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3. 9-Amino-6-chloro-2-methoxyacridine

9-Amino-6-chloro-2-methoxyacridine

General

Type : Acridine,Derivative of Tacrine

Chemical_Nomenclature : 6-chloro-2-methoxyacridin-9-amine

Canonical SMILES : CC(=O)NC1=C(C2=CC3=CC=CC=C3C4=C2C5=C(C=CC=C51)C=C4)O

InChI : InChI=1S\/C22H15NO2\/c1-12(24)23-21-17-8-4-6-13-9-10-16-15-7-3-2-5-14(15)11-18(22(21)25)20(16)19(13)17\/h2-11,25H,1H3,(H,23,24)

InChIKey : CGVDLHRSVYTJKP-UHFFFAOYSA-N

Other name(s) : ACMA,G 185,6-Chloro-2-methoxy-9-acridinamine,NSC 15300

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MW : 258.70

Formula : C14H11ClN2O

CAS_number : 3548-09-2

PubChem : 190803

UniChem : CGVDLHRSVYTJKP-UHFFFAOYSA-N

Target

Families : 9-Amino-6-chloro-2-methoxyacridine ligand of proteins in family
Carboxylesterase Carb_B_Chordata

References (2)

1. Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

Title : Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors - Tsurkan_2013_Chem.Biol.Interact_203_226

Author(s) : Tsurkan LG , Hatfield MJ , Edwards CC , Hyatt JL , Potter PM

Ref : Chemico-Biological Interactions , 203 :226 , 2013

Abstract : Tsurkan_2013_Chem.Biol.Interact_203_226

ESTHER : Tsurkan_2013_Chem.Biol.Interact_203_226

PubMedSearch : Tsurkan_2013_Chem.Biol.Interact_203_226

PubMedID: 23123248

2. Mammalian carboxylesterases: from drug targets to protein therapeutics

Title : Mammalian carboxylesterases: from drug targets to protein therapeutics - Redinbo_2005_Drug.Discov.Today_10_313

Author(s) : Redinbo MR , Potter PM

Ref : Drug Discov Today , 10 :313 , 2005

Abstract : Redinbo_2005_Drug.Discov.Today_10_313

ESTHER : Redinbo_2005_Drug.Discov.Today_10_313

PubMedSearch : Redinbo_2005_Drug.Discov.Today_10_313

PubMedID: 15749280

Array
(
    [id] => 5814
    [inhibitor] => 9-Amino-6-chloro-2-methoxyacridine
    [type] => Array
        (
            [0] => Acridine
            [1] => Derivative of Tacrine
        )

    [other_name] => Array
        (
            [0] => ACMA
            [1] => G 185
            [2] => 6-Chloro-2-methoxy-9-acridinamine
            [3] => NSC 15300
        )

    [chemical_nomenclature] => 6-chloro-2-methoxyacridin-9-amine
    [formula] => C14H11ClN2O
    [cas_number] => 3548-09-2
    [mw] => 258.70
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Redinbo_2005_Drug.Discov.Today_10_313 || Tsurkan_2013_Chem.Biol.Interact_203_226
    [comment] => 
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 190803
    [family] => Carboxylesterase || Carb_B_Chordata
    [inchikey] => CGVDLHRSVYTJKP-UHFFFAOYSA-N
    [canonicalsmiles] => CC(=O)NC1=C(C2=CC3=CC=CC=C3C4=C2C5=C(C=CC=C51)C=C4)O
    [inchi] => InChI=1S\/C22H15NO2\/c1-12(24)23-21-17-8-4-6-13-9-10-16-15-7-3-2-5-14(15)11-18(22(21)25)20(16)19(13)17\/h2-11,25H,1H3,(H,23,24)
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)