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Inhibitor Report for: JZL195

Inhibits MGLL and also FAAH (not alpha/beta hydrolase) ABHD6 and CES1

Type: Piperazine, FAAH inhibitor, Multitarget, pNP, Phenoxyphenyl
Chemical_Nomenclature: (4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
Canonical SMILES: C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
InChI: InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
Other name(s): JZL 195 ; JZL-195 ; CHEMBL606201 ; 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
MW: 433.45
Formula: C24H23N3O5
CAS_number: 1210004-12-8
PubChem: 46232606
IUPHAR: 8606

Target families
JZL195 ligand of proteins in family: Monoglyceridelipase_lysophospholip, Carb_B_Chordata, ABHD6-Lip
No structure

Protein target

Search PubMed for references concerning: JZL195

7 more
    Title: Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Abeta, HSP-70, Neuroinflammation, and Oxidative Stress
    Bajaj S, Zameer S, Jain S, Yadav V, Vohora D
    Ref: ACS Chem Neurosci, :, 2022 : PubMed


    Title: Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model
    Adamson Barnes NS, Mitchell VA, Kazantzis NP, Vaughan CW
    Ref: British Journal of Pharmacology, 173:77, 2016 : PubMed


    Title: Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model
    Anderson WB, Gould MJ, Torres RD, Mitchell VA, Vaughan CW
    Ref: Neuropharmacology, 81:224, 2014 : PubMed