CMBL

Relationship

Family: CMBL

Block: X

Parent Family: No family

Comment

(from Interpro) Carboxymethylenebutenolidase (CMBL) is a human homologue of Pseudomonas dienelactone hydrolase involved in the bacterial halocatechol degradation pathway. It is a cysteine hydrolase that can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Not inhibited by DFP, PMSF, eserine or EDTA. Strongly inhibited by p-chloromercuribenzoate (PCMB). This entry also includes uncharacterised DLH domain-containing proteins from plants. This family was previously included in Dienelactone_hydrolase

Database

Interpro : IPR042946 Carboxymethylenebutenolidase homolog

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Gene_locus Name Species
9aves-a0a091fjn9 Cuculus canorus (common cuckoo). Carboxymethylenebutenolidase Cuculus canorus
9aves-a0a091fnm0 Cuculus canorus (common cuckoo). Carboxymethylenebutenolidase Cuculus canorus
9aves-a0a093c392 Pterocles gutturalis (yellow-throated sandgrouse). Carboxymethylenebutenolidase Pterocles gutturalis
9aves-a0a093ckc2 Pterocles gutturalis (yellow-throated sandgrouse). Carboxymethylenebutenolidase Pterocles gutturalis
9cich-a0a3b4esc0 Pundamilia nyererei. Carboxymethylenebutenolidase homolog (Pseudomonas) Pundamilia nyererei
9cich-a0a3p9d359 Maylandia zebra (zebra mbuna). Carboxymethylenebutenolidase homolog (Pseudomonas) Maylandia zebra
9gobi-a0a3b4b6y7 Periophthalmus magnuspinnatus. Carboxymethylenebutenolidase homolog (Pseudomonas) Periophthalmus magnuspinnatus
9grui-a0a091kme5 Chlamydotis macqueenii (Macqueen's bustard). Carboxymethylenebutenolidase Chlamydotis macqueenii
9grui-a0a091re20 Mesitornis unicolor (brown roatelo). Carboxymethylenebutenolidase Mesitornis unicolor
9grui-a0a091rr12 Mesitornis unicolor (brown roatelo). Carboxymethylenebutenolidase Mesitornis unicolor
9labr-a0a3q3fda5 Labrus bergylta (ballan wrasse). Carboxymethylenebutenolidase homolog (Pseudomonas) Labrus bergylta
9pase-a0a218uhi4 Lonchura striata domestica (Bengalese finch). Carboxymethylenebutenolidase Lonchura striata domestica
9pass-a0a091mls7 Acanthisitta chloris (rifleman). Carboxymethylenebutenolidase Acanthisitta chloris
9pass-a0a093pui8 Manacus vitellinus (golden-collared manakin). Carboxymethylenebutenolidase Manacus vitellinus
9pass-a0a093q7b3 Manacus vitellinus (golden-collared manakin). Carboxymethylenebutenolidase Manacus vitellinus
9poal-a0a1e5vve9 Dichanthelium oligosanthes. DLH domain-containing protein Dichanthelium oligosanthes
9poal-a0a2s3hbt0 Panicum hallii\; Panicum hallii var. hallii\; Panicum miliaceum (Proso millet) (Broomcorn millet). DLH domain-containing protein Panicum hallii
9saur-a0a402ft50 Paroedura picta. DLH domain-containing protein Paroedura picta
9saur-a0a402ft99 Paroedura picta. DLH domain-containing protein Paroedura picta
9saur-a0a452hm23 Gopherus agassizii (Agassiz's desert tortoise). DLH domain-containing protein Gopherus agassizii
9saur-a0a4d9e0s9 Platysternon megacephalum (big-headed turtle). Carboxymethylenebutenolidase-like protein Platysternon megacephalum
9tele-a0a1a7wn71 Iconisemion striatum. Carboxymethylenebutenolidase-like (Pseudomonas) Iconisemion striatum
9tele-a0a2i4aqp9 Austrofundulus limnaeus. carboxymethylenebutenolidase homolog Austrofundulus limnaeus
9tele-a0a3b3rr42 Paramormyrops kingsleyae. Carboxymethylenebutenolidase homolog (Pseudomonas) Paramormyrops kingsleyae
9tele-a0a3b3v917 Poecilia latipinna (sailfin molly). Carboxymethylenebutenolidase homolog (Pseudomonas) Poecilia latipinna
9tele-a0a3b5aqx2 Stegastes partitus (bicolor damselfish). Carboxymethylenebutenolidase homolog (Pseudomonas) Stegastes partitus
9tele-a0a3b5lh80 Xiphophorus couchianus (Monterrey platyfish). Carboxymethylenebutenolidase homolog (Pseudomonas) Xiphophorus couchianus
9tele-a0a3q1glr8 Acanthochromis polyacanthus (spiny chromis). Carboxymethylenebutenolidase homolog (Pseudomonas) Acanthochromis polyacanthus
9tele-a0a3q3ndv7 Mastacembelus armatus (zig-zag eel). Carboxymethylenebutenolidase homolog (Pseudomonas) Mastacembelus armatus
ailme-d2h9w7 Ailuropoda melanoleuca (Giant panda). Carboxymethylenebutenolidase homolog Ailuropoda melanoleuca
allmi-a0a151phf3 Alligator mississippiensis (American alligator)\; Alligator sinensis (Chinese alligator). Carboxymethylenebutenolidase-like protein Alligator mississippiensis
allsi-a0a1u7rrg3 Alligator sinensis (Chinese alligator)\; Alligator mississippiensis (American alligator). carboxymethylenebutenolidase homolog isoform X1 Alligator sinensis
