(from Interpro) Carboxymethylenebutenolidase (CMBL) is a human homologue of Pseudomonas dienelactone hydrolase involved in the bacterial halocatechol degradation pathway. It is a cysteine hydrolase that can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Not inhibited by DFP, PMSF, eserine or EDTA. Strongly inhibited by p-chloromercuribenzoate (PCMB). This entry also includes uncharacterised DLH domain-containing proteins from plants. This family was previously included in Dienelactone_hydrolase
Interpro : IPR042946 Carboxymethylenebutenolidase homolog
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
No structure scheme yet for this family
Genes Proteins in CMBL family (251)
Fragments of genes in CMBL family (32)
No fragment of genesSubstrates in CMBL family (2)
No Inhibitor
Title : Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine - Ishizuka_2013_Drug.Metab.Dispos_41_1156 |
Author(s) : Ishizuka T , Rozehnal V , Fischer T , Kato A , Endo S , Yoshigae Y , Kurihara A , Izumi T |
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1156 , 2013 |
Abstract : Ishizuka_2013_Drug.Metab.Dispos_41_1156 |
ESTHER : Ishizuka_2013_Drug.Metab.Dispos_41_1156 |
PubMedSearch : Ishizuka_2013_Drug.Metab.Dispos_41_1156 |
PubMedID: 23471504 |
Gene_locus related to this paper: human-CMBL |
Title : Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine - Ishizuka_2010_J.Biol.Chem_285_11892 |
Author(s) : Ishizuka T , Fujimori I , Kato M , Noji-Sakikawa C , Saito M , Yoshigae Y , Kubota K , Kurihara A , Izumi T , Ikeda T , Okazaki O |
Ref : Journal of Biological Chemistry , 285 :11892 , 2010 |
Abstract : Ishizuka_2010_J.Biol.Chem_285_11892 |
ESTHER : Ishizuka_2010_J.Biol.Chem_285_11892 |
PubMedSearch : Ishizuka_2010_J.Biol.Chem_285_11892 |
PubMedID: 20177059 |
Gene_locus related to this paper: human-CMBL |