D54G_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : PROSS algorithm Expression in E Coli Brazzolotto_2017_Molecules_22_

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure : 6EMI

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Expression in E Coli || PROSS algorithm

Torpedo_number : 56

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.D54G Asp54Gly (p.D82G Asp82Gly in primary sequence with 28 amino-acids signal peptide) mutation designed by -Protein Repair One Stop Shop- process for the production of active human butyrylcholinesterase in a prokaryotic system. The mutation gives Gly as in ACHE (Torpedo, human, mouse, Bungar)

References (1)

Title : Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development - Brazzolotto_2017_Molecules_22_
Author(s) : Brazzolotto X , Igert A , Guillon V , Santoni G , Nachon F
Ref : Molecules , 22 : , 2017
PubMedID: 29077024
Gene_locus related to this paper: human-BCHE