allsi-a0a1u8cvq6 Alligator sinensis (Chinese alligator)\; Alligator mississippiensis (American alligator). carboxymethylenebutenolidase homolog Alligator sinensis
amaae-a0a0q3pfk6 Amazona aestiva (Blue-fronted Amazon parrot). Carboxymethylenebutenolidase Amazona aestiva
ampci-a0a3q0qv51 Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum). Carboxymethylenebutenolidase homolog (Pseudomonas) Amphilophus citrinellus
amppe-a0a3p8u449 Amphiprion percula (Orange clownfish) (Lutjanus percula)\; Amphiprion ocellaris (Clown anemonefish). Carboxymethylenebutenolidase homolog (Pseudomonas) Amphiprion percula
anapl-r0ktn0 Anas platyrhynchos (Mallard) (Anas boschas)\; Anas platyrhynchos platyrhynchos (Northern mallard). Carboxymethylenebutenolidase-like protein Anas platyrhynchos
anapl-r0l8l1 Anas platyrhynchos (Mallard) (Anas boschas)\; Anas platyrhynchos platyrhynchos (Northern mallard). Carboxymethylenebutenolidase-like protein Anas platyrhynchos
anate-a0a3q1jxa4 Anabas testudineus (Climbing perch) (Anthias testudineus). Carboxymethylenebutenolidase homolog (Pseudomonas) Anabas testudineus
anoca-g1kaz5 Anolis carolinensis (Green anole) (American chameleon). Carboxymethylenebutenolidase homolog Anolis carolinensis
antcr-a0a094k2s1 Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis). Carboxymethylenebutenolidase Antrostomus carolinensis
antcr-a0a094nax2 Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis). Carboxymethylenebutenolidase Antrostomus carolinensis
aotna-a0a2k5dtp7 Aotus nancymaae (Ma's night monkey). Carboxymethylenebutenolidase homolog Aotus nancymaae
apavi-a0a091mye1 Apaloderma vittatum (Bar-tailed trogon). Carboxymethylenebutenolidase Apaloderma vittatum
apavi-a0a091n0s0 Apaloderma vittatum (Bar-tailed trogon)\; Cariama cristata (Red-legged seriema). Carboxymethylenebutenolidase Apaloderma vittatum
aptfo-a0a087qxk5 Aptenodytes forsteri (Emperor penguin)\; Pygoscelis adeliae (Adelie penguin). Carboxymethylenebutenolidase Aptenodytes forsteri
aptfo-a0a087qxk7 Aptenodytes forsteri (Emperor penguin). Carboxymethylenebutenolidase Aptenodytes forsteri
arath-F12A4.4 Arabidopsis thaliana (Mouse-ear cress)\; Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Carboxymethylenebutenolidase homolog Arabidopsis thaliana
arudo-a0a0a9sxb7 Arundo donax (Giant reed) (Donax arundinaceus). DLH domain-containing protein Arundo donax
astca-a0a3p8qxp7 Astatotilapia calliptera (Eastern happy) (Chromis callipterus). Carboxymethylenebutenolidase homolog (Pseudomonas) Astatotilapia calliptera
astmx-w5ln33 Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Carboxymethylenebutenolidase homolog (Pseudomonas) Astyanax mexicanus
balas-a0a384alv8 Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni). carboxymethylenebutenolidase homolog Balaenoptera acutorostrata scammoni
balre-a0a087vbc4 Balearica regulorum gibbericeps (East African grey crowned-crane). Carboxymethylenebutenolidase Balearica regulorum gibbericeps
balre-a0a087vbc5 Balearica regulorum gibbericeps (East African grey crowned-crane). Carboxymethylenebutenolidase Balearica regulorum gibbericeps
bamth-a0a2p4tbd7 Bambusicola thoracicus (Chinese bamboo-partridge) (Perdix thoracica). DLH domain-containing protein Bambusicola thoracicus
bovin-f1n2i5 Bos taurus (Bovine)\; Bos indicus x Bos taurus (Hybrid cattle)\; Bos mutus (wild yak). Carboxymethylenebutenolidase homolog Bos taurus
bradi-a0a0q3mph9 Brachypodium distachyon (Purple false brome) (Trachynia distachya). DLH domain-containing protein Brachypodium distachyon
brafl-c3yde6 Branchiostoma floridae (Florida lancelet) (Amphioxus). DLH domain-containing protein Branchiostoma floridae
brarp-m4eh17 Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis)\; Brassica campestris (Field mustard). DLH domain-containing protein Brassica rapa subsp. pekinensis
bucrh-a0a091h0a8 Buceros rhinoceros silvestris. Carboxymethylenebutenolidase Buceros rhinoceros silvestris
bucrh-a0a091h376 Buceros rhinoceros silvestris. Carboxymethylenebutenolidase Buceros rhinoceros silvestris
calan-a0a091hrs7 Calypte anna (Anna's hummingbird) (Archilochus anna). Carboxymethylenebutenolidase Calypte anna
calan-a0a091hv38 Calypte anna (Anna's hummingbird) (Archilochus anna). Carboxymethylenebutenolidase Calypte anna
calja-u3dfd0 Callithrix jacchus (White-tufted-ear marmoset). Carboxymethylenebutenolidase homolog Callithrix jacchus
calsu-a0a226nd24 Callipepla squamata (Scaled quail). DLH domain-containing protein Callipepla squamata
calur-a0a3q7nnm2 Callorhinus ursinus (Northern fur seal). carboxymethylenebutenolidase homolog Callorhinus ursinus
