.Med_73_648 |
| Author(s) : Endo Y , Sugiura Y , Funasaki M , Kagechika H , Ishibashi M , Ohsaki A |
| Ref : J Nat Med , 73 :648 , 2019 |
| Abstract : |
| PubMedSearch : Endo_2019_J.Nat.Med_73_648 |
| PubMedID: 30963375 |
| Title : Isolation of the acetylcholinesterase inhibitor ungeremine from Nerine bowdenii by preparative HPLC coupled on-line to a flow assay system - Rhee_2004_Biol.Pharm.Bull_27_1804 |
| Author(s) : Rhee IK , Appels N , Hofte B , Karabatak B , Erkelens C , Stark LM , Flippin LA , Verpoorte R |
| Ref : Biol Pharm Bull , 27 :1804 , 2004 |
| Abstract : |
| PubMedSearch : Rhee_2004_Biol.Pharm.Bull_27_1804 |
| PubMedID: 15516727 |