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Lactone

General

Lactones are cyclic carboxylic esters, containing a 1-oxacycloalkan-2-one structure (C(=O)O). Lactones are formed by intramolecular esterification. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
5-Deoxystrigol RsbQ-like Plant hormone Strigolactone Strigolactone receptors ligand Natural Inden
GR24 RsbQ-like Fungal-D14-Strigolactone-R Plant_carboxylesterase Strigolactone Strigolactone receptors ligand Inden
3-benzyl-4-tridecyloxetan-2-one-trans5c Carb_B_Chordata abh_upf0017 ABHD12-PHARC ABHD16 Thioesterase Tridecyl Lactone Oxooxetan
CLIM RsbQ-like Natural Plant hormone Strigolactone receptors ligand
A1L2E RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
NPD14805 RsbQ-like Strigolactone receptors ligand Quinoline
KK181-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
Zaxinone RsbQ-like Natural Plant hormone Strigolactone receptors ligand
Solanacyl-acetate RsbQ-like Strigolactone receptors ligand Canonical strigolactone Plant hormone Acetate
Solanacol RsbQ-like Strigolactone receptors ligand Plant hormone Canonical strigolactone
Avenaol RsbQ-like Strigolactone receptors ligand Non-canonical strigolactone Plant hormone
Bryosymbiol RsbQ-like Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
MeCLA RsbQ-like Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
Cannalactone RsbQ-like Strigolactone Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
XM-47 RsbQ-like Naphthalen Strigolactone receptors ligand
2-methoxy-1-naphthaldehyde RsbQ-like Naphthalen Strigolactone receptors ligand
Carlactonoic-acid RsbQ-like Strigolactone receptors ligand Non-canonical strigolactone
Vibralactone Pancreatic_lipase Natural Lactone Lipase inhibitor
Vibralactone-derivative-Cpd1 Pancreatic_lipase Lactone Lipase inhibitor Carboxamide
RG6 RsbQ-like Strigolactone receptors ligand
Soporidine RsbQ-like Alkyne Piperidine Trifluoro Strigolactone receptors ligand
Germinone-A RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
dMgerminone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
4-CN-desmethyl-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand Cyanide
4-CN-Debranone RsbQ-like Strigolactone Debranone Cyanide Strigolactone receptors ligand
4-Cl-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand Organochlorine
4-Br-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
Rocaglate-Derived-beta-Lactone-5 ABHD10 Carboxypeptidase_S10 Acyl-CoA_Thioesterase Lactone Benzofuran
KK023-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK023-N2 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK094 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
7-carba-4BD-ring-opened RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
7-carba-4BD RsbQ-like Strigolactone Debranone Butenolide Strigolactone receptors ligand
Hydroxy-D-ring RsbQ-like Plant_carboxylesterase Butenolide Plant hormone Strigolactone receptors ligand Strigolactone Natural
Methyl-phenlactonoate-butenolide-3 RsbQ-like Methyl Phenlactonoate Strigolactone receptors ligand Butenolide Dihydrofuran
Methyl-phenlactonoate-butenolide-16 RsbQ-like Methyl Phenlactonoate Strigolactone receptors ligand Butenolide
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Indole Butenolide Phthalimido Dihydrofuran
5-Deoxystrigol RsbQ-like Plant hormone Strigolactone Strigolactone receptors ligand Natural Inden
GR24 RsbQ-like Fungal-D14-Strigolactone-R Plant_carboxylesterase Strigolactone Strigolactone receptors ligand Inden
3-benzyl-4-tridecyloxetan-2-one-trans5c Carb_B_Chordata abh_upf0017 ABHD12-PHARC ABHD16 Thioesterase Tridecyl Lactone Oxooxetan
CLIM RsbQ-like Natural Plant hormone Strigolactone receptors ligand
A1L2E RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
NPD14805 RsbQ-like Strigolactone receptors ligand Quinoline
KK181-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
Zaxinone RsbQ-like Natural Plant hormone Strigolactone receptors ligand
Solanacyl-acetate RsbQ-like Strigolactone receptors ligand Canonical strigolactone Plant hormone Acetate
Solanacol RsbQ-like Strigolactone receptors ligand Plant hormone Canonical strigolactone
Avenaol RsbQ-like Strigolactone receptors ligand Non-canonical strigolactone Plant hormone
Bryosymbiol RsbQ-like Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
MeCLA RsbQ-like Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
Cannalactone RsbQ-like Strigolactone Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
XM-47 RsbQ-like Naphthalen Strigolactone receptors ligand
2-methoxy-1-naphthaldehyde RsbQ-like Naphthalen Strigolactone receptors ligand
Carlactonoic-acid RsbQ-like Strigolactone receptors ligand Non-canonical strigolactone