camfr-s9xmm4 Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus). Carboxymethylenebutenolidase-like protein Camelus ferus
canlf-e2rf91 Canis lupus familiaris (Dog) (Canis familiaris). Carboxymethylenebutenolidase homolog Canis lupus familiaris
caphi-a0a452fu67 Capra hircus (Goat). Carboxymethylenebutenolidase homolog Capra hircus
catau-a0a091l7g8 Cathartes aura (Turkey vulture) (Vultur aura). Carboxymethylenebutenolidase Cathartes aura
catau-a0a091laq9 Cathartes aura (Turkey vulture) (Vultur aura). Carboxymethylenebutenolidase Cathartes aura
catau-a0a091lxv2 Cathartes aura (Turkey vulture) (Vultur aura). Carboxymethylenebutenolidase Cathartes aura
cavpo-h0uxk7 Cavia porcellus (Guinea pig). Carboxymethylenebutenolidase homolog Cavia porcellus
cebca-a0a2k5pvg2 Cebus capucinus imitator. Carboxymethylenebutenolidase homolog Cebus capucinus imitator
cerat-a0a2k5m4u0 Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys). Carboxymethylenebutenolidase homolog Cercocebus atys
chabu-a0a388jwy2 Chara braunii (Braun's stonewort). DLH domain-containing protein Chara braunii
chavo-a0a0a0acj7 Charadrius vociferus (Killdeer) (Aegialitis vocifera). Carboxymethylenebutenolidase Charadrius vociferus
chavo-a0a0a0afk6 Charadrius vociferus (Killdeer) (Aegialitis vocifera). Carboxymethylenebutenolidase Charadrius vociferus
chavo-a0a0a0agv7 Charadrius vociferus (Killdeer) (Aegialitis vocifera). Carboxymethylenebutenolidase Charadrius vociferus
chemy-m7bzy6 Chelonia mydas (Green sea-turtle) (Chelonia agassizi)Gopherus agassizii (Agassiz's desert tortoise). Carboxymethylenebutenolidase like protein Chelonia mydas
chick-a0a1d5nwc0 Gallus gallus (Chicken). DLH domain-containing protein Gallus gallus
chick-e1bxs8 Gallus gallus (Chicken)\; Bambusicola thoracicus (Chinese bamboo-partridge) (Perdix thoracica). Carboxymethylenebutenolidase homolog Gallus gallus
chlgu-a0a3l8s7u5 Chloebia gouldiae (Gouldian finch) (Erythrura gouldiae). DLH domain-containing protein Chloebia gouldiae
chlgu-a0a3l8s7w7 Chloebia gouldiae (Gouldian finch) (Erythrura gouldiae). DLH domain-containing protein Chloebia gouldiae
chlsb-a0a0d9rxl6 Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus). Carboxymethylenebutenolidase homolog Chlorocebus sabaeus
chocr-r7qf11 Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa). DLH domain-containing protein Chondrus crispus
colli-a0a2i0mwb1 Columba livia (Rock dove)\; Cariama cristata (Red-legged seriema). Carboxymethylenebutenolidase homolog Columba livia
colli-a0a2i0mwb4 Columba livia (Rock dove). Carboxymethylenebutenolidase homolog, transcript variant X3 Columba livia
colli-a0a2i0mwd0 Columba livia (Rock dove). Carboxymethylenebutenolidase homolog Columba livia
colvi-a0a226nst0 Colinus virginianus (Northern bobwhite) (Tetrao virginianus). DLH domain-containing protein Colinus virginianus
corbr-a0a091exu8 Corvus brachyrhynchos (American crow). Carboxymethylenebutenolidase Corvus brachyrhynchos
crigr-g3h7k6 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). Carboxymethylenebutenolidase-like Cricetulus griseus
croad-a0a0f7zci7 Crotalus adamanteus (Eastern diamondback rattlesnake). Carboxymethylenebutenolidase homolog isoform X2 Crotalus adamanteus
cynse-a0a3p8vmz4 Cynoglossus semilaevis (Tongue sole). Carboxymethylenebutenolidase homolog (Pseudomonas) Cynoglossus semilaevis
cypva-a0a3q2dtg9 Cyprinodon variegatus (Sheepshead minnow). Carboxymethylenebutenolidase homolog (Pseudomonas) Cyprinodon variegatus
danre-a7mbu9 Danio rerio (Zebrafish) (Brachydanio rerio). Zgc:171683 protein Danio rerio
delle-a0a2y9npm7 Delphinapterus leucas (Beluga whale). carboxymethylenebutenolidase homolog Delphinapterus leucas
desro-k9iwy1 Desmodus rotundus (Vampire bat). Putative carboxymethylenebutenolidase Desmodus rotundus
dicla-e6zik3 Dicentrarchus labrax (European seabass) (Morone labrax). Carboxymethylenebutenolidase homolog Dicentrarchus labrax
dipor-a0a1s3ezh8 Dipodomys ordii (Ord's kangaroo rat). carboxymethylenebutenolidase homolog Dipodomys ordii
drypu-a0a093ghv3 Dryobates pubescens (Downy woodpecker) (Picoides pubescens). Carboxymethylenebutenolidase Dryobates pubescens
drypu-a0a093iih7 Dryobates pubescens (Downy woodpecker) (Picoides pubescens). Carboxymethylenebutenolidase Dryobates pubescens
echgr-a0a068wl60 Echinococcus granulosus (Hydatid tapeworm)\; Echinococcus multilocularis (Fox tapeworm). Carboxymethylenebutenolidase Echinococcus granulosus
egrga-a0a091j4p0 Egretta garzetta (Little egret). Carboxymethylenebutenolidase Egretta garzetta
egrga-a0a091j5p1 Egretta garzetta (Little egret). Carboxymethylenebutenolidase Egretta garzetta
