D349N_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Electrostatic Electrostatic attraction hypothesisminor effect on catalysis Shafferman_1994_EMBO.J_13_3448

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Electrostatic

Torpedo_number : 342

Kinetic Parameter : Acetylthiocholine_D349N_human-ACHE, 3,3-dimethylbutylthioacetate_D349N_human-ACHE, Edrophonium_D349N_human-ACHE

News : No news

Comment :
D349N p.Asp349Asn (D380N p.Asp380Asn in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesisminor effect on catalysis

References (3)

Title : Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase - Shafferman_1994_EMBO.J_13_3448
Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B
Ref : EMBO Journal , 13 :3448 , 1994
PubMedID: 8062821

Title : Acetylcholinesterase Catalysis - Protein Engineering Studies -
Author(s) : Shafferman A , Velan B
Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :165 , 1992
PubMedID:

Title : Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding - Shafferman_1992_J.Biol.Chem_267_17640
Author(s) : Shafferman A , Kronman C , Flashner Y , Leitner M , Grosfeld H , Ordentlich A , Gozes Y , Cohen S , Ariel N , Barak D , Harel M , Silman I , Sussman JL , Velan B
Ref : Journal of Biological Chemistry , 267 :17640 , 1992
PubMedID: 1517212