Vibralactone Pancreatic_lipase Natural Lactone Lipase inhibitor
Vibralactone-derivative-Cpd1 Pancreatic_lipase Lactone Lipase inhibitor Carboxamide
RG6 RsbQ-like Strigolactone receptors ligand
Soporidine RsbQ-like Alkyne Piperidine Trifluoro Strigolactone receptors ligand
Germinone-A RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
dMgerminone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
4-CN-desmethyl-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand Cyanide
4-CN-Debranone RsbQ-like Strigolactone Debranone Cyanide Strigolactone receptors ligand
4-Cl-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand Organochlorine
4-Br-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
Rocaglate-Derived-beta-Lactone-5 ABHD10 Carboxypeptidase_S10 Acyl-CoA_Thioesterase Lactone Benzofuran
KK023-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK023-N2 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK094 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
7-carba-4BD-ring-opened RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
7-carba-4BD RsbQ-like Strigolactone Debranone Butenolide Strigolactone receptors ligand
Hydroxy-D-ring RsbQ-like Plant_carboxylesterase Butenolide Plant hormone Strigolactone receptors ligand Strigolactone Natural
Methyl-phenlactonoate-butenolide-3 RsbQ-like Methyl Phenlactonoate Strigolactone receptors ligand Butenolide Dihydrofuran
Methyl-phenlactonoate-butenolide-16 RsbQ-like Methyl Phenlactonoate Strigolactone receptors ligand Butenolide
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Indole Butenolide Phthalimido Dihydrofuran
5-Deoxystrigol RsbQ-like Plant hormone Strigolactone Strigolactone receptors ligand Natural Inden
GR24 RsbQ-like Fungal-D14-Strigolactone-R Plant_carboxylesterase Strigolactone Strigolactone receptors ligand Inden
3-benzyl-4-tridecyloxetan-2-one-trans5c Carb_B_Chordata abh_upf0017 ABHD12-PHARC ABHD16 Thioesterase Tridecyl Lactone Oxooxetan
CLIM RsbQ-like Natural Plant hormone Strigolactone receptors ligand
A1L2E RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
NPD14805 RsbQ-like Strigolactone receptors ligand Quinoline
KK181-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
Zaxinone RsbQ-like Natural Plant hormone Strigolactone receptors ligand
Solanacyl-acetate RsbQ-like Strigolactone receptors ligand Canonical strigolactone Plant hormone Acetate
Solanacol RsbQ-like Strigolactone receptors ligand Plant hormone Canonical strigolactone
Avenaol RsbQ-like Strigolactone receptors ligand Non-canonical strigolactone Plant hormone
Bryosymbiol RsbQ-like Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
MeCLA RsbQ-like Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
Cannalactone RsbQ-like Strigolactone Strigolactone receptors ligand Plant hormone Non-canonical strigolactone
XM-47 RsbQ-like Naphthalen Strigolactone receptors ligand
2-methoxy-1-naphthaldehyde RsbQ-like Naphthalen Strigolactone receptors ligand
Carlactonoic-acid RsbQ-like Strigolactone receptors ligand Non-canonical strigolactone
Vibralactone Pancreatic_lipase Natural Lactone Lipase inhibitor
Vibralactone-derivative-Cpd1 Pancreatic_lipase Lactone Lipase inhibitor Carboxamide
RG6 RsbQ-like Strigolactone receptors ligand
Soporidine RsbQ-like Alkyne Piperidine Trifluoro Strigolactone receptors ligand
Germinone-A RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
dMgerminone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
4-CN-desmethyl-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand Cyanide
4-CN-Debranone RsbQ-like Strigolactone Debranone Cyanide Strigolactone receptors ligand
4-Cl-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand Organochlorine
4-Br-Debranone RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
Rocaglate-Derived-beta-Lactone-5 ABHD10 Carboxypeptidase_S10 Acyl-CoA_Thioesterase Lactone Benzofuran
KK023-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK023-N2 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK094 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
7-carba-4BD-ring-opened RsbQ-like Strigolactone Debranone Strigolactone receptors ligand
7-carba-4BD RsbQ-like Strigolactone Debranone Butenolide Strigolactone receptors ligand
Hydroxy-D-ring RsbQ-like Plant_carboxylesterase Butenolide Plant hormone Strigolactone receptors ligand Strigolactone Natural
Methyl-phenlactonoate-butenolide-3 RsbQ-like Methyl Phenlactonoate Strigolactone receptors ligand Butenolide Dihydrofuran
Methyl-phenlactonoate-butenolide-16 RsbQ-like Methyl Phenlactonoate Strigolactone receptors ligand Butenolide
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Indole Butenolide Phthalimido Dihydrofuran