egrga-a0a091j7y2 Egretta garzetta (Little egret). Carboxymethylenebutenolidase Egretta garzetta
eleel-a0a4w4dt57 Electrophorus electricus (Electric eel) (Gymnotus electricus). DLH domain-containing protein Electrophorus electricus
enhlu-a0a2y9k3r8 Enhydra lutris kenyoni. carboxymethylenebutenolidase homolog Enhydra lutris kenyoni
erieu-a0a1s2ztm3 Erinaceus europaeus (Western European hedgehog). carboxymethylenebutenolidase homolog isoform X1 Erinaceus europaeus
esolu-c1bwh0 Esox lucius (Northern pike). Carboxymethylenebutenolidase homolog Esox lucius
eurhl-a0a093lep2 Eurypyga helias (Sunbittern). Carboxymethylenebutenolidase Eurypyga helias
felca-m3x3u3 Felis catus (Cat) (Felis silvestris catus)\; Lynx pardinus (Iberian lynx) (Felis pardina). Carboxymethylenebutenolidase homolog Felis catus
fical-u3jze4 Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). DLH domain-containing protein Ficedula albicollis
fical-u3jze6 Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis)\; Corvus brachyrhynchos (American crow). DLH domain-containing protein Ficedula albicollis
fulga-a0a093je84 Fulmarus glacialis (Northern fulmar). Carboxymethylenebutenolidase Fulmarus glacialis
fulga-a0a093lsp8 Fulmarus glacialis (Northern fulmar). Carboxymethylenebutenolidase Fulmarus glacialis
gamaf-a0a315v4u9 Gambusia affinis (Western mosquitofish) (Heterandria affinis). DLH domain-containing protein Gambusia affinis
gasac-g3ndq5 Gasterosteus aculeatus (Three-spined stickleback). Carboxymethylenebutenolidase homolog (Pseudomonas) Gasterosteus aculeatus
gavst-a0a093fsd4 Gavia stellata (Red-throated diver) (Red-throated loon). Carboxymethylenebutenolidase Gavia stellata
gavst-a0a093hrp8 Gavia stellata (Red-throated diver) (Red-throated loon). Carboxymethylenebutenolidase Gavia stellata
glyso-a0a445l5n1 Glycine soja (Wild soybean)\; Glycine max (Soybean) (Glycine hispida). Carboxymethylenebutenolidase-like Glycine soja
gorgo-g3re16 Gorilla gorilla gorilla (Western lowland gorilla). Carboxymethylenebutenolidase homolog Gorilla gorilla gorilla
gulgu-a0a3p4r9i5 Gulo gulo (Wolverine) (Gluton). DLH domain-containing protein Gulo gulo
halal-a0a091nv48 Haliaeetus albicilla (White-tailed sea-eagle). Carboxymethylenebutenolidase Haliaeetus albicilla
halal-a0a091pmt3 Haliaeetus albicilla (White-tailed sea-eagle). Carboxymethylenebutenolidase Haliaeetus albicilla
halal-a0a091qip5 Haliaeetus albicilla (White-tailed sea-eagle). Carboxymethylenebutenolidase Haliaeetus albicilla
hapbu-a0a3q2xex4 Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni). Carboxymethylenebutenolidase homolog (Pseudomonas) Haplochromis burtoni
hetga-g5b709 Heterocephalus glaber (Naked mole rat). Carboxymethylenebutenolidase-like protein Heterocephalus glaber
hipcm-a0a3q3dyl2 Hippocampus comes (Tiger tail seahorse). Carboxymethylenebutenolidase homolog (Pseudomonas) Hippocampus comes
hirru-a0a3m0krg5 Hirundo rustica rustica. DLH domain-containing protein Hirundo rustica rustica
horse-f6ul42 Equus caballus (Horse). Carboxymethylenebutenolidase homolog Equus caballus
horvv-a0a287g9l8 Hordeum vulgare subsp. vulgare (Domesticated barley). DLH domain-containing protein Hordeum vulgare subsp. vulgare
human-CMBL Homo sapiens (Human) Carboxymethylenebutenolidase homolog Homo sapiens
hymdi-a0a0r3sdg0 Hymenolepis diminuta (Rat tapeworm). Uncharacterized protein Hymenolepis diminuta
hymnn-a0a0r3tns9 Hymenolepis nana (Dwarf tapeworm) (Rodentolepis nana). Uncharacterized protein Hymenolepis nana
ictpu-a0a2d0pnc6 Ictalurus punctatus (Channel catfish) (Silurus punctatus). carboxymethylenebutenolidase homolog Ictalurus punctatus
icttr-i3mzw6 Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus). Carboxymethylenebutenolidase homolog Ictidomys tridecemlineatus
kryma-a0a3q3arn3 Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus). Carboxymethylenebutenolidase homolog (Pseudomonas) Kryptolebias marmoratus
labro-a0a498ljp4 Labeo rohita (Indian major carp) (Cyprinus rohita). Carboxymethylenebutenolidase-like protein Labeo rohita
larcr-a0a0f8af44 Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea)\; Collichthys lucidus (Big head croaker) (Sciaena lucida). Carboxymethylenebutenolidase Larimichthys crocea
latca-a0a4w6ckk2 Lates calcarifer (Barramundi) (Holocentrus calcarifer). DLH domain-containing protein Lates calcarifer
lepdc-a0a091pjy3 Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor). Carboxymethylenebutenolidase Leptosomus discolor
lepdc-a0a091qcf4 Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor). Carboxymethylenebutenolidase Leptosomus discolor
