DB07148
General
Type : Pyrrolidine
Chemical_Nomenclature : (6S)-1-chloro-3-[(4-fluorophenyl)methoxy]-6-(pyrrolidine-1-carbonyl)-6H-pyrrolo[1,2-a]pyrazin-4-one
Canonical SMILES : C1CCN(C1)C(=O)C2C=CC3=C(N=C(C(=O)N23)OCC4=CC=C(C=C4)F)Cl
InChI : InChI=1S\/C19H17ClFN3O3\/c20-16-14-7-8-15(18(25)23-9-1-2-10-23)24(14)19(26)17(22-16)27-11-12-3-5-13(21)6-4-12\/h3-8,15H,1-2,9-11H2\/t15-\/m0\/s1
InChIKey : HPAFVLDARQIHPU-HNNXBMFYSA-N
Other name(s) : (6S)-1-chloro-3-[(4-fluorophenyl)methoxy]-6-(pyrrolidine-1-carbonyl)-6H-pyrrolo[1,2-a]pyrazin-4-one,552,GSK552
MW : 389.81
Formula : C19H17ClFN3O3
CAS_number :
PubChem : 46937054
UniChem : HPAFVLDARQIHPU-HNNXBMFYSA-N
IUPHAR :
Wikipedia :
Target
Families : DB07148 ligand of proteins in family: S9N_PPCE_Peptidase_S9
Stucture : 3DDU Prolyl Oligopeptidase with GSK552
Protein : human-PREP
References (1)
| Title : Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP) - Haffner_2008_Bioorg.Med.Chem.Lett_18_4360 |
| Author(s) : Haffner CD , Diaz CJ , Miller AB , Reid RA , Madauss KP , Hassell A , Hanlon MH , Porter DJ , Becherer JD , Carter LH |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4360 , 2008 |
| Abstract : Haffner_2008_Bioorg.Med.Chem.Lett_18_4360 |
| ESTHER : Haffner_2008_Bioorg.Med.Chem.Lett_18_4360 |
| PubMedSearch : Haffner_2008_Bioorg.Med.Chem.Lett_18_4360 |
| PubMedID: 18606544 |
| Gene_locus related to this paper: human-PREPL |