Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Subunit assembly dimerization deficient mutant are secreted in medium efficiently and undergo terminal glycosylation Kerem_1993_J.Biol.Chem_268_180 Kronman_1995_5th.ChE.Meeting.Madras__293 Velan_1994_J.Biol.Chem_269_22719 Velan_1995_5th.ChE.Meeting.Madras__269
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Subunit assembly
Torpedo_number : 572
Kinetic Parameter : Acetylthiocholine_C580A_human-ACHE
News : No news
Comment :
p.C580A Cys580Ala (p.C611A Cys611Ala in primary sequence with 31 amino-acids signal peptide) Subunit assembly\;dimerization deficient mutant are secreted in medium efficiently and undergo terminal glycosylation
| Title : Signal-Mediated Cellular Retention and Subunit Assembly of Human Acetylcholinesterase - |
| Author(s) : Kronman C , Flashner Y , Shafferman A , Velan B |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :293 , 1995 |
| PubMedID: |
| Title : Post-Translation Processing of Acetylcholinesterase - |
| Author(s) : Velan B , Kronman C , Ordentlich A , Flashner Y , Ber R |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :269 , 1995 |
| PubMedID: |
| Title : Reversal of signal-mediated cellular retention by subunit assembly of human acetylcholinesterase - Velan_1994_J.Biol.Chem_269_22719 |
| Author(s) : Velan B , Kronman C , Flashner Y , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :22719 , 1994 |
| Abstract : |
| PubMedSearch : Velan_1994_J.Biol.Chem_269_22719 |
| PubMedID: 8077224 |
| Title : Interrelations between assembly and secretion of recombinant human acetylcholinesterase - Kerem_1993_J.Biol.Chem_268_180 |
| Author(s) : Kerem A , Kronman C , Bar-Nun S , Shafferman A , Velan B |
| Ref : Journal of Biological Chemistry , 268 :180 , 1993 |
| Abstract : |
| PubMedSearch : Kerem_1993_J.Biol.Chem_268_180 |
| PubMedID: 8416926 |
| Title : The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant - Velan_1991_J.Biol.Chem_266_23977 |
| Author(s) : Velan B , Grosfeld H , Kronman C , Leitner M , Gozes Y , Lazar A , Flashner Y , Marcus D , Cohen S , Shafferman A |
| Ref : Journal of Biological Chemistry , 266 :23977 , 1991 |
| Abstract : |
| PubMedSearch : Velan_1991_J.Biol.Chem_266_23977 |
| PubMedID: 1748670 |