lepoc-w5n7u0 Lepisosteus oculatus (Spotted gar). Carboxymethylenebutenolidase homolog (Pseudomonas) Lepisosteus oculatus
lepwe-a0a2u3yb76 Leptonychotes weddellii (Weddell seal) (Otaria weddellii). carboxymethylenebutenolidase homolog Leptonychotes weddellii
limla-a0a2i0urg8 Limosa lapponica baueri. DLH domain-containing protein Limosa lapponica baueri
limla-a0a2i0urh2 Limosa lapponica baueri. DLH domain-containing protein Limosa lapponica baueri
limla-a0a2i0uri0 Limosa lapponica baueri. DLH domain-containing protein Limosa lapponica baueri
lipve-a0a340x597 Lipotes vexillifer (Yangtze river dolphin). carboxymethylenebutenolidase homolog Lipotes vexillifer
litct-a0a2g9sm06 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana). DLH domain-containing protein Lithobates catesbeiana
macfa-a0a2k5tui1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Carboxymethylenebutenolidase-like protein Macaca fascicularis
macmu-f7gkb9 Macaca mulatta (Rhesus macaque). Carboxymethylenebutenolidase-like protein Macaca mulatta
macne-a0a2k6avr9 Macaca nemestrina (Pig-tailed macaque). Carboxymethylenebutenolidase homolog Macaca nemestrina
maize-b4fv80 Zea mays (Maize). Carboxymethylenebutenolidase Zea mays
manle-a0a2k5y121 Mandrillus leucophaeus (Drill) (Papio leucophaeus). Carboxymethylenebutenolidase homolog Mandrillus leucophaeus
medtr-q1t171 Medicago truncatula (Barrel medic) (Medicago tribuloides) . Carboxymethylenebutenolidase homolog Medicago truncatula
melga-g1n332 Meleagris gallopavo (Wild turkey). Carboxymethylenebutenolidase homolog Meleagris gallopavo
mernu-a0a091r5k1 Merops nubicus (Northern carmine bee-eater). Carboxymethylenebutenolidase Merops nubicus
mesau-a0a1u7qdv0 Mesocricetus auratus (Golden hamster). carboxymethylenebutenolidase homolog Mesocricetus auratus
molml-a0a3q4ak75 Mola mola (Ocean sunfish) (Tetraodon mola). Carboxymethylenebutenolidase homolog (Pseudomonas) Mola mola
monal-a0a3q3j994 Monopterus albus (Swamp eel). Carboxymethylenebutenolidase homolog (Pseudomonas) Monopterus albus
mondo-f7gd97 Monodelphis domestica (Gray short-tailed opossum). Carboxymethylenebutenolidase homolog Monodelphis domestica
monmo-a0a4u1fcm7 Monodon monoceros (Narwhal) (Ceratodon monodon). DLH domain-containing protein Monodon monoceros
mouse-CMBL Mus musculus (Mouse) Carboxymethylenebutenolidase homolog Mus musculus
mucpr-a0a371ghh2 Mucuna pruriens (Velvet bean) (Dolichos pruriens). Carboxymethylenebutenolidase-like protein Mucuna pruriens
muspf-m1ejz6 Mustela putorius furo (European domestic ferret) (Mustela furo). Carboxymethylenebutenolidase-like protein Mustela putorius furo
myolu-g1q4e3 Myotis lucifugus (Little brown bat)\; Myotis davidii (David's myotis)\; Myotis brandtii (Brandt's bat). Carboxymethylenebutenolidase homolog Myotis lucifugus
neoaa-a0a341d7e6 Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) (Neophocaena phocaenoides subsp. asiaeorientalis). carboxymethylenebutenolidase homolog Neophocaena asiaeorientalis asiaeorientalis
neole-a0a1a6ggj0 Neotoma lepida (Desert woodrat). DLH domain-containing protein Neotoma lepida
neosc-a0a2y9i2i8 Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi). carboxymethylenebutenolidase homolog Neomonachus schauinslandi
nesno-a0a091rrr8 Nestor notabilis (Kea). Carboxymethylenebutenolidase Nestor notabilis
nipni-a0a091vp10 Nipponia nippon (Crested ibis) (Ibis nippon). Carboxymethylenebutenolidase Nipponia nippon
nipni-a0a091vqk8 Nipponia nippon (Crested ibis) (Ibis nippon). Carboxymethylenebutenolidase Nipponia nippon
nipni-a0a091vr80 Nipponia nippon (Crested ibis) (Ibis nippon). Carboxymethylenebutenolidase Nipponia nippon
nomle-g1rlj6 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys). Carboxymethylenebutenolidase homolog Nomascus leucogenys
notfu-a0a1a8awg6 Nothobranchius furzeri (Turquoise killifish)\; Nothobranchius kadleci\; Nothobranchius kuhntae (Beira killifish)\; Nothobranchius pienaari\; Nothobranchius rachovii (bluefin notho)\; Nothobranchius korthausae. Carboxymethylenebutenolidase-like (Pseudomonas) Nothobranchius furzeri
odoro-a0a2u3wyy0 Odobenus rosmarus divergens (Pacific walrus). carboxymethylenebutenolidase homolog Odobenus rosmarus divergens
oncmy-a0a060y6u5 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). DLH domain-containing protein Oncorhynchus mykiss
ophha-v8pbf0.2 Ophiophagus hannah (King cobra) (Naja hannah). Carboxymethylenebutenolidase-like protein Ophiophagus hannah
opiho-a0a091wk90 Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). Carboxymethylenebutenolidase Opisthocomus hoazin
