p-chloromercuribenzoic-acid
Alkylating reagent commonly used to irreversibly label cysteines in biomolecules. Covalent modification by iodoacetamide at Cys-209 of Ag85C inactivates the enzyme
General
Type : Thiol-reactive
Chemical_Nomenclature : (4-carboxyphenyl)-chloromercury
Canonical SMILES : C1=CC(=CC=C1C(=O)O)[Hg]Cl
InChI : InChI=1S\/C7H5O2.ClH.Hg\/c8-7(9)6-4-2-1-3-5-6\;\;\/h2-5H,(H,8,9)\;1H\;\/q\;\;+1\/p-1
InChIKey : YFZOUMNUDGGHIW-UHFFFAOYSA-M
Other name(s) : 4-chloromercuribenzoic acid || P-Chloromercuribenzoic acid || PCMB || p-chloromercuribenzoate || P-Chloromercurybenzoic acid || P-(chloromercuri)benzoic acid || P-Chloromercuric benzoic acid || Chloromercuribenzoate || E1LE0WZ4BO || p-Chloro-mercuric benzoic acid || EINECS 200-442-6 || AI3-15315 || (4-Carboxyphenyl)chloromercury
MW : 357.15
Formula : C7H5ClHgO2 || C7H4ClHgO2.H
CAS_number : 59-85-8
UniChem : YFZOUMNUDGGHIW-UHFFFAOYSA-M
Target
Families : p-chloromercuribenzoic-acid ligand of proteins in family
A85-Mycolyl-transferase
CMBL
Structure :
4QDO
Protein :
myctu-a85c
human-CMBL
References (5)
| Title : Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors - Favrot_2014_J.Biol.Chem_289_25031 |
| Author(s) : Favrot L , Lajiness DH , Ronning DR |
| Ref : Journal of Biological Chemistry , 289 :25031 , 2014 |
| Abstract : |
| PubMedSearch : Favrot_2014_J.Biol.Chem_289_25031 |
| PubMedID: 25028518 |
| Gene_locus related to this paper: myctu-a85c |
| Title : The effects of p-chloromercuribenzoate on muscarinic receptors in the cerebral cortex - Birdsall_1983_Br.J.Pharmacol_80_187 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wong EH |
| Ref : British Journal of Pharmacology , 80 :187 , 1983 |
| Abstract : |
| PubMedSearch : Birdsall_1983_Br.J.Pharmacol_80_187 |
| PubMedID: 6652369 |
| Title : The effect of p-chloromercuribenzoate on structure-binding relationships of muscarinic receptors in the rat cerebral cortex - Birdsall_1983_Br.J.Pharmacol_80_197 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wong EH |
| Ref : British Journal of Pharmacology , 80 :197 , 1983 |
| Abstract : |
| PubMedSearch : Birdsall_1983_Br.J.Pharmacol_80_197 |
| PubMedID: 6652370 |
| Title : Esterase-16 (es-16): characterization, polymorphism, and linkage to chromosome 3 of a kidney esterase locus of the house mouse - von Deimling_1981_Biochem.Genet_19_1091 |
| Author(s) : von Deimling OH , Schupp P , Otto J |
| Ref : Biochemical Genetics , 19 :1091 , 1981 |
| Abstract : |
| PubMedSearch : von Deimling_1981_Biochem.Genet_19_1091 |
| PubMedID: 7337689 |
| Title : Effects of p-chloromercuribenzoate on muscarinic receptor binding in rat brain [proceedings] - |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wong EH |
| Ref : British Journal of Pharmacology , 68 :142P , 1980 |
| PubMedID: 7357157 |