Vibralactone-derivative-Cpd1
inhibition of Pancreatic lipase, with an IC50 value of 14 nM
General
Type : Lactone, Lipase inhibitor, Carboxamide
Chemical_Nomenclature : (1R,5S)-N-heptyl-1-(3-methylbut-2-en-1-yl)-N-octyl-7-oxo-6-oxabicyclo[3.2.0]hept-2-ene-3-carboxamide || (1R)-1-(3-methylbut-2-enyl)-N,N-dioctyl-7-oxo-6-oxabicyclo[3.2.0]hept-2-ene-3-carboxamide
Canonical SMILES : CCCCCCCCN(CCCCCCCC)C(=O)C1=C[C@@]2(C(C1)OC2=O)CC=C(C)C
InChI : InChI=1S\/C28H47NO3\/c1-5-7-9-11-13-15-19-29(20-16-14-12-10-8-6-2)26(30)24-21-25-28(22-24,27(31)32-25)18-17-23(3)4\/h17,22,25H,5-16,18-21H2,1-4H3\/t25?,28-\/m1\/s1
InChIKey : HHRWFVCNZWPRKP-MPSNESSQSA-N
Other name(s) : compound C1
MW : 445.7
Formula : C28H47NO3
CAS_number :
PubChem : 163613173
UniChem : HHRWFVCNZWPRKP-MPSNESSQSA-N
Target
Families : Vibralactone-derivative-Cpd1 ligand of proteins in family
Pancreatic_lipase
Protein :
human-PNLIP
References (1)
| Title : Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents - Wei_2015_Nat.Prod.Bioprospect_5_129 |
| Author(s) : Wei K , Wang GQ , Bai X , Niu YF , Chen HP , Wen CN , Li ZH , Dong ZJ , Zuo ZL , Xiong WY , Liu JK |
| Ref : Nat Prod Bioprospect , 5 :129 , 2015 |
| Abstract : |
| PubMedSearch : Wei_2015_Nat.Prod.Bioprospect_5_129 |
| PubMedID: 26085282 |
| Gene_locus related to this paper: human-PNLIP |