opiho-a0a091wm79 Opisthocomus hoazin (Hoatzin) (Phasianus hoazin). Carboxymethylenebutenolidase Opisthocomus hoazin
oreni-i3kaa3 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). Carboxymethylenebutenolidase homolog (Pseudomonas) Oreochromis niloticus
ornan-f6z9u4 Ornithorhynchus anatinus (Duckbill platypus). Carboxymethylenebutenolidase homolog Ornithorhynchus anatinus
oryja-a0a3s2p6v2 Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus). DLH domain-containing protein Oryzias javanicus
oryla-a0a3p9jla3 Oryzias latipes (Japanese rice fish) (Japanese killifish). Carboxymethylenebutenolidase homolog (Pseudomonas) Oryzias latipes
oryme-a0a3b3c014 Oryzias melastigma (Marine medaka). Carboxymethylenebutenolidase homolog (Pseudomonas) Oryzias melastigma
otoga-h0xgd9 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). Carboxymethylenebutenolidase homolog Otolemur garnettii
panmi-a0a3l6sxg5 Panicum miliaceum (Proso millet) (Broomcorn millet). DLH domain-containing protein Panicum miliaceum
panpa-a0a2r9aqr5 Pan paniscus (Pygmy chimpanzee) (Bonobo). Carboxymethylenebutenolidase homolog Pan paniscus
pantr-k7cfw7 Pan troglodytes (Chimpanzee). Carboxymethylenebutenolidase homolog Pan troglodytes
papan-a0a096msn0 Papio anubis (Olive baboon)\; Colobus angolensis palliatus (Peters' Angolan colobus). Carboxymethylenebutenolidase homolog Papio anubis
pelcr-a0a091ss46 Pelecanus crispus (Dalmatian pelican). Carboxymethylenebutenolidase Pelecanus crispus
pelcr-a0a091sy72 Pelecanus crispus (Dalmatian pelican). Carboxymethylenebutenolidase Pelecanus crispus
pelcr-a0a091tyr8 Pelecanus crispus (Dalmatian pelican). Carboxymethylenebutenolidase Pelecanus crispus
pelsi-k7fma0 Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). DLH domain-containing protein Pelodiscus sinensis
pelsi-k7fn69 Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). DLH domain-containing protein Pelodiscus sinensis
perfv-a0a484c6d1 Perca flavescens (American yellow perch) (Morone flavescens). DLH domain-containing protein Perca flavescens
petma-s4rrh1 Petromyzon marinus (Sea lamprey). Carboxymethylenebutenolidase homolog (Pseudomonas) Petromyzon marinus
phaan-a0a0l9ujf5 Phaseolus angularis (Azuki bean) (Vigna angularis)\; Vigna unguiculata (Cowpea)\; Vigna radiata var. radiata (Mung bean) (Phaseolus aureus). DLH domain-containing protein Phaseolus angularis
phaca-a0a093r054 Phalacrocorax carbo (Great cormorant) (Pelecanus carbo). Carboxymethylenebutenolidase Phalacrocorax carbo
phaca-a0a093r6a4 Phalacrocorax carbo (Great cormorant) (Pelecanus carbo). Carboxymethylenebutenolidase Phalacrocorax carbo
phaca-a0a093rdp2 Phalacrocorax carbo (Great cormorant) (Pelecanus carbo). Carboxymethylenebutenolidase Phalacrocorax carbo
phalp-a0a091tct8 Phaethon lepturus (White-tailed tropicbird). Carboxymethylenebutenolidase Phaethon lepturus
phavu-v7bu69 Phaseolus vulgaris (Kidney bean) (French bean). DLH domain-containing protein Phaseolus vulgaris
phorb-a0a091u2q1 Phoenicopterus ruber ruber. Carboxymethylenebutenolidase Phoenicopterus ruber ruber
phorb-a0a091u497 Phoenicopterus ruber ruber. Carboxymethylenebutenolidase Phoenicopterus ruber ruber
phymc-a0a2y9epy5 Physeter macrocephalus (Sperm whale) (Physeter catodon). carboxymethylenebutenolidase homolog Physeter macrocephalus
pig-a0a480hcw6 Sus scrofa (Pig). Carboxymethylenebutenolidase homolog Sus scrofa
podcr-a0a094ler5 Podiceps cristatus (Great crested grebe). Carboxymethylenebutenolidase Podiceps cristatus
poefo-a0a087x726 Poecilia formosa (Amazon molly) (Limia formosa)\; Poecilia mexicana. Carboxymethylenebutenolidase homolog (Pseudomonas)\; Poeciliopsis prolifica (blackstripe livebearer) Poecilia formosa
poere-a0a3p9pgz7 Poecilia reticulata (Guppy) (Acanthophacelus reticulatus). Carboxymethylenebutenolidase homolog (Pseudomonas) Poecilia reticulata
ponab-a0a2j8shi6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). CMBL isoform 2 Pongo abelii
ponpy-q5rbu3 Pongo pygmaeus (Orangutan) hypothetical protein dkfzp469h2233 Pongo pygmaeus
proco-a0a2k6fd38 Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli). Carboxymethylenebutenolidase homolog Propithecus coquereli
pygad-a0a093nub2 Pygoscelis adeliae (Adelie penguin). Carboxymethylenebutenolidase Pygoscelis adeliae
pygna-a0a3b4cjy3 Pygocentrus nattereri (Red-bellied piranha). Carboxymethylenebutenolidase homolog (Pseudomonas) Pygocentrus nattereri
rabit-g1sqa1 Oryctolagus cuniculus (Rabbit). Carboxymethylenebutenolidase homolog Oryctolagus cuniculus
ratno-CMBL Rattus norvegicus (Rat) ab2-225 (2310016a09rik protein) Rattus norvegicus
