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PGN33

Balanced dual acting butyrylcholinesterase inhibitor and human cannabinoid receptor 2 ligand

General

Type : Multitarget,Cannabinoid-Receptor-ligand

Chemical_Nomenclature : N-[2-[3-[(4-methoxyphenyl)methoxy]indazol-1-yl]ethyl]-N-propan-2-ylpropan-2-amine

Canonical SMILES : CC(C)N(CCN1C2=CC=CC=C2C(=N1)OCC3=CC=C(C=C3)OC)C(C)C

InChI : InChI=1S\/C23H31N3O2\/c1-17(2)25(18(3)4)14-15-26-22-9-7-6-8-21(22)23(24-26)28-16-19-10-12-20(27-5)13-11-19\/h6-13,17-18H,14-16H2,1-5H3

InChIKey : CTXLHWVBEFYFSI-UHFFFAOYSA-N

Other name(s) : CHEMBL3116280,SCHEMBL6854432,BDBM50447030,Compound3,1-(2-Diisopropylaminoethyl)-3-(4-methoxybenzyloxy)indazole

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MW : 436.35 || 381.52

Formula : C23H31N3O2

CAS_number :

PubChem : 51357598

UniChem : CTXLHWVBEFYFSI-UHFFFAOYSA-N

Target

Families : PGN33 ligand of proteins in family
BCHE

Protein :
human-BCHE

References (2)

1. Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer's Disease

Title : Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer's Disease - Del Cerro_2018_CNS.Drugs_32_579

Author(s) : Del Cerro P , Alquezar C , Bartolome F , Gonzalez-Naranjo P , Perez C , Carro E , Paez JA , Campillo NE , Martin-Requero A

Ref : CNS Drugs , 32 :579 , 2018

Abstract : Del Cerro_2018_CNS.Drugs_32_579

ESTHER : Del Cerro_2018_CNS.Drugs_32_579

PubMedSearch : Del Cerro_2018_CNS.Drugs_32_579

PubMedID: 29736745

2. Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease

Title : Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease - Gonzalez-Naranjo_2014_Eur.J.Med.Chem_73_56

Author(s) : Gonzalez-Naranjo P , Perez-Macias N , Campillo NE , Perez C , Aran VJ , Giron R , Sanchez-Robles E , Martin MI , Gomez-Canas M , Garcia-Arencibia M , Fernandez-Ruiz J , Paez JA

Ref : Eur Journal of Medicinal Chemistry , 73 :56 , 2014

Abstract : Gonzalez-Naranjo_2014_Eur.J.Med.Chem_73_56

ESTHER : Gonzalez-Naranjo_2014_Eur.J.Med.Chem_73_56

PubMedSearch : Gonzalez-Naranjo_2014_Eur.J.Med.Chem_73_56

PubMedID: 24378710

Array
(
    [id] => 2631
    [inhibitor] => PGN33
    [type] => Array
        (
            [0] => Multitarget
            [1] => Cannabinoid-Receptor-ligand
        )

    [other_name] => Array
        (
            [0] => CHEMBL3116280
            [1] => SCHEMBL6854432
            [2] => BDBM50447030
            [3] => Compound3
            [4] => 1-(2-Diisopropylaminoethyl)-3-(4-methoxybenzyloxy)indazole
        )

    [chemical_nomenclature] => N-[2-[3-[(4-methoxyphenyl)methoxy]indazol-1-yl]ethyl]-N-propan-2-ylpropan-2-amine
    [formula] => C23H31N3O2
    [cas_number] => 
    [mw] => 436.35 || 381.52
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Gonzalez-Naranjo_2014_Eur.J.Med.Chem_73_56 || Del Cerro_2018_CNS.Drugs_32_579
    [comment] => Balanced dual acting butyrylcholinesterase inhibitor and human cannabinoid receptor 2 ligand
    [gene_locus] => human-BCHE
    [kin_inhibitor] => 
    [cid] => 51357598
    [family] => BCHE
    [inchikey] => CTXLHWVBEFYFSI-UHFFFAOYSA-N
    [canonicalsmiles] => CC(C)N(CCN1C2=CC=CC=C2C(=N1)OCC3=CC=C(C=C3)OC)C(C)C
    [inchi] => InChI=1S\/C23H31N3O2\/c1-17(2)25(18(3)4)14-15-26-22-9-7-6-8-21(22)23(24-26)28-16-19-10-12-20(27-5)13-11-19\/h6-13,17-18H,14-16H2,1-5H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)