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Lipase inhibitor

General

Lipase inhibitors are substances used to reduce the activity of lipases found in the intestine. Lipases are secreted by the pancreas when fat is present. The primary role of lipase inhibitors is to decrease the gastrointestinal absorption of fats
Inhibitor Main targeted enzyme families Type Structure
4,6-dialkoxyaurone-cpd8 Pancreatic_lipase Flavonoid Benzofuran Lipase inhibitor Antioxidant
EZ120P A85-Mycolyl-transferase Oxooxetan Lipase inhibitor Alkyne
Cpd17-Pyrrolidine-THL-derivative Cutinase Oxooxetan Lipase inhibitor Pyrrolidine
EZ120 A85-Mycolyl-transferase Oxooxetan Lipase inhibitor
Tetrahydrolipstatin-alkyne Hormone-sensitive_lipase_like Oxooxetan Lipase inhibitor Alkyne
Lalistat-alkyne-probe Acidic_Lipase 6_AlphaBeta_hydrolase Cutinase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Piperidine Lipase inhibitor Sulfur Compound Thiadiazol Alkyne ABPP-Probe
Vibralactone Pancreatic_lipase Natural Lactone Lipase inhibitor
Vibralactone-derivative-Cpd1 Pancreatic_lipase Lactone Lipase inhibitor Carboxamide
Myricitrin-5-methyl-ether Acidic_Lipase Flavonoid Lipase inhibitor Chromen
L-Isoleucine-Orlistat Lipase_3 Oxooxetan Lipase inhibitor
O-3841 Lipase_3 Organophosphate Lipase inhibitor
Lalistat-1 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur Compound Thiadiazol
Lalistat-2 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur Compound Thiadiazol Carbamate
C6-C4-Sn3-phosphinate Hormone-sensitive_lipase_like Organophosphate Lipase inhibitor
C8-C4-Sn3-phosphinate Hormone-sensitive_lipase_like Organophosphate Lipase inhibitor
C12-myristoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate pNP Analogue of substrate Lipase inhibitor Azido Myristate Tetradecanoate
C14-palmitoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate pNP Lipase inhibitor Analogue of substrate Azido
C16-stearoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate Analogue of substrate Lipase inhibitor pNP Azido
C18-octadecyl-MAG-like-phosphonate Monoglyceridelipase_lysophospholip Organophosphate Analogue of substrate Lipase inhibitor pNP Azido
3-Cholesteryl-N-butylcarbamate Cholesterol_esterase Carbamate Steroid Phenanthrene Lipase inhibitor
3-Cholesteryl-N-octylcarbamate Cholesterol_esterase Carbamate Steroid Phenanthrene Lipase inhibitor
Esterastin Acidic_Lipase Pancreatic_lipase Oxooxetan Natural Lipase inhibitor
Lipstatin Pancreatic_lipase Oxooxetan Natural Lipase inhibitor
N-Hexylphosphonate-Ethyl-Ester Canar_LipB Lipase_3 Cutinase Hormone-sensitive_lipase_like Organophosphate Lipase inhibitor Organochlorine
C4-C4-SN3-tributyrin-phosphonate Hormone-sensitive_lipase_like Lipase inhibitor Organophosphate
C11Y4-phosphonate Cutinase Acidic_Lipase Organophosphate Lipase inhibitor
O-7460 Lipase_3 Organophosphate Analogue of substrate Lipase inhibitor Triacylglycerol
DSF LYsophospholipase_carboxylesterase Acidic_Lipase Sulfur Compound Sulfonyl NTE inhibitor Not AlphaBeta Hydrolase target Lipase inhibitor OPIDN-OP
CyC-31 Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor
CyC-31yne Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Alkyne
CyC-32 Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor
CyC-32yne Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Alkyne
CyC-31-open Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Cyclic OP open
Cyclophostin-enolphosphonate Cutinase Monoglyceridelipase_lysophospholip Organophosphate Cyclic OP Lipase inhibitor
Sal-A-alkyne Plasmodium_subtelomeric_PST-A ABHD13-BEM46 Duf_676 PGAP1 ABHD17-depalmitoylase Organophosphate Cyclic OP Lipase inhibitor ABPP-Probe Alkyne
Salinipostin-A Plasmodium_subtelomeric_PST-A ABHD13-BEM46 Duf_676 PGAP1 ABHD17-depalmitoylase Organophosphate Cyclic OP Lipase inhibitor Natural