rhibe-a0a2k6jn19 Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)\; Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana). Carboxymethylenebutenolidase homolog Rhinopithecus bieti
sacko-a0a1l7h7f0 Saccoglossus kowalevskii (Acorn worm). Dienelactone hydrolase-like protein 154 Saccoglossus kowalevskii
sacko-a0a1l7h7f2 Saccoglossus kowalevskii (Acorn worm). Dienelactone hydrolase-like protein 278 Saccoglossus kowalevskii
saibb-a0a2k6slu5 Saimiri boliviensis boliviensis (Bolivian squirrel monkey). Carboxymethylenebutenolidase homolog Saimiri boliviensis boliviensis
salsa-a0a1s3qb19 Salmo salar (Atlantic salmon). carboxymethylenebutenolidase homolog Salmo salar
sclfo-a0a0p7y827 Scleropages formosus (Asian bonytongue) (Osteoglossum formosum). Carboxymethylenebutenolidase-like Scleropages formosus
scomx-a0a2u9cxw0 Scophthalmus maximus (Turbot) (Psetta maxima). Carboxymethylenebutenolidase-like isoform 2 Scophthalmus maximus
serdu-a0a3b4tai1 Seriola dumerili (Greater amberjack) (Caranx dumerili)\; Seriola lalandi dorsalis. Carboxymethylenebutenolidase homolog (Pseudomonas) Seriola dumerili
setit-a0a368qif6 Setaria italica (Foxtail millet) (Panicum italicum)\; Setaria viridis (Green bristlegrass) (Setaria italica subsp. viridis). DLH domain-containing protein Setaria italica
sheep-w5pxj8 Ovis aries (Sheep). Carboxymethylenebutenolidase homolog Ovis aries
soybn-i1kfz9 Glycine max (Soybean) (Glycine hispida)\; Glycine soja (Wild soybean). Carboxymethylenebutenolidase-like Glycine max
strca-a0a093h1v0 Struthio camelus australis. Carboxymethylenebutenolidase Struthio camelus australis
strca-a0a093h897 Struthio camelus australis. Carboxymethylenebutenolidase Struthio camelus australis
taeas-a0a0r3w800 Taenia asiatica (Asian tapeworm). DLH domain-containing protein Taenia asiatica
taegu-h0zb80 Taeniopygia guttata (Zebra finch) (Poephila guttata). DLH domain-containing protein Taeniopygia guttata
taegu-h0zb89 Taeniopygia guttata (Zebra finch) (Poephila guttata). DLH domain-containing protein Taeniopygia guttata
tarsy-a0a1u7v5h0 Tarsius syrichta (Philippine tarsier). carboxymethylenebutenolidase homolog Tarsius syrichta
tauer-a0a093epa2 Tauraco erythrolophus (Red-crested turaco). Carboxymethylenebutenolidase Tauraco erythrolophus
tetng-q4smy3 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 6 scaf14544, whole genome shotgun sequence Tetraodon nigroviridis
tingu-a0a099yy87 Tinamus guttatus (White-throated tinamou). Carboxymethylenebutenolidase Tinamus guttatus
tingu-a0a099z2x0 Tinamus guttatus (White-throated tinamou). Carboxymethylenebutenolidase Tinamus guttatus
trima-a0a2y9dsm3 Trichechus manatus latirostris (Florida manatee). carboxymethylenebutenolidase homolog Trichechus manatus latirostris
tupch-l9l5b1 Tupaia chinensis (Chinese tree shrew). Carboxymethylenebutenolidase like protein Tupaia chinensis
turtr-a0a2u4cmt5 Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus). carboxymethylenebutenolidase homolog Tursiops truncatus
tytal-a0a093et51 Tyto alba (Barn owl). Carboxymethylenebutenolidase Tyto alba
ursma-a0a452vbh6 Ursus maritimus (Polar bear) (Thalarctos maritimus)\; Ursus americanus (American black bear) (Euarctos americanus)\; Ursus arctos horribilis. Carboxymethylenebutenolidase homolog Ursus maritimus
vomur-a0a4x2lut0 Vombatus ursinus (Common wombat). DLH domain-containing protein Vombatus ursinus
vulvu-a0a3q7u6a5 Vulpes vulpes (Red fox). carboxymethylenebutenolidase homolog isoform X1 Vulpes vulpes
wheat-a0a3b5y329 Triticum aestivum (Wheat)\; Triticum turgidum subsp. durum (Durum wheat) (Triticum durum). DLH domain-containing protein Triticum aestivum
wheat-a0a3b5zwb6 Triticum aestivum (Wheat)\; Aegilops tauschii subsp. strangulata (Goatgrass)\; Aegilops tauschii (Tausch's goatgrass) (Aegilops squarrosa). Carboxymethylenebutenolidase Triticum aestivum
xenla-q5xh09 Xenopus laevis (African clawed frog)\; Hymenochirus curtipes (western dwarf clawed frog) loc495096 protein. Putative carboxymethylenebutenolidase Xenopus laevis
xentr-q6p7k0 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) hypothetical protein mgc76315 Xenopus tropicalis
xipma-a0a3b5q4l7 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). Carboxymethylenebutenolidase homolog (Pseudomonas) Xiphophorus maculatus

Gene_locus_frgt Name Species
9gobi-a0a3b4b4h1 Periophthalmus magnuspinnatus. Carboxymethylenebutenolidase homolog (Pseudomonas) Periophthalmus magnuspinnatus
9plat-a0a1i8h8j4 Macrostomum lignano. DLH domain-containing protein Macrostomum lignano