Cyclipostin-P Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase Organophosphate Cyclic OP Lipase inhibitor Natural
CyC-17 A85-Mycolyl-transferase Hormone-sensitive_lipase_like Cutinase Carbon-carbon_bond_hydrolase Thioesterase Organophosphate Cyclic OP Lipase inhibitor
CyC-17-open A85-Mycolyl-transferase Organophosphate Cyclic OP open Lipase inhibitor
CyC-7beta A85-Mycolyl-transferase Organophosphate Cyclic OP Lipase inhibitor
CyC-7beta-open A85-Mycolyl-transferase Organophosphate Cyclic OP open Lipase inhibitor
CyC-8beta A85-Mycolyl-transferase Organophosphate Cyclic OP Lipase inhibitor
CyC-8beta-open A85-Mycolyl-transferase Organophosphate Cyclic OP open Lipase inhibitor
l,2-Dioctylcarbamoylglycero-3-O-p-nitrophenyloctylphosphonate Cutinase Bacterial_lip_FamI.6 Organophosphate Analogue of substrate Lipase inhibitor Triacylglycerol pNP
di-O-octylglycero-O-(p-nitrophenyl)-n-hexyl-phosphonate Bacterial_lip_FamI.2 Lipase_3 Analogue of substrate Lipase inhibitor Triacylglycerol Organophosphate pNP
Cetilistat Pancreatic_lipase Lipase inhibitor Benzoxazine Oxazine
bis-benzene-sulfonamide Carboxylesterase Carb_B_Chordata Lipase inhibitor Sulfur Compound Sulfonamide Benzenesulfonamide
MPOX Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor
MpPPOX Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor Phenoxyphenyl
MmPPOX Acidic_Lipase Hormone-sensitive_lipase_like ABHD16 Oxadiazolone Oxadiazol Lipase inhibitor Phenoxyphenyl
Metoxadiazone Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor
DBOX Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor Benzofuran
THL-10d A85-Mycolyl-transferase Oxooxetan Lipase inhibitor Benzyloxycarbonyl
Orlistat AlphaBeta_hydrolase Acidic_Lipase Pancreatic_lipase Thioesterase Carb_B_Chordata ABHD6-Lip Lipase_3 Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase ABHD16 A85-Mycolyl-transferase PE-PPE Plasmodium_subtelomeric_PST-A Bacterial_lip_FamI.6 Oxooxetan Lipase inhibitor
4,6-dialkoxyaurone-cpd8 Pancreatic_lipase Flavonoid Benzofuran Lipase inhibitor Antioxidant
EZ120P A85-Mycolyl-transferase Oxooxetan Lipase inhibitor Alkyne
Cpd17-Pyrrolidine-THL-derivative Cutinase Oxooxetan Lipase inhibitor Pyrrolidine
EZ120 A85-Mycolyl-transferase Oxooxetan Lipase inhibitor
Tetrahydrolipstatin-alkyne Hormone-sensitive_lipase_like Oxooxetan Lipase inhibitor Alkyne
Lalistat-alkyne-probe Acidic_Lipase 6_AlphaBeta_hydrolase Cutinase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Piperidine Lipase inhibitor Sulfur compound Thiadiazol Alkyne ABPP-Probe
Vibralactone Pancreatic_lipase Natural Lactone Lipase inhibitor
Vibralactone-derivative-Cpd1 Pancreatic_lipase Lactone Lipase inhibitor Carboxamide
Myricitrin-5-methyl-ether Acidic_Lipase Flavonoid Lipase inhibitor Chromen
L-Isoleucine-Orlistat Lipase_3 Oxooxetan Lipase inhibitor
O-3841 Lipase_3 Organophosphate Lipase inhibitor
Lalistat-1 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur compound Thiadiazol
Lalistat-2 Acidic_Lipase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase 6_AlphaBeta_hydrolase Piperidine Lipase inhibitor Sulfur compound Thiadiazol Carbamate
C6-C4-Sn3-phosphinate Hormone-sensitive_lipase_like Organophosphate Lipase inhibitor
C8-C4-Sn3-phosphinate Hormone-sensitive_lipase_like Organophosphate Lipase inhibitor
C12-myristoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate pNP Analogue of substrate Lipase inhibitor Azido Myristate Tetradecanoate
C14-palmitoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate pNP Lipase inhibitor Analogue of substrate Azido
C16-stearoyl-MAG-like-phosphonate CarbLipBact_2 Organophosphate Analogue of substrate Lipase inhibitor pNP Azido