9saur-a0a452hm67 Gopherus agassizii (Agassiz's desert tortoise). DLH domain-containing protein Gopherus agassizii
acirt-a0a444tx55 Acipenser ruthenus (Sterlet sturgeon). Carboxymethylenebutenolidase-like Acipenser ruthenus
aegts-a0a452z6h8 Aegilops tauschii subsp. strangulata (Goatgrass). Uncharacterized protein Aegilops tauschii subsp. strangulata
anapp-a0a493tsa6 Anas platyrhynchos platyrhynchos (Northern mallard). DLH domain-containing protein Anas platyrhynchos platyrhynchos
calsu-a0a226nca5 Callipepla squamata (Scaled quail). Uncharacterized protein Callipepla squamata
cascn-a0a250xvg5 Castor canadensis (American beaver). Carboxymethylenebutenolidase Castor canadensis
cereh-a0a212c8i9 Cervus elaphus hippelaphus (European red deer). CMBL Cervus elaphus hippelaphus
chemy-m7bpm4 Chelonia mydas (Green sea-turtle) (Chelonia agassizi). Carboxymethylenebutenolidase like protein Chelonia mydas
colli-a0a2i0mwb0 Columba livia (Rock dove). Carboxymethylenebutenolidase homolog, transcript variant X1 Columba livia
colvi-a0a226nrv8 Colinus virginianus (Northern bobwhite) (Tetrao virginianus). DLH domain-containing protein Colinus virginianus
escro-a0a2f0b8a2 Eschrichtius robustus (California gray whale) (Eschrichtius gibbosus). Carboxymethylenebutenolidase Eschrichtius robustus
funhe-a0a3q2tlf7 Fundulus heteroclitus (Killifish) (Mummichog). Carboxymethylenebutenolidase homolog (Pseudomonas) Fundulus heteroclitus
hirru-a0a3m0krv4 Hirundo rustica rustica. DLH domain-containing protein Hirundo rustica rustica
hydta-a0a0r3wv70 Hydatigera taeniaeformis (Feline tapeworm) (Taenia taeniaeformis). Uncharacterized protein Hydatigera taeniaeformis taeniaeformis
loxaf-g3uei7 Loxodonta africana (African elephant). DLH domain-containing protein Loxodonta africana
micle-a0a2d4jij8 Micrurus lemniscatus lemniscatus. DLH domain-containing protein Micrurus lemniscatus lemniscatus
neobr-a0a3q4g0t6 Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi). Carboxymethylenebutenolidase homolog (Pseudomonas) Neolamprologus brichardi
neovi-u6dr55 Neovison vison (American mink) (Mustela vison). Carboxymethylenebutenolidase homolog Neovison vison
ophha-v8pbf0.1 Ophiophagus hannah (King cobra) (Naja hannah). Carboxymethylenebutenolidase-like protein Ophiophagus hannah
patfa-a0a1v4jwc0 Patagioenas fasciata monilis. Carboxymethylenebutenolidase-like protein Patagioenas fasciata monilis
pelsi-k7fm87 Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis). DLH domain-containing protein Pelodiscus sinensis
podcr-a0a094nma0 Podiceps cristatus (Great crested grebe). Carboxymethylenebutenolidase Podiceps cristatus
poptr-a0a3n7gsn1 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa). Uncharacterized protein Populus trichocarpa
pteal-l5kfg6 Pteropus alecto (Black flying fox). Carboxymethylenebutenolidase like protein Pteropus alecto
pygad-a0a093p0l7 Pygoscelis adeliae (Adelie penguin). Carboxymethylenebutenolidase Pygoscelis adeliae
sarha-g3veg2 Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). DLH domain-containing protein Sarcophilus harrisii
tauer-a0a093cqn0 Tauraco erythrolophus (Red-crested turaco). Carboxymethylenebutenolidase Tauraco erythrolophus
tripr-a0a2k3l4b8 Trifolium pratense (Red clover). Carboxymethylenebutenolidase-like protein Trifolium pratense
triua-m7yi02 Triticum urartu (Red wild einkorn) (Crithodium urartu). Uncharacterized protein Triticum urartu
tupch-l9ky23 Tupaia chinensis (Chinese tree shrew). Carboxymethylenebutenolidase like protein Tupaia chinensis

Substrate Chemical Nomenclature Proteins
CurDD 4,4'-((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene)diethyl disuccinate human-CES2    human-CES1    human-CMBL    human-BCHE
Olmesartan-medoxomil (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate human-CMBL

References (2)

Title : Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine - Ishizuka_2013_Drug.Metab.Dispos_41_1156
Author(s) : Ishizuka T , Rozehnal V , Fischer T , Kato A , Endo S , Yoshigae Y , Kurihara A , Izumi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1156 , 2013
Abstract :
PubMedSearch : Ishizuka_2013_Drug.Metab.Dispos_41_1156
PubMedID: 23471504
Gene_locus related to this paper: human-CMBL

Title : Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine - Ishizuka_2010_J.Biol.Chem_285_11892
Author(s) : Ishizuka T , Fujimori I , Kato M , Noji-Sakikawa C , Saito M , Yoshigae Y , Kubota K , Kurihara A , Izumi T , Ikeda T , Okazaki O
Ref : Journal of Biological Chemistry , 285 :11892 , 2010
Abstract :
PubMedSearch : Ishizuka_2010_J.Biol.Chem_285_11892
PubMedID: 20177059
Gene_locus related to this paper: human-CMBL