C18-octadecyl-MAG-like-phosphonate Monoglyceridelipase_lysophospholip Organophosphate Analogue of substrate Lipase inhibitor pNP Azido
3-Cholesteryl-N-butylcarbamate Cholesterol_esterase Carbamate Steroid Phenanthrene Lipase inhibitor
3-Cholesteryl-N-octylcarbamate Cholesterol_esterase Carbamate Steroid Phenanthrene Lipase inhibitor
Esterastin Acidic_Lipase Pancreatic_lipase Oxooxetan Natural Lipase inhibitor
Lipstatin Pancreatic_lipase Oxooxetan Natural Lipase inhibitor
N-Hexylphosphonate-Ethyl-Ester Canar_LipB Lipase_3 Cutinase Hormone-sensitive_lipase_like Organophosphate Lipase inhibitor Organochlorine
C4-C4-SN3-tributyrin-phosphonate Hormone-sensitive_lipase_like Lipase inhibitor Organophosphate
C11Y4-phosphonate Cutinase Acidic_Lipase Organophosphate Lipase inhibitor
O-7460 Lipase_3 Organophosphate Analogue of substrate Lipase inhibitor Triacylglycerol
DSF LYsophospholipase_carboxylesterase Acidic_Lipase Sulfur compound Sulfonyl NTE inhibitor Not AlphaBeta Hydrolase target Lipase inhibitor OPIDN-OP
CyC-31 Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor
CyC-31yne Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Alkyne
CyC-32 Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor
CyC-32yne Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Alkyne
CyC-31-open Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Cyclic OP open
Cyclophostin-enolphosphonate Cutinase Monoglyceridelipase_lysophospholip Organophosphate Cyclic OP Lipase inhibitor
Sal-A-alkyne Plasmodium_subtelomeric_PST-A ABHD13-BEM46 Duf_676 PGAP1 ABHD17-depalmitoylase Organophosphate Cyclic OP Lipase inhibitor ABPP-Probe Alkyne
Salinipostin-A Plasmodium_subtelomeric_PST-A ABHD13-BEM46 Duf_676 PGAP1 ABHD17-depalmitoylase Organophosphate Cyclic OP Lipase inhibitor Natural
Cyclipostin-P Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase Organophosphate Cyclic OP Lipase inhibitor Natural
CyC-17 A85-Mycolyl-transferase Hormone-sensitive_lipase_like Cutinase Carbon-carbon_bond_hydrolase Thioesterase Organophosphate Cyclic OP Lipase inhibitor
CyC-17-open A85-Mycolyl-transferase Organophosphate Cyclic OP open Lipase inhibitor
CyC-7beta A85-Mycolyl-transferase Organophosphate Cyclic OP Lipase inhibitor
CyC-7beta-open A85-Mycolyl-transferase Organophosphate Cyclic OP open Lipase inhibitor
CyC-8beta A85-Mycolyl-transferase Organophosphate Cyclic OP Lipase inhibitor
CyC-8beta-open A85-Mycolyl-transferase Organophosphate Cyclic OP open Lipase inhibitor
l,2-Dioctylcarbamoylglycero-3-O-p-nitrophenyloctylphosphonate Cutinase Bacterial_lip_FamI.6 Organophosphate Analogue of substrate Lipase inhibitor Triacylglycerol pNP
di-O-octylglycero-O-(p-nitrophenyl)-n-hexyl-phosphonate Bacterial_lip_FamI.2 Lipase_3 Analogue of substrate Lipase inhibitor Triacylglycerol Organophosphate pNP
Cetilistat Pancreatic_lipase Lipase inhibitor Benzoxazine Oxazine
bis-benzene-sulfonamide Carboxylesterase Carb_B_Chordata Lipase inhibitor Sulfur compound Sulfonamide Benzenesulfonamide
MPOX Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor
MpPPOX Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor Phenoxyphenyl
MmPPOX Acidic_Lipase Hormone-sensitive_lipase_like ABHD16 Oxadiazolone Oxadiazol Lipase inhibitor Phenoxyphenyl
Metoxadiazone Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor
DBOX Acidic_Lipase Oxadiazolone Oxadiazol Lipase inhibitor Benzofuran
THL-10d A85-Mycolyl-transferase Oxooxetan Lipase inhibitor Benzyloxycarbonyl
Orlistat AlphaBeta_hydrolase Acidic_Lipase Pancreatic_lipase Thioesterase Carb_B_Chordata ABHD6-Lip Lipase_3 Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Cutinase ABHD16 A85-Mycolyl-transferase PE-PPE Plasmodium_subtelomeric_PST-A Bacterial_lip_FamI.6 Oxooxetan Lipase inhibitor